BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 3 Record - 1 of 52 [TOP]

Compound ID	1207
Compound Structure
Plant Source	Aristolochia cauliflora Ule Common Name:
Source Family	Aristolochiaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Ethambutol (2 µg/ml) and Ethambutol (7.5 µg/ml)
Inhibition [%]	81 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 2 of 52 [TOP]

Compound ID

2864

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35837) (Ethambutol resistant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Eupomatenoid 7

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 L of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

C1c(cc(c2c1c(c(o2)c1cc(c(cc1)O)OC)C)OC)/C=C/C

XLogP

4.461

PSA

51.830

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) León-Díaz R, Meckes M, Said-Fernández S, Molina-Salinas GM, Vargas-Villarreal J, Torres J, Luna-Herrera J, Jiménez-Arellanes A.Antimycobacterial neolignans isolated from Aristolochia taliscana.Mem Inst Oswaldo Cruz. 2010 Feb;105(1):45-51

Curator

Vikramjitmandal

Record - 3 of 52 [TOP]

Compound ID

2865

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27 294)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 L of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 4 of 52 [TOP]

Compound ID

2866

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35822) (Isoniazid resistant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 L of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 5 of 52 [TOP]

Compound ID

2867

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35838) (Rifampin resistant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 L of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 6 of 52 [TOP]

Compound ID

2868

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35820) (Streptomycin resistant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 L of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 7 of 52 [TOP]

Compound ID

2869

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35837) (Ethambutol resistant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 L of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 8 of 52 [TOP]

Compound ID

2870

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (Clinical isolate MMDO)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 L of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 9 of 52 [TOP]

Compound ID

2871

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY650)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 10 of 52 [TOP]

Compound ID

2872

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY663)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 11 of 52 [TOP]

Compound ID

2873

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY675)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 12 of 52 [TOP]

Compound ID

2874

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY282)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 13 of 52 [TOP]

Compound ID

2875

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (Clinical isolate HG8)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 14 of 52 [TOP]

Compound ID

2876

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (Clinical isolate SIN3)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 15 of 52 [TOP]

Compound ID

2877

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY234)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 16 of 52 [TOP]

Compound ID

2878

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY112)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 17 of 52 [TOP]

Compound ID

2879

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY559)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 18 of 52 [TOP]

Compound ID

2880

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (Clinical isolate SIN4)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 19 of 52 [TOP]

Compound ID

2881

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY172)

Assay / Test Done

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Licarin B

PubChem ID

5384942

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzofuranoid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C([C@H](c2c1c(OC)cc(c2)/C=C/C)C)c1cc2OCOc2cc1

XLogP

4.809

PSA

36.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 20 of 52 [TOP]

Compound ID

2883

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27 294)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Eupomatenoid 7

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

C1c(cc(c2c1c(c(o2)c1cc(c(cc1)O)OC)C)OC)/C=C/C

XLogP

4.461

PSA

51.830

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 21 of 52 [TOP]

Compound ID

2884

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35822) (Isoniazid resistant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Eupomatenoid 7

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

C1c(cc(c2c1c(c(o2)c1cc(c(cc1)O)OC)C)OC)/C=C/C

XLogP

4.461

PSA

51.830

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 22 of 52 [TOP]

Compound ID

2885

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35838) (Rifampin resistant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Eupomatenoid 7

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

C1c(cc(c2c1c(c(o2)c1cc(c(cc1)O)OC)C)OC)/C=C/C

XLogP

4.461

PSA

51.830

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 23 of 52 [TOP]

Compound ID

2886

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35820) (Streptomycin resistant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Eupomatenoid 7

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

C1c(cc(c2c1c(c(o2)c1cc(c(cc1)O)OC)C)OC)/C=C/C

XLogP

4.461

PSA

51.830

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 24 of 52 [TOP]

Compound ID

2887

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (Clinical isolate MMDO)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Eupomatenoid 7

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

C1c(cc(c2c1c(c(o2)c1cc(c(cc1)O)OC)C)OC)/C=C/C

XLogP

4.461

PSA

51.830

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 25 of 52 [TOP]

Compound ID

2888

Compound Structure

Plant Source

Aristolochia taliscana Hook. Common Name:Dutchman's Pipes

Source Family

Aristolochiaceae

Origin

Mexico

Plant Part Used

Root

Extract

N - hexane

Target Bacteria

Mycobacterium tuberculosis (clinical isolate MTY650)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Streptomycin (0.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.1 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Eupomatenoid 7

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

20209328

Extract Preparation

Powdered air - dried roots (1.5 kg) were macerated (3 × 48 h) with 12 l of n - Hexane. The extract was filtered and evaporated in vacuo to yield 33 g of the crude extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Furanoid, Alkene, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

J774A.1 murine macrophage cell line (ATCC HB - 197) using the trypan blue exclusion test

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

C1c(cc(c2c1c(c(o2)c1cc(c(cc1)O)OC)C)OC)/C=C/C

XLogP

4.461

PSA

51.830

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

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