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                  Page - 1 of 1                  Record - 1 of 11   [TOP]
Compound ID1221
Compound Structure
Plant SourceAsclepias fruticosa L. (and Asclepias physocarpa (E. Mey.) Schltr.)     Common Name:African Milkweed
Source FamilyAsclepiadaceae
OriginAfrica
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneTetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)Rifampin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (2.00 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationUsed for diarrhoea and stomach pain, facilitate child-birth, asthma, diabetes, tuberculosis, headache and emetic to strengthen the body
PubMed ID [Source Literature]20447452
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7

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                  Record - 2 of 11   [TOP]
Compound ID1222
Compound Structure
Plant SourceAsclepias fruticosa L. (and Asclepias physocarpa (E. Mey.) Schltr.)     Common Name:African Milkweed
Source FamilyAsclepiadaceae
OriginAfrica
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium tuberculosis 2 (Clinical isolates resistant to Streptomycin, Rifampin, Ethambutol, Isoniazid)
Assay / Test DoneTetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)Rifampin (100 µg/ml), Isoniazid (4.6 µg/ml), Ethambutol (12 µg/ml), Streptomycin (120 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationUsed for diarrhoea and stomach pain, facilitate child-birth, asthma, diabetes, tuberculosis, headache and emetic to strengthen the body
PubMed ID [Source Literature]20447452
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7

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                  Record - 3 of 11   [TOP]
Compound ID1340
Compound Structure
Plant SourceCalotropis gigantea (L.) R. Br. ex Ait.     Common Name:Madar (white-flowered), Giant Milk-weed (English), Alarka, Raajaarka, Shvetaarka (Sanskrit)
Source FamilyAsclepiadaceae
OriginIndia
Plant Part UsedMother tinture
ExtractEthanol (95 %)
Target BacteriaMycobacterium tuberculosis H37Rv (human)
Assay / Test DoneTube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationLeprosy, asthma, expectorant, cough, asthma, leprosy
PubMed ID [Source Literature]2118130
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

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                  Record - 4 of 11   [TOP]
Compound ID2022
Compound Structure
Plant SourceLeptadenia reticulata Wt.and Arn. syn. Asclepias tuberosa Roxb.     Common Name:Jivanti, Jivaniya, Jivapushpa (Sanskrit)
Source FamilyAsclepiadaceae
OriginIndia
Plant Part UsedMother tinture
ExtractEthanol
Target BacteriaMycobacterium tuberculosis H37Rv (human)
Assay / Test DoneTube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)1:40 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis, asthma, cough, random screening
PubMed ID [Source Literature]2118130
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Grange, J.M., Davey, R.W., 1990. Detection of antituberculous activity in plant extracts. Journal of Applied Bacteriology 68, 587–591

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                  Record - 5 of 11   [TOP]
Compound ID2023
Compound Structure
Plant SourceLeptadenia reticulata Wt.and Arn. syn. Asclepias tuberosa Roxb.     Common Name:Jivanti, Jivaniya, Jivapushpa (Sanskrit)
Source FamilyAsclepiadaceae
OriginIndia
Plant Part UsedLeaf
ExtractWater
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneBroth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)1:160 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis, asthma, cough, random screening
PubMed ID [Source Literature]17276637
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34

2) Sharma, P.K., Dhyani, S.K., Shanker,V., 1979. Some useful and medicinal plants of the district Dehradun and Siwalik. Journal of Science Research in Plant Medicine 1, 17–43.

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                  Record - 6 of 11   [TOP]
Compound ID2024
Compound Structure
Plant SourceLeptadenia reticulata Wt.and Arn. syn. Asclepias tuberosa Roxb.     Common Name:Jivanti, Jivaniya, Jivapushpa (Sanskrit)
Source FamilyAsclepiadaceae
OriginIndia
Plant Part UsedRoot
ExtractWater
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneBroth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis, asthma, cough, random screening
PubMed ID [Source Literature]17276637
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34

2) Sharma, P.K., Dhyani, S.K., Shanker,V., 1979. Some useful and medicinal plants of the district Dehradun and Siwalik. Journal of Science Research in Plant Medicine 1, 17–43.

Curator

                  Record - 7 of 11   [TOP]
Compound ID2025
Compound Structure
Plant SourceLeptadenia reticulata Wt.and Arn. syn. Asclepias tuberosa Roxb.     Common Name:Jivanti, Jivaniya, Jivapushpa (Sanskrit)
Source FamilyAsclepiadaceae
OriginIndia
Plant Part UsedWhole plant
ExtractCyclohexane
Target BacteriaMycobacterium smegmatis
Assay / Test DoneAgar - Well Diffusion Assay
Positive Control Used (conc.)Streptomycin sulphate (1 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)2 mm, 20 mm (control)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis, asthma, cough, random screening
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) James D. Mcchesney, Robert P. Adams.Co-evaluation of plant extracts as petrochemical substitutes and for biologically active compounds.Economic Botany. 12/1984, 39(1):74-86

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                  Record - 8 of 11   [TOP]
Compound ID2026
Compound Structure
Plant SourceLeptadenia reticulata Wt.and Arn. syn. Asclepias tuberosa Roxb.     Common Name:Jivanti, Jivaniya, Jivapushpa (Sanskrit)
Source FamilyAsclepiadaceae
OriginIndia
Plant Part UsedWhole plant
ExtractWater
Target BacteriaMycobacterium smegmatis
Assay / Test DoneAgar - Well Diffusion Assay
Positive Control Used (conc.)Streptomycin sulphate (1 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)1 mm, 20 mm (control)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis, asthma, cough, random screening
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) James D. Mcchesney, Robert P. Adams.Co-evaluation of plant extracts as petrochemical substitutes and for biologically active compounds.Economic Botany. 12/1984, 39(1):74-86

Curator

                  Record - 9 of 11   [TOP]
Compound ID4038
Compound Structure
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Plant SourceBlepharodon nitidum     Common Name:
Source FamilyAsclepiadaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis (H37Rv and MDR strain)
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedEJMC68
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Alicyclic, Pentacyclic, Terpene, Triterpene, Cycloartane, Peroxy, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight458.376
Molecular FormulaC30H50O3
SMILESC=C(C)C(OO)CC[C@@H](C)[C@H]1CC[C@@]2(C)C3CCC4C(C)(C)[C@@H](O)CC[C@@]54[C@]3(C5)CC[C@]12C
XLogP9.986
PSA49.690
H-bond Donor2
H-bond Acceptor3
No. of Rotatable Bond Count6
No. of Rings5
No. of N0
No. of O3
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

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                  Record - 10 of 11   [TOP]
Compound ID4134
Compound Structure
DOWNLOAD:
Plant SourceBlepharodon nitidum     Common Name:
Source FamilyAsclepiadaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedEJMC69
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Alicyclic, Pentacyclic, Terpene, Triterpene, Cycloartane, Peroxy, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight458.376
Molecular FormulaC30H50O3
SMILESCC(C)(OO)/C=C/C[C@@H](C)[C@H]1CC[C@@]2(C)C3CCC4C(C)(C)[C@@H](O)CC[C@@]54[C@]3(C5)CC[C@]12C
XLogP10.306
PSA49.690
H-bond Donor2
H-bond Acceptor3
No. of Rotatable Bond Count5
No. of Rings5
No. of N0
No. of O3
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

                  Record - 11 of 11   [TOP]
Compound ID4135
Compound Structure
DOWNLOAD:
Plant SourceBlepharodon nitidum     Common Name:
Source FamilyAsclepiadaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis (MDR strain)
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedEJMC69
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Alicyclic, Pentacyclic, Terpene, Triterpene, Cycloartane, Peroxy, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight458.376
Molecular FormulaC30H50O3
SMILESCC(C)(OO)/C=C/C[C@@H](C)[C@H]1CC[C@@]2(C)C3CCC4C(C)(C)[C@@H](O)CC[C@@]54[C@]3(C5)CC[C@]12C
XLogP10.306
PSA49.690
H-bond Donor2
H-bond Acceptor3
No. of Rotatable Bond Count5
No. of Rings5
No. of N0
No. of O3
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator


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