BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 8 [TOP]

Compound ID	2006
Compound Structure
Plant Source	Laurelia novae - zelandiae Common Name:Pukatea
Source Family	Atherospermataceae
Origin	New Zealand
Plant Part Used	Inner Bark
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	96 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]	90 %
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sores, ulcers, toothache and tuberculosis
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 2 of 8 [TOP]

Compound ID	2007
Compound Structure
Plant Source	Laurelia novae - zelandiae Common Name:Pukatea
Source Family	Atherospermataceae
Origin	New Zealand
Plant Part Used	Inner Bark
Extract	Methanol
Target Bacteria	Mycobacterium bovis
Assay / Test Done	97 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]	90 %
Activity [MIC] µg/ml	2500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sores, ulcers, toothache and tuberculosis
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 3 of 8 [TOP]

Compound ID	2008
Compound Structure
Plant Source	Laurelia novae - zelandiae Common Name:Pukatea
Source Family	Atherospermataceae
Origin	New Zealand
Plant Part Used	Inner Bark
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	98 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]	90 %
Activity [MIC] µg/ml	3750 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sores, ulcers, toothache and tuberculosis
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 4 of 8 [TOP]

Compound ID	2009
Compound Structure
Plant Source	Laurelia novae - zelandiae Common Name:Pukatea
Source Family	Atherospermataceae
Origin	New Zealand
Plant Part Used	Bark
Extract	Water
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	96 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]	90 %
Activity [MIC] µg/ml	40 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sores, ulcers, toothache and tuberculosis
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 5 of 8 [TOP]

Compound ID	2010
Compound Structure
Plant Source	Laurelia novae - zelandiae Common Name:Pukatea
Source Family	Atherospermataceae
Origin	New Zealand
Plant Part Used	Bark
Extract	Water
Target Bacteria	Mycobacterium bovis
Assay / Test Done	97 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]	90 %
Activity [MIC] µg/ml	1500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sores, ulcers, toothache and tuberculosis
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 6 of 8 [TOP]

Compound ID	2011
Compound Structure
Plant Source	Laurelia novae - zelandiae Common Name:Pukatea
Source Family	Atherospermataceae
Origin	New Zealand
Plant Part Used	Bark
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	98 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]	90 %
Activity [MIC] µg/ml	4160 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sores, ulcers, toothache and tuberculosis
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 7 of 8 [TOP]

Compound ID	2918
Compound Structure	NR
Plant Source	Laurelia novae - zelandiae Common Name:Pukatea
Source Family	Atherospermataceae
Origin	New Zealand
Plant Part Used	Bark
Extract	Water
Target Bacteria	Mycobacterium smegmatis mc² 155
Assay / Test Done
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]	>= 90 % (2 mg/ml)
Activity [MIC] µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Treat sores, skin conditions, venereal disease
PubMed ID [Source Literature]	20537175
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator	Farzana-shamsudeen-shamsudeen

Record - 8 of 8 [TOP]

Compound ID	2922
Compound Structure	NR
Plant Source	Laurelia novae - zelandiae Common Name:Pukatea
Source Family	Atherospermataceae
Origin	New Zealand
Plant Part Used	Cambium
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis mc² 155
Assay / Test Done
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]	>= 90 % (2 mg/ml)
Activity [MIC] µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	20537175
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator	Vikramjitmandal

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