BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 13 [TOP]

Compound ID	1175
Compound Structure
Plant Source	Anaemopegma chrysoleucum (H.B.K.) Sandwith Common Name:
Source Family	Bignoniaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 2 of 13 [TOP]

Compound ID	1176
Compound Structure
Plant Source	Anaemopegma paraense Bureau & Schumann Common Name:
Source Family	Bignoniaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 3 of 13 [TOP]

Compound ID	1208
Compound Structure
Plant Source	Arrabidaea cinnamomea (A. DC.) Sandw Common Name:
Source Family	Bignoniaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 4 of 13 [TOP]

Compound ID	1339
Compound Structure
Plant Source	Callichlamys latifolia (Richard) Schumann Common Name:
Source Family	Bignoniaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 5 of 13 [TOP]

Compound ID	1551
Compound Structure
Plant Source	Crescentia amazonica Ducke Common Name:
Source Family	Bignoniaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 6 of 13 [TOP]

Compound ID	1581
Compound Structure
Plant Source	Cydista lilacina A. Gentry Common Name:
Source Family	Bignoniaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 7 of 13 [TOP]

Compound ID	2090
Compound Structure
Plant Source	Lundia corymbifera (Vahl) Sandw Common Name:
Source Family	Bignoniaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 8 of 13 [TOP]

Compound ID	2144
Compound Structure
Plant Source	Martinella obovata (H.B.K.) Bureau & Schum Common Name:
Source Family	Bignoniaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 9 of 13 [TOP]

Compound ID	2644
Compound Structure
Plant Source	Stereospermum kunthianum Cham. Common Name:Pink Jacaranda
Source Family	Bignoniaceae
Origin	Nigeria
Plant Part Used	Stem bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 2500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cancer, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) Mann A, Gbate M, Nda-Umar A. Medicinal and Economic Plants of Nupeland. Bida, Niger State, Nigeria: Jube-Evans Books and Publications; 2003. p. 276 3) http://www.zimbabweflora.co.zw/speciesdata/species.php?species_id=152430
Curator

Record - 10 of 13 [TOP]

Compound ID	2687
Compound Structure
Plant Source	Tanacium nocternum (Barb. Rodr.) Bureau & Schum Common Name:
Source Family	Bignoniaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) radiometric assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 11 of 13 [TOP]

Compound ID

4034

Compound Structure

Plant Source

Radermachera boniana Common Name:

Source Family

Bignoniaceae

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

16.8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Bonianic acid A

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Pentacyclic, Terpene, Triterpene, Prenylated, O-Acetyl, Acid

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

484.355

Molecular Formula

C₃₁H₄₈O₄

SMILES

[C@H]12[C@](C)(C(=O)O)[C@@H](OC(=O)C)CC[C@@]31[C@@]1(C3)C([C@@H]3CC[C@H]([C@@H](CCC=C(C)C)C)[C@@]3(C)CC1)CC2

XLogP

10.616

PSA

63.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

Record - 12 of 13 [TOP]

Compound ID

4035

Compound Structure

Plant Source

Radermachera boniana Common Name:

Source Family

Bignoniaceae

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Bonianic acid B

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Pentacyclic, Terpene, Triterpene, O-Acetyl, Acid

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

500.350

Molecular Formula

C₃₁H₄₈O₅

SMILES

[C@H]12[C@](C)(C(=O)O)[C@@H](OC(=O)C)CC[C@@]31[C@@]1(C3)C([C@@H]3CC[C@H]([C@@H](CCC(=O)C(C)C)C)[C@@]3(C)CC1)CC2

XLogP

8.764

PSA

80.670

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 13 of 13 [TOP]

Compound ID

4039

Compound Structure

Plant Source

Radermachera boniana Common Name:

Source Family

Bignoniaceae

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

39.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

β-Sitostenone

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Tetracyclic, Steroid, Ketone

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

410.355

Molecular Formula

C₂₉H₄₆O

SMILES

C[C@]12C(=CC(=O)CC2)CCC2[C@@H]3CC[C@H]([C@H](C)CC[C@H](C(C)C)CC)[C@@]3(C)CC=C12

XLogP

11.136

PSA

17.070

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

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