BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 12 [TOP]

Compound ID	1245
Compound Structure
Plant Source	Bauhinia vahlii Wt. & Arn. Common Name:
Source Family	Caesalpiniaceae
Origin	India
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Chloramphenicol
Inhibition [%]
Activity [MIC] µg/ml	3000000 µg/ml of dried plant material
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Dysentery, stomach ache, tonic, aphrodisiac, cuts, wounds
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 2 of 12 [TOP]

Compound ID	1246
Compound Structure
Plant Source	Bauhinia variegata L. Common Name:Mountain Ebony, Buddhist Bauhinia (English), Kaanchanaara, Kanchanak (Sanskrit)
Source Family	Caesalpiniaceae
Origin	India
Plant Part Used	Seed
Extract	Protein fraction
Target Bacteria	Mycobacterium rhodochrous
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, tuberculous glands, bronchitis, consumption, cough, asthma
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 3 of 12 [TOP]

Compound ID	1328
Compound Structure
Plant Source	Caesalpinia digyna Rottl. Common Name:Teri Pods (English), Vaakeri (Sanskrit)
Source Family	Caesalpiniaceae
Origin	India
Plant Part Used	Root
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Phthisis, glandular, intestinal and bone tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Patel, M.R., R.A. Bellare and C.V. Deliwala.Antitubercular action of Caesalpinia digyna Rottl. roots.IJEB 4, 4, 214-215 2) Anon., 1967. Antibacterial action of Vakeri root. Indian Journal of Pharmacy 29, 103–104.
Curator

Record - 4 of 12 [TOP]

Compound ID	1329
Compound Structure
Plant Source	Caesalpinia digyna Rottl. Common Name:Teri Pods (English), Vaakeri (Sanskrit)
Source Family	Caesalpiniaceae
Origin	India
Plant Part Used	Root
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Phthisis, glandular, intestinal and bone tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Patel, M.R., R.A. Bellare and C.V. Deliwala.Antitubercular action of Caesalpinia digyna Rottl. roots.IJEB 4, 4, 214-215 2) Anon., 1967. Antibacterial action of Vakeri root. Indian Journal of Pharmacy 29, 103–104.
Curator

Record - 5 of 12 [TOP]

Compound ID	1330
Compound Structure
Plant Source	Caesalpinia digyna Rottl. Common Name:Teri Pods (English), Vaakeri (Sanskrit)
Source Family	Caesalpiniaceae
Origin	India
Plant Part Used	Root
Extract	Water:Ethanol (80:20)
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)	1:80 dilution (It was 7 times more active than Ethanol extract and 5 times more active than aqueous extract)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Phthisis, glandular, intestinal and bone tuberculosis
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Patel, M.R., R.A. Bellare and C.V. Deliwala.Antitubercular action of Caesalpinia digyna Rottl. roots.IJEB 4, 4, 214-215 3) Anon., 1967. Antibacterial action of Vakeri root. Indian Journal of Pharmacy 29, 103–104.
Curator

Record - 6 of 12 [TOP]

Compound ID

1335

Compound Structure

Plant Source

Caesalpinia pulcherrima (L.) Sw. Common Name:Barbados Pride (English), Padangam, Ratnagandhi, Krishnachuudaa (Sanskrit)

Source Family

Caesalpiniaceae

Origin

India

Plant Part Used

Root

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 – 0.090 µg/ml) and Kanamycin sulphate (2 – 5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

6β - Cinnamoyl - 7β - Hydroxyvouacapen - 5α - Ol

PubChem ID

6479669

Ethnomedicinal Information

Tuberculosis, bronchitis, asthma

PubMed ID [Source Literature]

14531033

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tetracyclic, Terpene, Diterpene, Furanoid, Cinnamoyl, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against KB, BC, NCI - H187 cell lines

Molecular Weight

464.256

Molecular Formula

C₂₉H₃₆O₅

SMILES

O[C@]12[C@@]([C@@H]3[C@@H]([C@@H](O)[C@H]1OC(=O)/C=C/c1ccccc1)[C@H](c1c(occ1)C3)C)(CCCC2(C)C)C

XLogP

7.503

PSA

79.900

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Promsawan N, Kittakoop P, Boonphong S, Nongkunsarn P.Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima.Planta Med. 2003 Aug;69(8):776-7

2) Chopra, R.N., Nayar, S.L., Chopra, R.C., 1956. Glossary of Indian Medicinal Plants. Council of Scientific and Industrial Research, New Delhi, India

Curator

Record - 7 of 12 [TOP]

Compound ID	1597
Compound Structure
Plant Source	Delonix regia (Bojer ex Hook.) Raf. Common Name:Flamboyant Flame Tree, Gold Mohur (English), Gulmohar (Sanskrit)
Source Family	Caesalpiniaceae
Origin	India, Puerto Rico
Plant Part Used	Stem
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Radiorespirometric Bioassay
Positive Control Used (conc.)	Rifampin (1 µg/ml)
Inhibition [%]	60 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Spider bite, folklore medicine of Puerto Rico
PubMed ID [Source Literature]	11746852
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42 2) http://www.tropilab.com/delonix-reg.html
Curator

Record - 8 of 12 [TOP]

Compound ID	1598
Compound Structure
Plant Source	Delonix regia (Bojer ex Hook.) Raf. Common Name:Flamboyant Flame Tree, Gold Mohur (English), Gulmohar (Sanskrit)
Source Family	Caesalpiniaceae
Origin	India, Puerto Rico
Plant Part Used	Leaf
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Middlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)	Rifampin (1 µg/ml)
Inhibition [%]	38 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Spider bite, folklore medicine of Puerto Rico
PubMed ID [Source Literature]	11746852
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42 2) http://www.tropilab.com/delonix-reg.html
Curator

Record - 9 of 12 [TOP]

Compound ID	1600
Compound Structure
Plant Source	Detarium microcarpium Common Name:
Source Family	Caesalpiniaceae
Origin	Nigeria
Plant Part Used
Extract
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Ibrahim, K., Oyewale, A.O., Amupitan, J.O., and Okogun, J.I., 2009, Antimycobacterial activity of some me-dicinal plants in Niger State, Nigeria. Afri. J. Infect. Dis., 3(2), 44-48
Curator

Record - 10 of 12 [TOP]

Compound ID	2573
Compound Structure
Plant Source	Schotia brachypetala Sond Common Name:Weeping Boer Bean
Source Family	Caesalpiniaceae
Origin	Africa
Plant Part Used	Bark
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (2.00 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used to treat dysentery and diarrhoea, tuberculosis
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 11 of 12 [TOP]

Compound ID	2574
Compound Structure
Plant Source	Schotia brachypetala Sond Common Name:Weeping Boer Bean
Source Family	Caesalpiniaceae
Origin	Africa
Plant Part Used	Bark
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis 2 (Clinical isolates resistant to Streptomycin, Rifampin, Ethambutol, Isoniazid)
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (100 µg/ml), Isoniazid (4.6 µg/ml), Ethambutol (12 µg/ml), Streptomycin (120 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used to treat dysentery and diarrhoea, tuberculosis
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 12 of 12 [TOP]

Compound ID

3225

Compound Structure

Plant Source

Ceasalpinia pulcherrima (L.) Sw. Common Name:Barbados Pride (English), Padangam, Ratnagandhi, Krishnachuudaa (Sanskrit)

Source Family

Caesalpiniaceae

Origin

India

Plant Part Used

Root

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 - 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

6β - Benzoyl - 7β - Hydroxyvouacapen - 5 α - Ol

PubChem ID

3009285

Ethnomedicinal Information

Bronchitis, asthma

PubMed ID [Source Literature]

14531033

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Tetracyclic, Terpene, Diterpene, Furanoid, Benzoyl, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Against KB, BC, NCI - H187 cell lines

Molecular Weight

438.241

Molecular Formula

C₂₇H₃₄O₅

SMILES

O[C@]12[C@@]([C@@H]3[C@@H]([C@@H](O)[C@H]1OC(=O)c1ccccc1)[C@H](c1c(occ1)C3)C)(CCCC2(C)C)C

XLogP

6.265

PSA

79.900

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Farzana-shamsudeen, vikramjitmandal

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