BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 10 [TOP]

Compound ID	2800
Compound Structure
Plant Source	Warbugia salutaris (Bertol. f.) Chiov Common Name:Pepper - Bark Tree
Source Family	Canellaceae
Origin	Africa
Plant Part Used	Leaf
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (2.00 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Colds, sinuses, influenza and other chest complaints, antiparasitic powder applied to sores, fever, coughs, respiratory ailments
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7 2) http://www.plantzAfrica.com/plantwxyz/warburg.htm
Curator

Record - 2 of 10 [TOP]

Compound ID	2801
Compound Structure
Plant Source	Warbugia salutaris (Bertol. f.) Chiov Common Name:Pepper - Bark Tree
Source Family	Canellaceae
Origin	Africa
Plant Part Used	Leaf
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis 2 (Clinical isolates resistant to Streptomycin, Rifampin, Ethambutol, Isoniazid)
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (100 µg/ml), Isoniazid (4.6 µg/ml), Ethambutol (12 µg/ml), Streptomycin (120 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Colds, sinuses, influenza and other chest complaints, antiparasitic powder applied to sores, fever, respiratory ailments
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7 2) http://www.plantzAfrica.com/plantwxyz/warburg.htm
Curator

Record - 3 of 10 [TOP]

Compound ID	2802
Compound Structure
Plant Source	Warbugia salutaris (Bertol. f.) Chiov Common Name:Pepper - Bark Tree
Source Family	Canellaceae
Origin	Africa
Plant Part Used	Bark or root bark
Extract	Dichloromethane bark extract
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium bovis BCG
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Colds, sinuses, influenza and other chest complaints, antiparasitic powder applied to sores, fever, respiratory ailments
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Clarkson C, Madikane EV, Hansen SH, Smith PJ, Jaroszewski JW.HPLC-SPE-NMR characterization of sesquiterpenes in an antimycobacterial fraction from Warburgia salutaris.Planta Med. 2007 Jun;73(6):578-84 2) http://www.plantzAfrica.com/plantwxyz/warburg.htm
Curator

Record - 4 of 10 [TOP]

Compound ID

3367

Compound Structure

Plant Source

Canella winterana Common Name:NR

Source Family

Canellaceae

Origin

Guadeloupe

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

Bactec: 100 µg/ml, 7H11 agar: 200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Canellal

PubChem ID

325604

Ethnomedicinal Information

Antimycobacterial

PubMed ID [Source Literature]

9626931

Extract Preparation

The dried powdered material was moistened with 25 % NH₄OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH₄OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na₂SO₄. The organic extracts were evaporated and subjected to chromatography on silica gel

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Sesquiterpene, Aldehyde, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium

Cytotoxicity Assay [AID]

Molecular Weight

248.141

Molecular Formula

C₁₅H₂₀O₃

SMILES

OC1(C2(C(C(=C)C(CC2)C)CC=C1C=O)C)C=O

XLogP

2.567

PSA

54.370

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

Curator

Wvarsha, rachanake

Record - 5 of 10 [TOP]

Compound ID

3368

Compound Structure

Plant Source

Canella winterana Common Name:NR

Source Family

Canellaceae

Origin

Guadeloupe

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium 733

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

Bactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Canellal

PubChem ID

325604

Ethnomedicinal Information

Antimycobacterial

PubMed ID [Source Literature]

9626931

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Sesquiterpene, Aldehyde, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium

Cytotoxicity Assay [AID]

Molecular Weight

248.141

Molecular Formula

C₁₅H₂₀O₃

SMILES

OC1(C2(C(C(=C)C(CC2)C)CC=C1C=O)C)C=O

XLogP

2.567

PSA

54.370

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Wvarsha, rachanake

Record - 6 of 10 [TOP]

Compound ID

3369

Compound Structure

Plant Source

Canella winterana Common Name:NR

Source Family

Canellaceae

Origin

Guadeloupe

Plant Part Used

Extract

Target Bacteria

Mycobacterium kansasii (Clinical isolate 94 - 069)

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

Bactec: 100 µg/ml, 7H11 agar: 200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Canellal

PubChem ID

325604

Ethnomedicinal Information

Antimycobacterial

PubMed ID [Source Literature]

9626931

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Sesquiterpene, Aldehyde, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium

Cytotoxicity Assay [AID]

Molecular Weight

248.141

Molecular Formula

C₁₅H₂₀O₃

SMILES

OC1(C2(C(C(=C)C(CC2)C)CC=C1C=O)C)C=O

XLogP

2.567

PSA

54.370

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Wvarsha, rachanake

Record - 7 of 10 [TOP]

Compound ID	3529
Compound Structure	NR
Plant Source	Canella winterana Common Name:NR
Source Family	Canellaceae
Origin	Guadeloupe
Plant Part Used	NR
Extract	NR
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	NR
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	Bactec: 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Canella oil (Mixture)
PubChem ID	NR
Ethnomedicinal Information	Antimycobacterial
PubMed ID [Source Literature]	9626931
Extract Preparation	The dried powdered material was moistened with 25 % NH₄OH, and extracted by Chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH₄OH, and extracted with Chloroform. The organic phase was washed with water, and dried over Na₂SO₄. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73
Curator	Wvarsha, rachanake

Record - 8 of 10 [TOP]

Compound ID	3530
Compound Structure	NR
Plant Source	Canella winterana Common Name:NR
Source Family	Canellaceae
Origin	Guadeloupe
Plant Part Used	NR
Extract	NR
Target Bacteria	Mycobacterium avium 733
Assay / Test Done	NR
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	Bactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Canella oil (Mixture)
PubChem ID	NR
Ethnomedicinal Information	Antimycobacterial
PubMed ID [Source Literature]	9626931
Extract Preparation	The dried powdered material was moistened with 25 % NH₄OH, and extracted by Chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH₄OH, and extracted with Chloroform. The organic phase was washed with water, and dried over Na₂SO₄. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73
Curator	Wvarsha, rachanake

Record - 9 of 10 [TOP]

Compound ID	3531
Compound Structure	NR
Plant Source	Canella winterana Common Name:NR
Source Family	Canellaceae
Origin	Guadeloupe
Plant Part Used	NR
Extract	NR
Target Bacteria	Mycobacterium kansasii (Clinical isolate 94 - 069)
Assay / Test Done	NR
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	Bactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Canella oil (Mixture)
PubChem ID	NR
Ethnomedicinal Information	Antimycobacterial
PubMed ID [Source Literature]	9626931
Extract Preparation	The dried powdered material was moistened with 25 % NH₄OH, and extracted by Chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH₄OH, and extracted with Chloroform. The organic phase was washed with water, and dried over Na₂SO₄. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73
Curator	Wvarsha, rachana-ke

Record - 10 of 10 [TOP]

Compound ID

4128

Compound Structure

Plant Source

Warburgia ugandensis Common Name:

Source Family

Canellaceae

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium aurum and Mycobacterium phlei

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Ugandensidial

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Sesquiterpene, Aldehyde, Acetyl, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

308.162

Molecular Formula

C₁₇H₂₄O₅

SMILES

CC1(C)CCC[C@@]2(C)C1[C@H](OC(=O)C)C=C(C=O)[C@]2(O)C=O

XLogP

3.144

PSA

80.670

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) Rogoza, L. N.; Salakhutdinov, N. F.; Tolstikov, G. A. Anti-tubercular Activity of Natural Products: Recent Developments. In Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry; Tiwari, V. K. Ed.; Research Signpost: India, 2011; pp 103-120

Curator

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