BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 12 [TOP]

Compound ID	1874
Compound Structure
Plant Source	Humulus lupulus L. Common Name:Hops (English)
Source Family	Cannabaceae
Origin	India, USA
Plant Part Used	Flower
Extract	Water, ethanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stomach ache, diuretic, antiseptic, indigestion, tonic, sedative, nervous conditions, bacteriostatic, random screening
PubMed ID [Source Literature]	16695763
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gottshall RY, Lucas EH, Lickfeldt A, Roberts JM.The occurrence of antibacterial substances active against Mycobacterium tuberculosis in seed plants.J Clin Invest. 1949 Sep;28(5 Pt 1):920-3 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 2 of 12 [TOP]

Compound ID	1875
Compound Structure
Plant Source	Humulus lupulus L. Common Name:Hops (English)
Source Family	Cannabaceae
Origin	India, USA
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stomach ache, diuretic, antiseptic, indigestion, tonic, sedative, nervous conditions, bacteriostatic, random screening
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91
Curator

Record - 3 of 12 [TOP]

Compound ID	3215
Compound Structure	NR
Plant Source	Cannabis sativa L. Common Name:Hemp, Indian Hemp (English), Vijayaa, Bhangaa (Sanskrit)
Source Family	Cannabaceae
Origin	India
Plant Part Used	NR
Extract	Essential oil
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	NR
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Leprosy, cough, bronchitis
PubMed ID [Source Literature]	754639
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India 2) Fournier G, Paris MR, Fourniat MC, Quero AM.Bacteriostatic activity of Cannabis sativa L. essential oil Ann Pharm Fr. 1978;36(11-12):603-6
Curator	Reshmi

Record - 4 of 12 [TOP]

Compound ID	3433
Compound Structure
Plant Source	Humulus lupulus L. Common Name:
Source Family	Cannabaceae
Origin	India
Plant Part Used	Flower
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stomach ache, diuretic, antiseptic, indigestion, tonic, sedative, nervous conditions, bacteriostatic, random screening
PubMed ID [Source Literature]	16695763
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Gottshall RY, Lucas EH, Lickfeldt A, Roberts JM. 1949. The occurrence of antibacterial substances active against Mycobacterium tuberculosis in seed plants. J Clin Invest 28: 920-923
Curator

Record - 5 of 12 [TOP]

Compound ID	3434
Compound Structure
Plant Source	Humulus lupulus L. Common Name:
Source Family	Cannabaceae
Origin	India
Plant Part Used	Flower
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stomach ache, diuretic, antiseptic, indigestion, tonic, sedative, nervous conditions, bacteriostatic, random screening
PubMed ID [Source Literature]	16695763
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Gottshall RY, Lucas EH, Lickfeldt A, Roberts JM. 1949. The occurrence of antibacterial substances active against Mycobacterium tuberculosis in seed plants. J Clin Invest 28: 920-923
Curator

Record - 6 of 12 [TOP]

Compound ID	3435
Compound Structure
Plant Source	Humulus lupulus L. Common Name:
Source Family	Cannabaceae
Origin	India
Plant Part Used
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stomach ache, diuretic, antiseptic, indigestion, tonic, sedative, nervous conditions, bacteriostatic, random screening
PubMed ID [Source Literature]	2118130
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91
Curator

Record - 7 of 12 [TOP]

Compound ID

3607

Compound Structure

Plant Source

Humulus lupulus Common Name:

Source Family

Cannabaceae

Origin

Plant Part Used

Whole plant

Extract

Hexane

Target Bacteria

Mycobacterium aurum (Pasteur Institute 104482)

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (1 µg/ml), Isoniazid (2 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Linoleic acid

PubChem ID

5280450

Ethnomedicinal Information

PubMed ID [Source Literature]

15478197

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Fatty acid

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

280.240

Molecular Formula

C₁₈H₃₂O₂

SMILES

OC(=O)CCCCCCC/C=CC/C=CCCCCC

XLogP

7.865

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Stavri M, Schneider R, O'Donnell G, Lechner D, Bucar F, Gibbons S.The antimycobacterial components of hops (Humulus lupulus) and their dereplication.Phytother Res. 2004 Sep;18(9):774-6

Curator

Gppreetha, vikramjitmandal

Record - 8 of 12 [TOP]

Compound ID

3608

Compound Structure

Plant Source

Humulus lupulus Common Name:

Source Family

Cannabaceae

Origin

Plant Part Used

Whole plant

Extract

Hexane

Target Bacteria

Mycobacterium fortuitum (ATCC 6841)

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (4 µg/ml), Isoniazid (0.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Linoleic acid

PubChem ID

5280450

Ethnomedicinal Information

PubMed ID [Source Literature]

15478197

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Fatty acid

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

280.240

Molecular Formula

C₁₈H₃₂O₂

SMILES

OC(=O)CCCCCCC/C=CC/C=CCCCCC

XLogP

7.865

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Stavri M, Schneider R, O'Donnell G, Lechner D, Bucar F, Gibbons S.The antimycobacterial components of hops (Humulus lupulus) and their dereplication.Phytother Res. 2004 Sep;18(9):774-6

Curator

Gppreetha, vikramjitmandal

Record - 9 of 12 [TOP]

Compound ID

3609

Compound Structure

Plant Source

Humulus lupulus Common Name:

Source Family

Cannabaceae

Origin

Plant Part Used

Whole plant

Extract

Hexane

Target Bacteria

Mycobacterium phlei (ATCC 11758)

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (2 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Linoleic acid

PubChem ID

5280450

Ethnomedicinal Information

PubMed ID [Source Literature]

15478197

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Fatty acid

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

280.240

Molecular Formula

C₁₈H₃₂O₂

SMILES

OC(=O)CCCCCCC/C=CC/C=CCCCCC

XLogP

7.865

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Stavri M, Schneider R, O'Donnell G, Lechner D, Bucar F, Gibbons S.The antimycobacterial components of hops (Humulus lupulus) and their dereplication.Phytother Res. 2004 Sep;18(9):774-6

Curator

Gppreetha, vikramjitmandal

Record - 10 of 12 [TOP]

Compound ID

3610

Compound Structure

Plant Source

Humulus lupulus Common Name:

Source Family

Cannabaceae

Origin

Plant Part Used

Whole plant

Extract

Hexane

Target Bacteria

Mycobacterium smegmatis (ATCC 14468)

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (0.5 µg/ml), Isoniazid (2 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Linoleic acid

PubChem ID

5280450

Ethnomedicinal Information

PubMed ID [Source Literature]

15478197

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Fatty acid

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

280.240

Molecular Formula

C₁₈H₃₂O₂

SMILES

OC(=O)CCCCCCC/C=CC/C=CCCCCC

XLogP

7.865

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Stavri M, Schneider R, O'Donnell G, Lechner D, Bucar F, Gibbons S.The antimycobacterial components of hops (Humulus lupulus) and their dereplication.Phytother Res. 2004 Sep;18(9):774-6

Curator

Gppreetha, vikramjitmandal

Record - 11 of 12 [TOP]

Compound ID

3611

Compound Structure

Plant Source

Humulus lupulus Common Name:

Source Family

Cannabaceae

Origin

Plant Part Used

Whole plant

Extract

Hexane

Target Bacteria

Mycobacterium aurum (Pasteur Institute 104482)

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (1 µg/ml), Isoniazid (2 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Oleic acid

PubChem ID

445639

Ethnomedicinal Information

PubMed ID [Source Literature]

15478197

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Fatty acid

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

282.256

Molecular Formula

C₁₈H₃₄O₂

SMILES

OC(=O)CCCCCCC/C=CCCCCCCCC

XLogP

8.192

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Stavri M, Schneider R, O'Donnell G, Lechner D, Bucar F, Gibbons S.The antimycobacterial components of hops (Humulus lupulus) and their dereplication.Phytother Res. 2004 Sep;18(9):774-6

Curator

Gppreetha, vikramjitmandal

Record - 12 of 12 [TOP]

Compound ID

3612

Compound Structure

Plant Source

Humulus lupulus Common Name:

Source Family

Cannabaceae

Origin

Plant Part Used

Whole plant

Extract

Hexane

Target Bacteria

Mycobacterium smegmatis (ATCC 14468)

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (0.5 µg/ml), Isoniazid (2 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Oleic acid

PubChem ID

445639

Ethnomedicinal Information

PubMed ID [Source Literature]

15478197

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Fatty acid

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

282.256

Molecular Formula

C₁₈H₃₄O₂

SMILES

OC(=O)CCCCCCC/C=CCCCCCCCC

XLogP

8.192

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Stavri M, Schneider R, O'Donnell G, Lechner D, Bucar F, Gibbons S.The antimycobacterial components of hops (Humulus lupulus) and their dereplication.Phytother Res. 2004 Sep;18(9):774-6

Curator

Gppreetha, vikramjitmandal

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