BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 19 [TOP]

Compound ID	1806
Compound Structure
Plant Source	Garcinia polyantha Oliv. Common Name:
Source Family	Clusiaceae
Origin	Africa
Plant Part Used	Stem bark
Extract	Dichloromethane:Methanol
Target Bacteria	Mycobacterium smegmatis, Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:01 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Wounds, various uses
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Kuete V., Meli A.L., Komguem J., Louh G.N., Tangmouo J.G., Lontsi D., Meyer J.J.M., Lall N.Antimycobacterial, Antibacterial and Antifungal Activities of the Methanolic Extract and Compounds from Garcinia Polyantha. Pharmacologyonline 3 : 87-95 (2007)
Curator

Record - 2 of 19 [TOP]

Compound ID	2133
Compound Structure
Plant Source	Mammea americana L Common Name:
Source Family	Clusiaceae
Origin	India
Plant Part Used	Leaf
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	10 mm
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bitter, resinous and highly toxic to several pests, jam, sauces
PubMed ID [Source Literature]	10925394
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Wright CW.A review of antimycobacterial natural products.Phytother Res. 2000 Aug;14(5):303-22 2) Chopra, R.N., Chopra, I.C., Verma, B.S., 1969. Supplement to the Glossary of Indian Medicinal Plants. Council of Scientific and Industrial Research, New Delhi, India
Curator

Record - 3 of 19 [TOP]

Compound ID	2134
Compound Structure
Plant Source	Mammea americana L Common Name:
Source Family	Clusiaceae
Origin	India
Plant Part Used	Leaf
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bitter, resinous and highly toxic to several pests, jam, sauces
PubMed ID [Source Literature]	10925394
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Wright CW.A review of antimycobacterial natural products.Phytother Res. 2000 Aug;14(5):303-22 2) Chopra, R.N., Chopra, I.C., Verma, B.S., 1969. Supplement to the Glossary of Indian Medicinal Plants. Council of Scientific and Industrial Research, New Delhi, India
Curator

Record - 4 of 19 [TOP]

Compound ID	2170
Compound Structure
Plant Source	Mesua ferrea L Common Name:Ironwood, Mesu (English), Naagakeshara, Naagapushpa (Sanskrit)
Source Family	Clusiaceae
Origin	India
Plant Part Used	Twig
Extract	Ethanol (95 %), petroleum ether
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sore throat, cough, asthma
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pongpan A, Chumsri P and Taworasate T .The antimicrobial activity of some Thai Medicinal. Plants. Mahidol Univ J Pharm Sci 1982; 9 4: 88-91 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 5 of 19 [TOP]

Compound ID

1799

Compound Structure

Plant Source

Garcinia mangostana Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Thailand, Malaysia

Plant Part Used

Arils and seed

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampicin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulfate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

9 - Hydroxycalabaxanthone

PubChem ID

Ethnomedicinal Information

Treatment of diarrhea and dysentery and for skin diseases, to lower fever and for urinary disorders

PubMed ID [Source Literature]

12843596

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Xanthanoid, Benzopyran, Prenylated, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

422.173

Molecular Formula

C₂₅H₂₆O₆

SMILES

C1(c(c(cc2c1c(=O)c1c(o2)cc2c(c1O)C=CC(O2)(C)C)O)OC)CCC=C(C)C

XLogP

3.609

PSA

85.220

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Suksamrarn S, Suwannapoch N, Phakhodee W, Thanuhiranlert J, Ratananukul P, Chimnoi N, Suksamrarn A.Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.Chem Pharm Bull (Tokyo). 2003 Jul;51(7):857-9

2) http://www.montosogardens.com/garcinia_mangostana.htm

Curator

Record - 6 of 19 [TOP]

Compound ID

3108

Compound Structure

Plant Source

Calophyllum lanigerum var. austrocoriaceum Common Name:NR

Source Family

Clusiaceae

Origin

Malaysian rain forest

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

8 - 16 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(+)- Calanolide A

PubChem ID

64972

Ethnomedicinal Information

PubMed ID [Source Literature]

16138106

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Coumarin, Benzopyran, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

370.178

Molecular Formula

C₂₂H₂₆O₅

SMILES

O1[C@@H]([C@H]([C@H](O)c2c1c1c(OC(C=C1)(C)C)c1c2oc(=O)cc1CCC)C)C

XLogP

4.029

PSA

55.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Pink R, Hudson A, Mouriès MA, Bendig M.Opportunities and challenges in antiparasitic drug discovery.Nat Rev Drug Discov. 2005 Sep;4(9):727-40

Curator

Reshmi, gppreetha

Record - 7 of 19 [TOP]

Compound ID

1798

Compound Structure

Plant Source

Garcinia mangostana Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Thailand, Malaysia

Plant Part Used

Fruit

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampicin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulfate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Garcinone B

PubChem ID

5495928

Ethnomedicinal Information

Treatment of diarrhea and dysentery and for skin diseases, to lower fever and for urinary disorders

PubMed ID [Source Literature]

12843596

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Xanthonoid, Benzopyran, Prenylated, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

394.142

Molecular Formula

C₂₃H₂₂O₆

SMILES

O1C(C=Cc2c3c(oc4c(c3=O)c(O)c(c(O)c4)CC=C(C)C)cc(O)c12)(C)C

XLogP

2.203

PSA

86.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 8 of 19 [TOP]

Compound ID

1796

Compound Structure

Plant Source

Garcinia mangostana Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Thailand, Malaysia

Plant Part Used

Fruit

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampicin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulfate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Garcinone D

PubChem ID

5495926

Ethnomedicinal Information

Treatment of diarrhea and dysentery and for skin diseases, to lower fever and for urinary disorders

PubMed ID [Source Literature]

12843596

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Prenylated, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

428.184

Molecular Formula

C₂₄H₂₈O₇

SMILES

OC(CCc1c2c(oc3c(c2=O)c(O)c(c(O)c3)CC=C(C)C)cc(O)c1OC)(C)C

XLogP

1.895

PSA

107.220

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 9 of 19 [TOP]

Compound ID

3573

Compound Structure

Plant Source

Garcinia mangostana Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Southeast Asian countries (Thailand, Malaysia)

Plant Part Used

Fruit hull, fresh aril, seed

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulphate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

α - Mangostin

PubChem ID

5281650

Ethnomedicinal Information

Skin infections, wounds and diarrhea, to lower fever and for urinary disorders

PubMed ID [Source Literature]

12843596

Extract Preparation

MeOH extract were obtained from the fresh green fruit hulls of Garcinia mangostana. Pulverized, fresh arils and seeds were extracted throroughly with MeOH and evaporation of the solvent gave crude extract. The crude extract was partitioned between CHCl₃ and H₂O to afford CHCl₃ extract

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Prenylated, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

7H9GC medium

Cytotoxicity Assay [AID]

Molecular Weight

410.173

Molecular Formula

C₂₄H₂₆O₆

SMILES

O1c2c(c(CC=C(C)C)c(OC)c(O)c2)c(=O)c2c1cc(O)c(c2O)CC=C(C)C

XLogP

2.792

PSA

86.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Gppreetha, vikramjitmandal, reshmi

Record - 10 of 19 [TOP]

Compound ID

3575

Compound Structure

Plant Source

Garcinia mangostana L. Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Southeast Asia

Plant Part Used

Fruit hull

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulphate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Demethylcalabaxanthone

PubChem ID

509270

Ethnomedicinal Information

Skin infections, wounds and diarrhea

PubMed ID [Source Literature]

12843596

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Xanthonoid, Prenylated, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

378.147

Molecular Formula

C₂₃H₂₂O₅

SMILES

O1C(C=Cc2c1cc1oc3c(c(=O)c1c2O)c(CC=C(C)C)c(O)cc3)(C)C

XLogP

3.163

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Gppreetha, vikramjitmandal, reshmi

Record - 11 of 19 [TOP]

Compound ID

3577

Compound Structure

Plant Source

Garcinia mangostana L. Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Southeast Asia

Plant Part Used

Fruit hull

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulphate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Trapezifolixanthone

PubChem ID

188341

Ethnomedicinal Information

Skin infections, wounds and diarrhea

PubMed ID [Source Literature]

12843596

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Xanthonoid, Benzopyran, Prenylated, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

378.147

Molecular Formula

C₂₃H₂₂O₅

SMILES

O1C(C=Cc2c1c(c1oc3c(c(=O)c1c2O)cccc3O)CC=C(C)C)(C)C

XLogP

3.166

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Gppreetha, vikramjitmandal, reshmi

Record - 12 of 19 [TOP]

Compound ID

3578

Compound Structure

Plant Source

Garcinia mangostana L. Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Southeast Asia

Plant Part Used

Fruit hull

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulphate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

β - mangostin

PubChem ID

Ethnomedicinal Information

Skin infections, wounds and diarrhea

PubMed ID [Source Literature]

12843596

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Prenylated, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

424.189

Molecular Formula

C₂₅H₂₈O₆

SMILES

O1c2c(c(CC=C(C)C)c(c(O)c2)OC)c(=O)c2c1cc(c(c2O)CC=C(C)C)OC

XLogP

3.311

PSA

75.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Gppreetha, vikramjitmandal, reshmi

Record - 13 of 19 [TOP]

Compound ID

3579

Compound Structure

Plant Source

Garcinia mangostana L. Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Southeast Asia

Plant Part Used

Fruit hull

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulphate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

γ - Mangostin

PubChem ID

5464078

Ethnomedicinal Information

Skin infections, wounds and diarrhea

PubMed ID [Source Literature]

12843596

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Prenylated, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

396.157

Molecular Formula

C₂₃H₂₄O₆

SMILES

O1c2c(c(CC=C(C)C)c(O)c(O)c2)c(=O)c2c1cc(O)c(c2O)CC=C(C)C

XLogP

2.702

PSA

97.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Gppreetha, vikramjitmandal, reshmi

Record - 14 of 19 [TOP]

Compound ID

3581

Compound Structure

Plant Source

Garcinia mangostana L. Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Southeast Asia

Plant Part Used

Fruit hull

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulphate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Mangostenol

PubChem ID

Ethnomedicinal Information

Skin infections, wounds and diarrhea

PubMed ID [Source Literature]

12843596

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Ether, Prenylated, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

426.168

Molecular Formula

C₂₄H₂₆O₇

SMILES

O1c2c(c(O)c(c(c2)O)CC(C(=C)C)O)c(=O)c2c1cc(O)c(c2CC=C(C)C)OC

XLogP

1.226

PSA

107.220

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Gppreetha, vikramjitmandal, reshmi

Record - 15 of 19 [TOP]

Compound ID

3583

Compound Structure

Plant Source

Garcinia mangostana L. Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Southeast Asia

Plant Part Used

Fruit hull

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulphate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Mangostanin

PubChem ID

5495929

Ethnomedicinal Information

Skin infections, wounds and diarrhea

PubMed ID [Source Literature]

12843596

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Xanthanoid, Benzopyran, Prenylated, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

408.157

Molecular Formula

C₂₄H₂₄O₆

SMILES

O1C(C=Cc2c1cc1oc3c(c(CC=C(C)C)c(OC)c(O)c3)c(=O)c1c2O)(C)C

XLogP

2.719

PSA

75.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Gppreetha, vikramjitmandal, reshmi

Record - 16 of 19 [TOP]

Compound ID

3585

Compound Structure

Plant Source

Garcinia mangostana L. Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Southeast Asia

Plant Part Used

Fruit hull

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulphate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Mangostenone A

PubChem ID

509267

Ethnomedicinal Information

Skin infections, wounds and diarrhea

PubMed ID [Source Literature]

12843596

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Pentacyclic, Xanthonoid, Benzopyran, Prenylated, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

460.189

Molecular Formula

C₂₈H₂₈O₆

SMILES

O1C(C=Cc2c3oc4c(c(=O)c3c(c(O)c12)CC=C(C)C)c(O)c1c(OC(C=C1)(C)C)c4)(C)C

XLogP

3.603

PSA

75.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Gppreetha, vikramjitmandal, reshmi

Record - 17 of 19 [TOP]

Compound ID

3586

Compound Structure

Plant Source

Garcinia mangostana L. Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Southeast Asia

Plant Part Used

Fruit hull

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulphate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Tovophyllin B

PubChem ID

509268

Ethnomedicinal Information

Skin infections, wounds and diarrhea

PubMed ID [Source Literature]

12843596

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Pentacyclic, Xanthonoid, Benzopyran, Prenylated, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

460.189

Molecular Formula

C₂₈H₂₈O₆

SMILES

O1C(C=Cc2c3c(oc4c(c3=O)c(O)c3c(OC(C=C3)(C)C)c4)c(c(O)c12)CC=C(C)C)(C)C

XLogP

3.603

PSA

75.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Gppreetha, vikramjitmandal, reshmi

Record - 18 of 19 [TOP]

Compound ID

3587

Compound Structure

Plant Source

Garcinia mangostana L. Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Southeast Asia

Plant Part Used

Fruit hull

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulphate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Mangostanol

PubChem ID

10048103

Ethnomedicinal Information

Skin infections, wounds and diarrhea

PubMed ID [Source Literature]

12843596

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Xanthonoid, Benzopyran, Prenylated, Phenol, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

426.168

Molecular Formula

C₂₄H₂₆O₇

SMILES

O1C(C(O)Cc2c1cc1oc3c(c(=O)c1c2O)c(CC=C(C)C)c(OC)c(O)c3)(C)C

XLogP

1.883

PSA

96.220

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Gppreetha, vikramjitmandal, reshmi

Record - 19 of 19 [TOP]

Compound ID

1805

Compound Structure

Plant Source

Garcinia mangostana Common Name:Mangosteen

Source Family

Clusiaceae

Origin

Thailand, Malaysia

Plant Part Used

Fruit

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampicin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin sulfate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Mangostinone

PubChem ID

6478778

Ethnomedicinal Information

Treatment of diarrhea and dysentery and for skin diseases, lower fever and for urinary disorders

PubMed ID [Source Literature]

12843596

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Xanthonoid, Prenylated, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

380.162

Molecular Formula

C₂₃H₂₄O₅

SMILES

O1c2c(c(O)c(C/C=C(/CCC=C(C)C)C)c(O)c2)c(=O)c2c1c(O)ccc2

XLogP

3.588

PSA

77.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

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