BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 39 [TOP]

Compound ID	1191
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	78 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 2 of 39 [TOP]

Compound ID	1192
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Hexane
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	312.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 3 of 39 [TOP]

Compound ID	1193
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Ethyl acetate soluble
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	625 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 4 of 39 [TOP]

Compound ID	1194
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Methanol
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 5 of 39 [TOP]

Compound ID	1299
Compound Structure
Plant Source	Buchenavia grandis Ducke Common Name:
Source Family	Combretaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 6 of 39 [TOP]

Compound ID	1511
Compound Structure
Plant Source	Combretum assimile Eichl Common Name:
Source Family	Combretaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 7 of 39 [TOP]

Compound ID	1512
Compound Structure
Plant Source	Combretum erythrophyllum (Burch)Sond. Common Name:River Bush Willow
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Leaf
Extract	Water, methanol
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (2.00 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Abdominal pain, venereal diseases
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 8 of 39 [TOP]

Compound ID	1513
Compound Structure
Plant Source	Combretum erythrophyllum (Burch)Sond. Common Name:River Bush Willow
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Leaf
Extract	Water, methanol
Target Bacteria	Mycobacterium tuberculosis 2 (Clinical isolates resistant to Streptomycin, Rifampin, Ethambutol, Isoniazid)
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (100 µg/ml), Isoniazid (4.6 µg/ml), Ethambutol (12 µg/ml), Streptomycin (120 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Abdominal pain, venereal diseases
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 9 of 39 [TOP]

Compound ID

1514

Compound Structure

Plant Source

Combretum imberbe Wawra Common Name:Leadwood

Source Family

Combretaceae

Origin

Africa

Plant Part Used

Leaf

Extract

Target Bacteria

Mycobacterium fortuitum

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

1.56 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Imberbic acid

PubChem ID

Ethnomedicinal Information

Combretum species used for chest coughs, fever, infections

PubMed ID [Source Literature]

12657301

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Pentacyclic, Triterpene, Hydroxy, Acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

472.355

Molecular Formula

C₃₀H₄₈O₄

SMILES

C1([C@H]2[C@@]([C@@H]3[C@@](CC2)([C@]2(C(=CC3)[C@H]3[C@@](CC2)(CC[C@](C3)(C(=O)O)C)C)C)C)([C@H](C[C@@H]1O)O)C)(C)C

XLogP

7.389

PSA

77.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Katerere DR, Gray AI, Nash RJ, Waigh RD.Antimicrobial activity of pentacyclic triterpenes isolated from African Combretaceae.Phytochemistry. 2003 May;63(1):81-8

Curator

Record - 10 of 39 [TOP]

Compound ID	1515
Compound Structure
Plant Source	Combretum kraussii Hochst. Common Name:Forest bushwillow
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Leaf
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1560 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Various stomach complaints, fever, wounds and inflammation
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://www.plantzAfrica.com/plantcd/combretkraus.htm
Curator

Record - 11 of 39 [TOP]

Compound ID	1516
Compound Structure
Plant Source	Combretum kraussii Hochst. Common Name:Forest Bushwillow
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Leaf
Extract	Ethanol
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	195 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Various stomach complaints, fever, wounds and inflammation
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://www.plantzAfrica.com/plantcd/combretkraus.htm
Curator

Record - 12 of 39 [TOP]

Compound ID	1517
Compound Structure
Plant Source	Combretum kraussii Hochst. Common Name:Forest Bushwillow
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Bark
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1560 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Various stomach complaints, fever, wounds and inflammation
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://www.plantzAfrica.com/plantcd/combretkraus.htm
Curator

Record - 13 of 39 [TOP]

Compound ID	1518
Compound Structure
Plant Source	Combretum kraussii Hochst. Common Name:Forest Bushwillow
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Bark
Extract	Ethanol
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	195 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Various stomach complaints, fever, wounds and inflammation
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://www.plantzAfrica.com/plantcd/combretkraus.htm
Curator

Record - 14 of 39 [TOP]

Compound ID	1519
Compound Structure
Plant Source	Combretum kraussii Hochst. Common Name:Forest Bushwillow
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Root
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	780 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Various stomach complaints, fever, wounds and inflammation
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://www.plantzAfrica.com/plantcd/combretkraus.htm
Curator

Record - 15 of 39 [TOP]

Compound ID	1520
Compound Structure
Plant Source	Combretum kraussii Hochst. Common Name:Forest Bushwillow
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Root
Extract	Ethanol
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	195 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Various stomach complaints, fever, wounds and inflammation
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://www.plantzAfrica.com/plantcd/combretkraus.htm
Curator

Record - 16 of 39 [TOP]

Compound ID	1521
Compound Structure
Plant Source	Combretum laxum Jacquin Common Name:
Source Family	Combretaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 17 of 39 [TOP]

Compound ID	1522
Compound Structure
Plant Source	Combretum molle R. Br. Ex G. Don Common Name:Velvet Leaf Willow, Velvet Leaf Combretum, Velvet Bush Willow
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Bark
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, tuberculosis, juice drunk to treat chest complaints
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Hutchings, A., Johnson, C.Glimpses of a Xhosa herbal.Veld & flora.June 1986. v. 72 (2) 2) Lall N, Meyer JJ.In vitro inhibition of drug-resistant and drug-sensitive strains of Mycobacterium tuberculosis by ethnobotanically selected South African plants.J Ethnopharmacol. 1999 Sep;66(3):347-54 3) http://www.worldagroforestry.org/treedb2/AFTPDFS/Combretum_molle.pdf
Curator

Record - 18 of 39 [TOP]

Compound ID

1523

Compound Structure

Plant Source

Combretum molle R. Br. Ex G. Don Common Name:Velvet Leaf Willow, Velvet Leaf Combretum, Velvet Bush Willow

Source Family

Combretaceae

Origin

Africa

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

0.6 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Punicalagin

PubChem ID

16149716

Ethnomedicinal Information

Cough, tuberculosis, juice drunk to treat chest complaints

PubMed ID [Source Literature]

15110681

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Polyphenol, Ellagitannin, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

0.000

Molecular Formula

C₄₈H₂₈O₃₀

SMILES

O1[C@H]2[C@@H](OC(=O)c3c(c4c5c6c7c(c(c8c(C(=O)OC2)cc(O)c(O)c8O)c(O)c(O)c7oc5=O)c(=O)oc6c(O)c4O)c(O)c(O)c(O)c3)[C@@H]2OC(=O)c3c(c4c(C(=O)O[C@H]2[C@H]1O)cc(O)c(O)c4O)c(O)c(O)c(O)c3

XLogP

0.000

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Okunade AL, Elvin-Lewis MP, Lewis WH.Natural antimycobacterial metabolites: current status.Phytochemistry. 2004 Apr;65(8):1017-32

Curator

Record - 19 of 39 [TOP]

Compound ID	1524
Compound Structure
Plant Source	Combretum spp Common Name:Leadwood
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Stem bark, root bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, cough, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) http://www.bradturnsgreen.com/Wood%20Status%20List.pdf
Curator

Record - 20 of 39 [TOP]

Compound ID	1528
Compound Structure
Plant Source	Conocarpus erectus L. Common Name:Button Mangrove
Source Family	Combretaceae
Origin	Puerto Rico
Plant Part Used	Leaf
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Middlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)	Rifampin
Inhibition [%]	68 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Anti - quorum sensing activity
PubMed ID [Source Literature]	11746852
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42 2) http://plants.usda.gov/java/profile?symbol=COER2 3) Allison L. Adonizio, Kelsey Downum, Bradley C. Bennett and Kalai Mathee Anti-quorum sensing activity of medicinal plants in southern Florida Journal of Ethnopharmacology Volume 105, Issue 3, 24 May 2006, Pages 427-435.
Curator

Record - 21 of 39 [TOP]

Compound ID	1529
Compound Structure
Plant Source	Conocarpus erectus L. Common Name:Button Mangrove
Source Family	Combretaceae
Origin	Puerto Rico
Plant Part Used	Stem
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Middlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)	Rifampin
Inhibition [%]	40 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Anti - quorum sensing activity
PubMed ID [Source Literature]	11746852
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42 2) http://plants.usda.gov/java/profile?symbol=COER2 3) Allison L. Adonizio, Kelsey Downum, Bradley C. Bennett and Kalai Mathee Anti-quorum sensing activity of medicinal plants in southern Florida Journal of Ethnopharmacology Volume 105, Issue 3, 24 May 2006, Pages 427-435.
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Record - 22 of 39 [TOP]

Compound ID	1983
Compound Structure
Plant Source	Laguncularia racemosa(L.) Gaertn. F. Common Name:White Mangrove
Source Family	Combretaceae
Origin	Puerto Rico
Plant Part Used	Leaf
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Middlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)	Rifampin
Inhibition [%]	36 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	11746852
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42 2) http://plants.usda.gov/java/profile?symbol=LARA2
Curator

Record - 23 of 39 [TOP]

Compound ID	2089
Compound Structure
Plant Source	Lumnitzera littorea Voigt Common Name:
Source Family	Combretaceae
Origin	India
Plant Part Used	Twig
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Piles
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pongpan A, Chumsri P and Taworasate T .The antimicrobial activity of some Thai Medicinal Plants. Mahidol Univ J Pharm Sci 1982; 9 4: 88-91
Curator

Record - 24 of 39 [TOP]

Compound ID	2702
Compound Structure
Plant Source	Terminalia alata Heyne ex Roth syn. Terminalia tomentosa Wt. & Arn. Common Name:Laurel (English), Asana (Sanskrit)
Source Family	Combretaceae
Origin	India
Plant Part Used	Bark
Extract	Methanol
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Chloramphenicol
Inhibition [%]
Activity [MIC] µg/ml	300000 µg/ml of dried plant material
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, fever, dysentery, haematuria, anaemia, sores, wounds, stomach ache
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Taylor RS, Edel F, Manandhar NP, Towers GH.Antimicrobial activities of southern Nepalese medicinal plants.J Ethnopharmacol. 1996 Feb;50(2):97-102 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
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Record - 25 of 39 [TOP]

Compound ID	2703
Compound Structure
Plant Source	Terminalia avicennioides Guill. & Perr. Common Name:
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Mistletoes, root bark, fruit
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	78 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, hemoptysis, tuberculosis, sore throat, diarrhea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) Mann A, Gbate M, Nda-Umar A. Medicinal and Economic Plants of Nupeland. Bida, Niger State, Nigeria: Jube-Evans Books and Publications; 2003. p. 276
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