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                  Page - 1 of 1                  Record - 1 of 14   [TOP]
Compound ID1544
Compound Structure
Plant SourceCostus speciosus (J. Koenig) Sm.     Common Name:Crepe Ginger (English), Kushtha (Sanskrit)
Source FamilyCostaceae
OriginMalaysia
Plant Part UsedStem, flower
ExtractMethanol
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneColorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml800 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationCough
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Chooi, O.H., 2004. Tumbuhan Liar, Khasiat Ubatan dan Kegunaan Lain. Utusan Publications and Distributors Sdn Bhd, Kuala Lumpur, Malaysia

2) http://www.flowersofIndia.net/catalog/slides/Crepe%20Ginger.html

Curator

                  Record - 2 of 14   [TOP]
Compound ID3061
Compound Structure
DOWNLOAD:
Plant SourceCostus     Common Name:NR
Source FamilyCostaceae
OriginNR
Plant Part UsedRoot
ExtractNR
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedDehydrocostus lactone
PubChem ID   73174
Ethnomedicinal InformationNR
PubMed ID [Source Literature]9784148
Extract PreparationNR
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Sesquiterpene, Lactone
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight230.131
Molecular FormulaC15H18O2
SMILESO1[C@@H]2[C@@H]3[C@@H](CCC3=C)C(=C)CC[C@H]2C(=C)C1=O
XLogP2.451
PSA26.300
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings3
No. of N0
No. of O2
No. of S0
Reference(s)1) Cantrell CL, Nuņez IS, Castaņeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG.Antimycobacterial activities of dehydrocostus lactone and its oxidation products.J Nat Prod. 1998 Oct;61(10):1181-6

CuratorFarzana-shamsudeen, gppreetha

                  Record - 3 of 14   [TOP]
Compound ID3062
Compound Structure
DOWNLOAD:
Plant SourceCostus     Common Name:NR
Source FamilyCostaceae
OriginNR
Plant Part UsedRoot
ExtractNR
Target BacteriaMycobacterium avium
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml16 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedDehydrocostus lactone
PubChem ID   73174
Ethnomedicinal InformationNR
PubMed ID [Source Literature]9784148
Extract PreparationNR
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Sesquiterpene, Lactone
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight230.131
Molecular FormulaC15H18O2
SMILESO1[C@@H]2[C@@H]3[C@@H](CCC3=C)C(=C)CC[C@H]2C(=C)C1=O
XLogP2.451
PSA26.300
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings3
No. of N0
No. of O2
No. of S0
Reference(s)1) Cantrell CL, Nuņez IS, Castaņeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG.Antimycobacterial activities of dehydrocostus lactone and its oxidation products.J Nat Prod. 1998 Oct;61(10):1181-6

CuratorFarzana-shamsudeen, gppreetha

                  Record - 4 of 14   [TOP]
Compound ID3063
Compound Structure
DOWNLOAD:
Plant SourceCostus     Common Name:NR
Source FamilyCostaceae
OriginNR
Plant Part UsedNR
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml> 128 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified 3 - Epizaluzanin C
PubChem ID   470970
Ethnomedicinal InformationNR
PubMed ID [Source Literature]9784148
Extract PreparationNR
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Sesquiterpene, Lactone, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight246.126
Molecular FormulaC15H18O3
SMILESO1[C@@H]2[C@@H]3[C@@H](C[C@@H](O)C3=C)C(=C)CC[C@H]2C(=C)C1=O
XLogP1.054
PSA46.530
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings3
No. of N0
No. of O3
No. of S0
Reference(s)1) Cantrell CL, Nuņez IS, Castaņeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG.Antimycobacterial activities of dehydrocostus lactone and its oxidation products.J Nat Prod. 1998 Oct;61(10):1181-6

CuratorFarzana-shamsudeen, gppreetha

                  Record - 5 of 14   [TOP]
Compound ID3064
Compound Structure
DOWNLOAD:
Plant SourceCostus     Common Name:NR
Source FamilyCostaceae
OriginNR
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml> 128 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified7 - α - Hydroxydehydrocostus Lactone
PubChem ID   442258
Ethnomedicinal InformationNR
PubMed ID [Source Literature]9784148
Extract PreparationNR
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Sesquiterpene, Lactone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight246.126
Molecular FormulaC15H18O3
SMILESO1[C@@H]2[C@@H]3[C@@H](CCC3=C)C(=C)CC[C@@]2(O)C(=C)C1=O
XLogP1.293
PSA46.530
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings3
No. of N0
No. of O3
No. of S0
Reference(s)1) Cantrell CL, Nuņez IS, Castaņeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG.Antimycobacterial activities of dehydrocostus lactone and its oxidation products.J Nat Prod. 1998 Oct;61(10):1181-6

CuratorFarzana-shamsudeen, gppreetha

                  Record - 6 of 14   [TOP]
Compound ID3065
Compound Structure
DOWNLOAD:
Plant SourceCostus     Common Name:NR
Source FamilyCostaceae
OriginNR
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml32 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified4-α-(15)-Epoxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]9784148
Extract PreparationNR
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Terpene, Sesquiterpene, Epoxy, Lactone
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight246.126
Molecular FormulaC15H18O3
SMILESC1(=C)[C@H]2[C@@H]([C@@H]3[C@@H](CC1)C(=C)C(=O)O3)[C@]1(CC2)CO1
XLogP1.715
PSA38.830
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings4
No. of N0
No. of O3
No. of S0
Reference(s)1) Cantrell CL, Nuņez IS, Castaņeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG.Antimycobacterial activities of dehydrocostus lactone and its oxidation products.J Nat Prod. 1998 Oct;61(10):1181-6

CuratorFarzana-shamsudeen, gppreetha

                  Record - 7 of 14   [TOP]
Compound ID3066
Compound Structure
DOWNLOAD:
Plant SourceCostus     Common Name:NR
Source FamilyCostaceae
OriginNR
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml32 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified10β(14)-Epoxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]9784148
Extract PreparationNR
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Terpene, Sesquiterpene, Epoxy, Lactone
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight246.126
Molecular FormulaC15H18O3
SMILESC12([C@H]3[C@@H]([C@@H]4[C@@H](CC1)C(=C)C(=O)O4)C(=C)CC3)OC2
XLogP1.504
PSA38.830
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings4
No. of N0
No. of O3
No. of S0
Reference(s)1) Cantrell CL, Nuņez IS, Castaņeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG.Antimycobacterial activities of dehydrocostus lactone and its oxidation products.J Nat Prod. 1998 Oct;61(10):1181-6

CuratorFarzana-shamsudeen, gppreetha

                  Record - 8 of 14   [TOP]
Compound ID3067
Compound Structure
DOWNLOAD:
Plant SourceCostus     Common Name:NR
Source FamilyCostaceae
OriginNR
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml64 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified10α(14)-Epoxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]9784148
Extract PreparationNR
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Sesquiterpene, Epoxy, Lactone
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight246.126
Molecular FormulaC15H18O3
SMILESC12([C@H]3[C@@H]([C@@H]4[C@@H](CC1)C(=C)C(=O)O4)C(=C)CC3)OC2
XLogP1.504
PSA38.830
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings4
No. of N0
No. of O3
No. of S0
Reference(s)1) Cantrell CL, Nuņez IS, Castaņeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG.Antimycobacterial activities of dehydrocostus lactone and its oxidation products.J Nat Prod. 1998 Oct;61(10):1181-6

CuratorFarzana-shamsudeen, gppreetha

                  Record - 9 of 14   [TOP]
Compound ID3068
Compound Structure
DOWNLOAD:
Plant SourceCostus     Common Name:NR
Source FamilyCostaceae
OriginNR
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml64 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified4β(15),10α(14)-diepoxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]9784148
Extract PreparationNR
Chemical Classification [Active Compound]Alicyclic, Pentacyclic,Terpene, Sesquiterpene, Epoxy, Lactone
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight262.121
Molecular FormulaC15H18O4
SMILESC12([C@H]3[C@@H]([C@@H]4[C@@H](CC1)C(=C)C(=O)O4)C1(CC3)OC1)OC2
XLogP0.979
PSA51.360
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count0
No. of Rings5
No. of N0
No. of O4
No. of S0
Reference(s)1) Cantrell CL, Nuņez IS, Castaņeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG.Antimycobacterial activities of dehydrocostus lactone and its oxidation products.J Nat Prod. 1998 Oct;61(10):1181-6

CuratorFarzana-shamsudeen, gppreetha

                  Record - 10 of 14   [TOP]
Compound ID3069
Compound Structure
DOWNLOAD:
Plant SourceCostus     Common Name:NR
Source FamilyCostaceae
OriginNR
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml128 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified4α(15),10α(14)Diepoxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]9784148
Extract PreparationNR
Chemical Classification [Active Compound]Alicyclic, Pentacyclic, Terpene, Sesquiterpene, Epoxy, Lactone
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight262.121
Molecular FormulaC15H18O4
SMILESC12([C@H]3[C@@H]([C@@H]4[C@@H](CC1)C(=C)C(=O)O4)C1(CC3)CO1)OC2
XLogP0.979
PSA51.360
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count0
No. of Rings5
No. of N0
No. of O4
No. of S0
Reference(s)1) Cantrell CL, Nuņez IS, Castaņeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG.Antimycobacterial activities of dehydrocostus lactone and its oxidation products.J Nat Prod. 1998 Oct;61(10):1181-6

CuratorFarzana-shamsudeen, gppreetha

                  Record - 11 of 14   [TOP]
Compound ID3070
Compound Structure
DOWNLOAD:
Plant SourceCostus     Common Name:NR
Source FamilyCostaceae
OriginNR
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml128 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified4α(15),10β(14)-diepoxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]9784148
Extract PreparationNR
Chemical Classification [Active Compound]Alicyclic, Pentacyclic,Terpene, Sesquiterpene, Epoxy, Lactone
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight262.121
Molecular FormulaC15H18O4
SMILESC12([C@H]3[C@@H]([C@@H]4[C@@H](CC1)C(=C)C(=O)O4)C1(CC3)OC1)OC2
XLogP0.979
PSA51.360
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count0
No. of Rings5
No. of N0
No. of O4
No. of S0
Reference(s)1) Cantrell CL, Nuņez IS, Castaņeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG.Antimycobacterial activities of dehydrocostus lactone and its oxidation products.J Nat Prod. 1998 Oct;61(10):1181-6

CuratorFarzana-shamsudeen, gppreetha

                  Record - 12 of 14   [TOP]
Compound ID3071
Compound Structure
DOWNLOAD:
Plant SourceCostus     Common Name:NR
Source FamilyCostaceae
OriginNR
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedMicheliolide
PubChem ID   442279
Ethnomedicinal InformationNR
PubMed ID [Source Literature]9784148
Extract PreparationNR
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Sesquiterpene, Lactone, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight248.141
Molecular FormulaC15H20O3
SMILESO1[C@@H]2[C@H]3[C@](O)(CCC3=C(CC[C@H]2C(=C)C1=O)C)C
XLogP1.233
PSA46.530
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings3
No. of N0
No. of O3
No. of S0
Reference(s)1) Cantrell CL, Nuņez IS, Castaņeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG.Antimycobacterial activities of dehydrocostus lactone and its oxidation products.J Nat Prod. 1998 Oct;61(10):1181-6

CuratorFarzana-shamsudeen, gppreetha

                  Record - 13 of 14   [TOP]
Compound ID3072
Compound Structure
DOWNLOAD:
Plant SourceCostus     Common Name:NR
Source FamilyCostaceae
OriginNR
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml128 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedPumilin
PubChem ID   6436294
Ethnomedicinal InformationNR
PubMed ID [Source Literature]9784148
Extract PreparationNR
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Sesquiterpene, Lactone , Acyl, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight374.137
Molecular FormulaC20H22O7
SMILESO1[C@H]2[C@@H]([C@@H](O)[C@H](OC(=O)/C(=CC)/C)C(=C3[C@]2(O)C(=CC3=O)C)C)C(=C)C1=O
XLogP-0.432
PSA110.130
H-bond Donor2
H-bond Acceptor7
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O7
No. of S0
Reference(s)1) Cantrell CL, Nuņez IS, Castaņeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG.Antimycobacterial activities of dehydrocostus lactone and its oxidation products.J Nat Prod. 1998 Oct;61(10):1181-6

CuratorFarzana-shamsudeen, gppreetha

                  Record - 14 of 14   [TOP]
Compound ID3073
Compound Structure
DOWNLOAD:
Plant SourceCostus     Common Name:NR
Source FamilyCostaceae
OriginNR
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium avium
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml128 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedPumilin
PubChem ID   6436294
Ethnomedicinal Information
PubMed ID [Source Literature]9784148
Extract PreparationNR
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Sesquiterpene, Lactone , Acyl, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]
Molecular Weight374.137
Molecular FormulaC20H22O7
SMILESO1[C@H]2[C@@H]([C@@H](O)[C@H](OC(=O)/C(=CC)/C)C(=C3[C@]2(O)C(=CC3=O)C)C)C(=C)C1=O
XLogP-0.432
PSA110.130
H-bond Donor2
H-bond Acceptor7
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O7
No. of S0
Reference(s)1) Cantrell CL, Nuņez IS, Castaņeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG.Antimycobacterial activities of dehydrocostus lactone and its oxidation products.J Nat Prod. 1998 Oct;61(10):1181-6

Curator


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