BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 14 [TOP]

Compound ID	1396
Compound Structure
Plant Source	Cayaponia sp. Common Name:
Source Family	Cucurbitaceae
Origin	Peru
Plant Part Used	Leaf, stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 2 of 14 [TOP]

Compound ID	1460
Compound Structure
Plant Source	Citrullus colocynthis Schrad. Common Name:Colocynth Bitter Apple (English), Indravaaruni, Indravalli (Sanskrit)
Source Family	Cucurbitaceae
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculous glands of neck, asthma, bronchitis, leprosy
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91 2) Sharma, S.K., 1998. Medicinal Plants Used in Ayurveda. National Academy of Ayurveda, Ministry of Health and Family Welfare, Govt. of India, New Delhi, India 3) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 3 of 14 [TOP]

Compound ID	1568
Compound Structure
Plant Source	Cucumis muricatus Wall. syn. Cucumis sativus L. Common Name:Cucumber (English), Trapusha, Trapushi, Tiktakarkatikaa (Sanskrit)
Source Family	Cucurbitaceae
Origin	India
Plant Part Used	Fruit
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	< 1:40 dilution
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Whooping cough
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Megoneisto, Rao, R.R., 1983. Ethnobotanical studies in Nagaland-4. Sixty two medicinal plants used by the Angami Nagas. Journal of Economic Taxonomy and Botany 4, 167–172.
Curator

Record - 4 of 14 [TOP]

Compound ID	1569
Compound Structure
Plant Source	Cucurbita maxima Duchesne Common Name:Red Gourd, Red Pumpkin (English), Peeta Kuushmaanda, Kuushmaandaka (Sanskrit)
Source Family	Cucurbitaceae
Origin	India
Plant Part Used	Fruit
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	< 1:20 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diuretic, cures kapha, tonic, migraine, inflammation, boils, neuralgia
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 5 of 14 [TOP]

Compound ID	1570
Compound Structure
Plant Source	Cucurbita pepo L. Common Name:Pumpkin, Marrow (English)
Source Family	Cucurbitaceae
Origin	India
Plant Part Used	Fruit
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium phlei
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, bronchitis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Frisbey, A., Roberts, J.M., Jennings, J.C., Gottshall, R.Y., Lucas, E.H., 1953. The occurrence of antibacterial substances in seed plants with special reference to Mycobacterium tuberculosis. Michigan State University Agricultural Applied Science Quaternary Bulletin 35, 392–404 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 6 of 14 [TOP]

Compound ID	1835
Compound Structure
Plant Source	Gurania spinulosa (Poepp. & Endl.) Cogn Common Name:
Source Family	Cucurbitaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 7 of 14 [TOP]

Compound ID	2088
Compound Structure
Plant Source	Luffa operculata (L.) Cogniaux Common Name:
Source Family	Cucurbitaceae
Origin	Peru
Plant Part Used	Whole plant
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 8 of 14 [TOP]

Compound ID	2194
Compound Structure
Plant Source	Momordica charantia L. Common Name:Bitter Gourd, Balsam Pear, Carilla (English), Kaaravellaka, Kaaravella (Sanskrit)
Source Family	Cucurbitaceae
Origin	India, Kenya
Plant Part Used	Leaf
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium simiae
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	30 mm
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, asthma, bronchitis, expectorant, tuberculosis, pneumonia
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton, S.M., Lau, C., Wright, C.W., 2000. A review of antimicrobial natural products. Phytotherapy Research 14, 303–322
Curator

Record - 9 of 14 [TOP]

Compound ID	2195
Compound Structure
Plant Source	Momordica charantia L. Common Name:Bitter Gourd, Balsam Pear, Carilla (English), Kaaravellaka, Kaaravella (Sanskrit)
Source Family	Cucurbitaceae
Origin	India, Kenya
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2, 1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, asthma, bronchitis, expectorant, tuberculosis, pneumonia
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 10 of 14 [TOP]

Compound ID	2196
Compound Structure
Plant Source	Momordica charantia L. Common Name:Bitter Gourd, Balsam Pear, Carilla (English), Kaaravellaka, Kaaravella (Sanskrit)
Source Family	Cucurbitaceae
Origin	India, Kenya
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium kansasii
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2,1 & 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, asthma, bronchitis, expectorant, tuberculosis, pneumonia
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 11 of 14 [TOP]

Compound ID	2197
Compound Structure
Plant Source	Momordica charantia L. Common Name:Bitter Gourd, Balsam Pear, Carilla (English), Kaaravellaka, Kaaravella (Sanskrit)
Source Family	Cucurbitaceae
Origin	India, Kenya
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium fortuitum
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2,1 & 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, asthma, bronchitis, expectorant, tuberculosis, pneumonia
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 12 of 14 [TOP]

Compound ID	2198
Compound Structure
Plant Source	Momordica charantia L. Common Name:Bitter Gourd, Balsam Pear, Carilla (English), Kaaravellaka, Kaaravella (Sanskrit)
Source Family	Cucurbitaceae
Origin	India, Kenya
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2,1 & 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, asthma, bronchitis, expectorant, tuberculosis, pneumonia
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 13 of 14 [TOP]

Compound ID	2804
Compound Structure
Plant Source	Wilbrandia ebracteata Common Name:
Source Family	Cucurbitaceae
Origin	Brazil
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.015 - 0.05 µg/ml)
Inhibition [%]	90 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pavan FR, Sato DN, Higuchi CT, Santos ACB, Vilegas W, Leite CQE 2009. In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants. Rev Bras Farmacogn 19: 204-206
Curator

Record - 14 of 14 [TOP]

Compound ID	3318
Compound Structure
Plant Source	Luffa cylindrica (L.) Roem. Common Name:
Source Family	Cucurbitaceae
Origin	India
Plant Part Used	Aerial
Extract	Ethanol (80 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Agar Dilution - Streak Assay
Positive Control Used (conc.)	NR
Inhibition [%]	100 %
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Leprosy, bronchitis, expectorant
PubMed ID [Source Literature]	541687
Extract Preparation
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Al-Shamma A, Mitscher LA.Comprehensive survey of indigenous Iraqi plants for potential economic value. 1. Screening results of 327 species for alkaloids and antimicrobial agents.J Nat Prod. 1979 Nov-Dec;42(6):633-42
Curator	Rachana, vikramjitmandal

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