BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 26 [TOP]

Compound ID	1944
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Berry
Extract	Methanol (21.82 %)
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 2 of 26 [TOP]

Compound ID	1945
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Berry
Extract	Methanol (21.82 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 3 of 26 [TOP]

Compound ID	1946
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Leaf
Extract	Hexane, methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (Isoniazid and Ethambutol resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]	13680821
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Jimenez-Arellanes A, Meckes M, Ramirez R, Torres J, Luna-Herrera J.Activity against multidrug-resistant Mycobacterium tuberculosis in Mexican plants used to treat respiratory diseases.Phytother Res. 2003 Sep;17(8):903-8 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 4 of 26 [TOP]

Compound ID	1947
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Leaf
Extract	Hexane, methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (Rifampin resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Jimenez-Arellanes A, Meckes M, Ramirez R, Torres J, Luna-Herrera J.Activity against multidrug-resistant Mycobacterium tuberculosis in Mexican plants used to treat respiratory diseases.Phytother Res. 2003 Sep;17(8):903-8 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 5 of 26 [TOP]

Compound ID	1948
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:40 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 6 of 26 [TOP]

Compound ID	1949
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:40 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 7 of 26 [TOP]

Compound ID	1950
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid (10 µl of mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	50 µg extract/Disc
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 8 of 26 [TOP]

Compound ID

1951

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Low Oxygen Recovery Assay (LORA)

Positive Control Used (conc.)

Inhibition [%]

97.7 %

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Longifolene

PubChem ID

289151

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Terpene, Sesquiterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against mammalian Vero cells (ATCC CCL-81)

Molecular Weight

204.188

Molecular Formula

C₁₅H₂₄

SMILES

C12C3C(C(=C)C1CC3)(CCCC2(C)C)C

XLogP

6.444

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gordien AY, Gray AI, Franzblau SG, Seidel V.Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae).J Ethnopharmacol. 2009 Dec 10;126(3):500-5

2) http://plants.usda.gov/java/profile?symbol=JUCO6

Curator

Record - 9 of 26 [TOP]

Compound ID

1952

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

21.1 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Totarol

PubChem ID

92783

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3([C@H](C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 10 of 26 [TOP]

Compound ID

1953

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Non-replicating Mycobacterium tuberculosis H37Rv

Assay / Test Done

Low Oxygen Recovery Assay (LORA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

23.3 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Totarol

PubChem ID

92783

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3([C@H](C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 11 of 26 [TOP]

Compound ID

1954

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis (Isoniazid - resistant variant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

11 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Totarol

PubChem ID

92783

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3([C@H](C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 12 of 26 [TOP]

Compound ID

1955

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis (Streptomycin - resistant variant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

23.9 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Totarol

PubChem ID

92783

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3([C@H](C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 13 of 26 [TOP]

Compound ID

1956

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis (Moxifloxacin - resistant variant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

17.2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Totarol

PubChem ID

92783

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3([C@H](C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 14 of 26 [TOP]

Compound ID

1957

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis (Rifampin resistant variant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

5.8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Totarol

PubChem ID

92783

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3([C@H](C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 15 of 26 [TOP]

Compound ID

1958

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium aurum, Mycobacterium phlei, Mycobacterium fortuitum, Mycobacterium smegmatis

Assay / Test Done

Broth Microdilution Method (BMM)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

2 - 4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Totarol

PubChem ID

92783

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3([C@H](C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 16 of 26 [TOP]

Compound ID

1959

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Aerial

Extract

Target Bacteria

Mycobacterium aurum

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Trans - Communic Acid

PubChem ID

637125

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Diterpene, Alkene, Acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

302.225

Molecular Formula

C₂₀H₃₀O₂

SMILES

OC(=O)[C@@]1([C@H]2[C@@]([C@H](C(=C)CC2)C/C=C(C)/C=C)(CCC1)C)C

XLogP

6.407

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 17 of 26 [TOP]

Compound ID	1960
Compound Structure
Plant Source	Juniperus excelsa M. Bieb. Common Name:Grecian Juniper
Source Family	Cupressaceae
Origin	India, Saudi Arabia
Plant Part Used	Fruit
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	15.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	10234860
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Topçu G, Erenler R, Cakmak O, Johansson CB, Celik C, Chai HB, Pezzuto JM.Diterpenes from the berries of Juniperus excelsa.Phytochemistry. 1999 Apr;50(7):1195-9 2) http://www.pfaf.org/user/Plant.aspx?LatinName=Juniperus+excelsa
Curator

Record - 18 of 26 [TOP]

Compound ID	1961
Compound Structure
Plant Source	Juniperus excelsa M. Bieb. Common Name:Grecian Juniper
Source Family	Cupressaceae
Origin	India, Saudi Arabia
Plant Part Used	Fruit
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	17 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	10234860
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Topçu G, Erenler R, Cakmak O, Johansson CB, Celik C, Chai HB, Pezzuto JM.Diterpenes from the berries of Juniperus excelsa.Phytochemistry. 1999 Apr;50(7):1195-9 2) http://www.pfaf.org/user/Plant.aspx?LatinName=Juniperus+excelsa
Curator

Record - 19 of 26 [TOP]

Compound ID

1962

Compound Structure

Plant Source

Juniperus excelsa M. Bieb. Common Name:Grecian Juniper

Source Family

Cupressaceae

Origin

India, Saudi Arabia

Plant Part Used

Fruit

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Micro Broth Dilution Method

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

14.4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Juniperexcelsic acid

PubChem ID

490535

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

10234860

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Diterpene, Alkene, Acetyl, Acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against KB cells

Molecular Weight

362.246

Molecular Formula

C₂₂H₃₄O₄

SMILES

O(C1[C@](C2[C@@](C(C(CC2)C)CCC(=C)C=C)(CC1)C)(C)C(=O)O)C(=O)C

XLogP

6.661

PSA

63.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Topçu G, Erenler R, Cakmak O, Johansson CB, Celik C, Chai HB, Pezzuto JM.Diterpenes from the berries of Juniperus excelsa.Phytochemistry. 1999 Apr;50(7):1195-9

2) http://www.pfaf.org/user/Plant.aspx?LatinName=Juniperus+excelsa

Curator

Record - 20 of 26 [TOP]

Compound ID

1963

Compound Structure

Plant Source

Juniperus excelsa M. Bieb. Common Name:Grecian Juniper

Source Family

Cupressaceae

Origin

India, Saudi Arabia

Plant Part Used

Fruit

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Micro Broth Dilution Method

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

15 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sandaracopimaric acid

PubChem ID

221580

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

10234860

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Diterpene, Acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against KB cells

Molecular Weight

302.225

Molecular Formula

C₂₀H₃₀O₂

SMILES

OC(=O)[C@]1([C@H]2[C@@]([C@@H]3C(=C[C@@](CC3)(C)C=C)CC2)(CCC1)C)C

XLogP

6.935

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 21 of 26 [TOP]

Compound ID

1964

Compound Structure

Plant Source

Juniperus excelsa M. Bieb. Common Name:Grecian Juniper

Source Family

Cupressaceae

Origin

India, Saudi Arabia

Plant Part Used

Fruit

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Micro Broth Dilution Method

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

6 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sclareol

PubChem ID

73114

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

10234860

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Diterpene, Alcohol, Alkene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against KB cells

Molecular Weight

308.272

Molecular Formula

C₂₀H₃₆O₂

SMILES

O[C@]1([C@@H]([C@@]2(C(C(CCC2)(C)C)CC1)C)CC[C@](O)(C)C=C)C

XLogP

5.989

PSA

40.460

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 22 of 26 [TOP]

Compound ID

1965

Compound Structure

Plant Source

Juniperus procera Hochst Common Name:Grecian Juniper

Source Family

Cupressaceae

Origin

India, Saudi Arabia

Plant Part Used

Leaf

Extract

Ethanol

Target Bacteria

Mycobacterium smegmatis, Mycobacterium intracellulare, Mycobacterium chelonae, Mycobacterium xenopi

Assay / Test Done

Positive Control Used (conc.)

Streptomycin (10 µg/ml), Isoniazid (10 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(+)-Ferruginol

PubChem ID

403773

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

10925394

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1cc2[C@@]3(C(C(CCC3)(C)C)CCc2cc1C(C)C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) I. Muhammad*, J.S. Mossa, F.S. El-Feraly.Antibacterial diterpenes from the leaves and seeds of Juniperus excelsa M. Bieb.Phytotherapy Research, Volume 6, Issue 5, pages 261–264, September/October 1992

2) Newton SM, Lau C, Wright CW.A review of antimycobacterial natural products.Phytother Res. 2000 Aug;14(5):303-22

3) http://www.pfaf.org/user/Plant.aspx?LatinName=Juniperus+excelsa

Curator

Record - 23 of 26 [TOP]

Compound ID

1966

Compound Structure

Plant Source

Juniperus excelsa M. Bieb. Common Name:Grecian Juniper

Source Family

Cupressaceae

Origin

India, Saudi Arabia

Plant Part Used

Leaf

Extract

Ethanol

Target Bacteria

Mycobacterium smegmatis

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

32 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(-) - Sandaracopimaric acid

PubChem ID

221580

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Diterpene, Acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

302.225

Molecular Formula

C₂₀H₃₀O₂

SMILES

OC(=O)[C@]1([C@H]2[C@@]([C@@H]3C(=C[C@@](CC3)(C)C=C)CC2)(CCC1)C)C

XLogP

6.935

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) I. Muhammad*, J.S. Mossa, F.S. El-Feraly.Antibacterial diterpenes from the leaves and seeds of Juniperus excelsa M. Bieb.Phytotherapy Research, Volume 6, Issue 5, pages 261–264, September/October 1992

2) http://www.pfaf.org/user/Plant.aspx?LatinName=Juniperus+excelsa

Curator

Record - 24 of 26 [TOP]

Compound ID

1967

Compound Structure

Plant Source

Juniperus excelsa M. Bieb. Common Name:Grecian Juniper

Source Family

Cupressaceae

Origin

India, Saudi Arabia

Plant Part Used

Leaf

Extract

Ethanol

Target Bacteria

Mycobacterium smegmatis

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

NR (inactive)

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Hinokiol

PubChem ID

432946

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

302.225

Molecular Formula

C₂₀H₃₀O₂

SMILES

OC1C(C2C(CC1)(c1c(CC2)cc(c(O)c1)C(C)C)C)(C)C

XLogP

5.704

PSA

40.460

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) I. Muhammad*, J.S. Mossa, F.S. El-Feraly.Antibacterial diterpenes from the leaves and seeds of Juniperus excelsa M. Bieb.Phytotherapy Research, Volume 6, Issue 5, pages 261–264, September/October 1992

2) http://www.pfaf.org/user/Plant.aspx?LatinName=Juniperus+excelsa

Curator

Record - 25 of 26 [TOP]

Compound ID

1968

Compound Structure

Plant Source

Juniperus procera Hochst Common Name:African Pencil Cedar, Cedar, East African Cedar, East African Pencil Cedar, Pencil Cedar

Source Family

Cupressaceae

Origin

Saudi Arabia

Plant Part Used

Bark

Extract

Chloroform

Target Bacteria

Mycobacterium intracellulare, Mycobacterium xenopi, Mycobacterium chelonae / chelonei, Mycobacterium smegmatis

Assay / Test Done

Positive Control Used (conc.)

Streptomycin (10 µg/ml), Isoniazid (10 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

2.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(+)-Totarol

PubChem ID

460178

Ethnomedicinal Information

Sore throat, chew fruits

PubMed ID [Source Literature]

10925394

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3(C(C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Newton SM, Lau C, Wright CW.A review of antimycobacterial natural products.Phytother Res. 2000 Aug;14(5):303-22

2) http://www.worldagroforestrycentre.org/sea/Products/AFDbases/af/asp/SpeciesInfo.asp?SpID=1022

Curator

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