| Compound ID | 1616 |
| Compound Structure | |
| Plant Source | Dracophyllum longifolium Common Name:Inanga |
| Source Family | Ericaceae |
| Origin | New Zealand |
| Plant Part Used | Leaf |
| Extract | |
| Target Bacteria | Mycobacterium smegmatis |
| Assay / Test Done | 96 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract |
| Positive Control Used (conc.) | Rifampin (100 µM), Streptomycin (100 µM) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Tuberculosis |
| PubMed ID [Source Literature] | 20537175 |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
|
| Curator | |
| Compound ID | 2199 |
| Compound Structure | |
| Plant Source | Moneses uniflora L. Common Name:Single Delight |
| Source Family | Ericaceae |
| Origin | British Columbia |
| Plant Part Used | Aerial |
| Extract | Methanol |
| Target Bacteria | Mycobacterium tuberculosis, Mycobacterium avium |
| Assay / Test Done | Disk Diffusion Assay |
| Positive Control Used (conc.) | Isoniazid |
| Inhibition [%] | 100 % |
| Activity [MIC] µg/ml | 50 µg extract/Disc |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Treatment of coughs and colds, sore throat |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83
2) http://www.pfaf.org/user/Plant.aspx?LatinName=Moneses+uniflora
|
| Curator | |
| Compound ID | 2338 |
| Compound Structure | |
| Plant Source | Pieris floribunda Common Name: |
| Source Family | Ericaceae |
| Origin | Eastern USA |
| Plant Part Used | Leaf |
| Extract | Water |
| Target Bacteria | Mycobacterium tuberculosis |
| Assay / Test Done | |
| Positive Control Used (conc.) | |
| Inhibition [%] | 100 % |
| Activity [MIC] µg/ml | 1:640 dilution |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Tuberculosis |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Fitzpatrick, F.K.Plant substances achieve against mycobacterium tuberculoses.Antibiotics and Chemotherapy, Vol 4, Pages 528-536
|
| Curator | |
| Compound ID | 2339 |
| Compound Structure | |
| Plant Source | Pieris japonica Common Name:Japanese Pieris |
| Source Family | Ericaceae |
| Origin | China |
| Plant Part Used | Leaf |
| Extract | Water |
| Target Bacteria | Mycobacterium tuberculosis |
| Assay / Test Done | |
| Positive Control Used (conc.) | |
| Inhibition [%] | 100 % |
| Activity [MIC] µg/ml | 1:640 dilution |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Tuberculosis |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Fitzpatrick, F.K.Plant substances achieve against mycobacterium tuberculoses.Antibiotics and Chemotherapy, Vol 4, Pages 528-536
|
| Curator | |
| Compound ID | 2916 |
| Compound Structure | NR |
| Plant Source | Rhododendron anthopogon Common Name:Sunpati |
| Source Family | Ericaceae |
| Origin | 3000 - 4000 masl in Nepal |
| Plant Part Used | Flower, leaf |
| Extract | NR |
| Target Bacteria | Mycobacterium tuberculosis H37Rv |
| Assay / Test Done | Microplate Resazurin Assay (MRA) |
| Positive Control Used (conc.) | Ampicillin, Ciprofloxacin, Isoniazid, Rifampin (MIC range: 0.05 – 0.1 g/ml) |
| Inhibition [%] | NR |
| Activity [MIC] µg/ml | |
| Activity (In terms of dilution) | 0.04 % (v/v) |
| Activity (Zone of inhibition in mm) | NR |
| Active Compound Identified | Essential oil (Mixture) |
| PubChem ID | NR |
| Ethnomedicinal Information | Promotes digestive heat, stimulates appetite and relieves liver disorders |
| PubMed ID [Source Literature] | 20428045 |
| Extract Preparation | Hydro distillation of aerial parts |
| Chemical Classification [Active Compound] | NR |
| Media / Broth Used [Antimicrobial Assay/Test] | NR |
| Cytotoxicity Assay [AID] | NR |
| Reference(s) | 1) Innocenti G, Dall Acqua S, Scialino G, Banfi E, Sosa S, Gurung K, Barbera M, Carrara M.Chemical composition and biological properties of Rhododendron anthopogon essential oil.Molecules. 2010 Mar 31;15(4):2326-38
|
| Curator | KeyaMukherjee, Lekha Raveendran |
| Compound ID | 3322 |
| Compound Structure | NR |
| Plant Source | Arctostaphylos uva-ursi Sprengel Common Name:Gayuba |
| Source Family | Ericaceae |
| Origin | Spanish Mediterranean Area |
| Plant Part Used | Leaf |
| Extract | Methanol |
| Target Bacteria | Mycobacterium phlei (CECT 3009) |
| Assay / Test Done | NR |
| Positive Control Used (conc.) | Gentamicin (10 µg/ml) |
| Inhibition [%] | NR |
| Activity [MIC] µg/ml | > 1000 µg/ml |
| Activity (In terms of dilution) | NR |
| Activity (Zone of inhibition in mm) | NR |
| Active Compound Identified | NR |
| PubChem ID | NR |
| Ethnomedicinal Information | Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans |
| PubMed ID [Source Literature] | 3325696 |
| Extract Preparation | |
| Chemical Classification [Active Compound] | NR |
| Media / Broth Used [Antimicrobial Assay/Test] | NR |
| Cytotoxicity Assay [AID] | NR |
| Reference(s) | 1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52
|
| Curator | Najiya Beegum |
| Compound ID | 3325 |
| Compound Structure | NR |
| Plant Source | Erica multiflora Common Name:NR |
| Source Family | Ericaceae |
| Origin | Spanish Mediterranean Area |
| Plant Part Used | Aerial |
| Extract | Methanol |
| Target Bacteria | Mycobacterium phlei (CECT 3009) |
| Assay / Test Done | NR |
| Positive Control Used (conc.) | Gentamicin (10 µg/ml) |
| Inhibition [%] | NR |
| Activity [MIC] µg/ml | > 1 x 106 µg/ml |
| Activity (In terms of dilution) | NR |
| Activity (Zone of inhibition in mm) | NR |
| Active Compound Identified | NR |
| PubChem ID | NR |
| Ethnomedicinal Information | Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans |
| PubMed ID [Source Literature] | 3325696 |
| Extract Preparation | |
| Chemical Classification [Active Compound] | NR |
| Media / Broth Used [Antimicrobial Assay/Test] | NR |
| Cytotoxicity Assay [AID] | NR |
| Reference(s) | 1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52
|
| Curator | Vsheeba, Najiya Beegum |