BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 4 Record - 1 of 96 [TOP]

Compound ID	1508
Compound Structure
Plant Source	Colebrookea oppositifolia Smith Common Name:Indian Squirrel Tail (English)
Source Family	Lamiaceae
Origin	India
Plant Part Used	Whole plant
Extract	Ethanol
Target Bacteria	Mycobacterium smegmatis (MTCC 6), Mycobacterium smegmatis (MTCC 995)
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Rifampin (5.0 µg/Disc)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	17.3 ± 1.5 mm and 17 ± 0.0 mm
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Wound, epilepsy
PubMed ID [Source Literature]	21114505
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Shukla C, Bisht GR, Saikia D, Kumar S, Thakur RL.Detection of anti-tuberculosis activity in some folklore plants by radiometric BACTEC assay.Lett Appl Microbiol. 2011 Jan;52(1):33-40 2) http://www.flowersofIndia.net/catalog/slides/Indian%20Squirrel%20Tail.html
Curator

Record - 2 of 96 [TOP]

Compound ID

1554

Compound Structure

Plant Source

Croton kongensis Common Name:

Source Family

Lamiaceae

Origin

China

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Ent - 8, 9 - Seco - 7α, 11β - Diacetoxykaura - 8 (14), 16 - Dien - 9, 15 - Dione

PubChem ID

3010860

Ethnomedicinal Information

Antimalarial activity, tuberculosis, dysmenorrheal treatment

PubMed ID [Source Literature]

12828479, 1511068

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Diterpene, O-Acetyl, Ketone

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against Vero, human epidermoid carcinoma in the mouth (KB) and human breast cancer cells (BC)

Molecular Weight

416.220

Molecular Formula

C₂₄H₃₂O₆

SMILES

O([C@@H]1C[C@H]2[C@@](CCCC2(C)C)(C(=O)[C@@H](OC(=O)C)C[C@@H]2C=C1C(=O)C2=C)C)C(=O)C

XLogP

3.668

PSA

86.740

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Thongtan J, Kittakoop P, Ruangrungsi N, Saenboonrueng J, Thebtaranonth Y.New antimycobacterial and antimalarial 8,9-secokaurane diterpenes from Croton kongensis.J Nat Prod. 2003 Jun;66(6):868-70

2) Hendrix PG, Hoylaerts MF, Nouwen EJ, Van de Voorde A, De Broe ME.Magnetic beads in suspension enable a rapid and sensitive immunodetection of human placental alkaline phosphatase.Eur J Clin Chem Clin Biochem. 1992 Jun;30(6):343-7

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Record - 3 of 96 [TOP]

Compound ID

1555

Compound Structure

Plant Source

Croton kongensis Common Name:

Source Family

Lamiaceae

Origin

China

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Ent - 8, 9 - Seco - 8, 14 - Epoxy - 7α - Hydroxy - 11β - Acetoxy - 16 - Kauren - 9, 15 - Dione

PubChem ID

Ethnomedicinal Information

Antimalarial activity, tuberculosis, dysmenorrheal treatment

PubMed ID [Source Literature]

12828479, 1511068

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tetracyclic, Terpene, Sesquiterpene, Epoxy, Ketone, O-Acetyl, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against Vero, human epidermoid carcinoma in the mouth (KB) and human breast cancer cells (BC)

Molecular Weight

376.189

Molecular Formula

C₂₁H₂₈O₆

SMILES

C1CCC([C@@H]2C1C(=O)[C@H](CC1C3C(C(=O)C1=C)(C(C2)O)O3)OC(=O)C)(C)C

XLogP

1.760

PSA

93.200

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 4 of 96 [TOP]

Compound ID

1556

Compound Structure

Plant Source

Croton kongensis Common Name:

Source Family

Lamiaceae

Origin

China

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Ent - 8, 9 - Seco - 7α - Hydroxy - 11β - Acetoxykaura - 8 (14), 16 - Dien - 9, 15 - Dione

PubChem ID

3010861

Ethnomedicinal Information

Antimalarial activity, tuberculosis, dysmenorrheal treatment

PubMed ID [Source Literature]

12828479, 1511068

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Diterpene, Ketone, Alcohol, O-Acetyl

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against Vero, human epidermoid carcinoma in the mouth (KB) and human breast cancer cells (BC)

Molecular Weight

374.209

Molecular Formula

C₂₂H₃₀O₅

SMILES

O=C1[C@]2([C@@H](C(CCC2)(C)C)C[C@@H](O)C2=C[C@@H](C[C@@H]1OC(=O)C)C(=C)C2=O)C

XLogP

2.928

PSA

80.670

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 5 of 96 [TOP]

Compound ID	1626
Compound Structure
Plant Source	Elsholtzia blanda Benth. Common Name:
Source Family	Lamiaceae
Origin	India
Plant Part Used	Aerial
Extract	Methanol
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Chloramphenicol
Inhibition [%]
Activity [MIC] µg/ml	2000000 µg/ml of dried plant material
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough and cold
PubMed ID [Source Literature]	7564413
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Taylor RS, Manandhar NP, Towers GH.Screening of selected medicinal plants of Nepal for antimicrobial activities.J Ethnopharmacol. 1995 Jun;46(3):153-9
Curator

Record - 6 of 96 [TOP]

Compound ID	1776
Compound Structure
Plant Source	Fuerstia africana T.C.E.Fr. Common Name:
Source Family	Lamiaceae
Origin	Kenya
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2, 1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Malaria, asthma, chest problems
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 7 of 96 [TOP]

Compound ID	1777
Compound Structure
Plant Source	Fuerstia africana T.C.E.Fr. Common Name:
Source Family	Lamiaceae
Origin	Kenya
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium kansasii
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2, 1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Malaria, asthma, chest problems
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 8 of 96 [TOP]

Compound ID	1778
Compound Structure
Plant Source	Fuerstia africana T.C.E.Fr. Common Name:
Source Family	Lamiaceae
Origin	Kenya
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium fortuitum
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2, 1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Malaria, asthma, chest problems
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 9 of 96 [TOP]

Compound ID	1779
Compound Structure
Plant Source	Fuerstia africana T.C.E.Fr. Common Name:
Source Family	Lamiaceae
Origin	Kenya
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2,1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Malaria, asthma, chest problems
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 10 of 96 [TOP]

Compound ID	1984
Compound Structure
Plant Source	Lamium album L. Common Name:White Dead Nettle, Archangel (English)
Source Family	Lamiaceae
Origin	India
Plant Part Used	Whole plant
Extract	Chloroform
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)	Gentamicin (0.01 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	71000 µg/ml of dried plant
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	General infectious diseases, antiseptic, disinfectant
PubMed ID [Source Literature]	3325696
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52
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Record - 11 of 96 [TOP]

Compound ID	1985
Compound Structure
Plant Source	Lamium amplexicaule L Common Name:Goldenseal
Source Family	Lamiaceae
Origin	India
Plant Part Used	Whole plant
Extract	Ethanol (80 %)
Target Bacteria	Mycobacterium intracellulare
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	0.02 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	3 mm, 7 mm
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Laxative, stimulant, diaphoretic, rheumatism, influenza
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Richardson M.D., Peterson J.R., Clark A.M. Bioactivity screenings of plants selected on the basis of folkloric use or presence of lignans in a family. Phytotherapy Research, Volume 6, Issue 5, pages 274–278, September/October 1992
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Record - 12 of 96 [TOP]

Compound ID	2018
Compound Structure
Plant Source	Leonurus sibiricus L. Common Name:
Source Family	Lamiaceae
Origin	Peru
Plant Part Used	Root, stem, leaf
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 13 of 96 [TOP]

Compound ID	2019
Compound Structure
Plant Source	Leonurus sibiricus L. Common Name:Honeyweed (English)
Source Family	Lamiaceae
Origin	India
Plant Part Used	Aerial
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Agar Dilution - Streak Assay
Positive Control Used (conc.)	Streptomycin sulphate (10 µg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Febrifuge, tonic, aphrodisiac, menstrual disorders, post-natal tonic, to contract uterus
PubMed ID [Source Literature]	4561056
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mitscher LA, Leu RP, Bathala MS, Wu WN, Beal JL.Antimicrobial agents from higher plants. I. Introduction, rationale, and methodology.Lloydia. 1972 Jun;35(2):157-66 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
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Record - 14 of 96 [TOP]

Compound ID	2142
Compound Structure
Plant Source	Marrubium vulgare L. Common Name:Horehound (English)
Source Family	Lamiaceae
Origin	India
Plant Part Used	Flower
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, pulmonary troubles
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Anonymous, 1986. The Useful Plants of India. Council of Scientific and Industrial Research, New Delhi, India
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Record - 15 of 96 [TOP]

Compound ID	2143
Compound Structure
Plant Source	Marrubium vulgare L. Common Name:Horehound (English)
Source Family	Lamiaceae
Origin	India
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	1:40 dilution
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, pulmonary troubles
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Anonymous, 1986. The Useful Plants of India. Council of Scientific and Industrial Research, New Delhi, India
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Record - 16 of 96 [TOP]

Compound ID	2159
Compound Structure
Plant Source	Melissa officinalis L. Common Name:Mountain Balm, Sweet or Lemon Balm (English)
Source Family	Lamiaceae
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	1:80 dilution
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculous glands, bronchitis, asthma
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange, J.M., Davey, R.W., 1990. Detection of antituberculous activity in plant extracts. Journal of Applied Bacteriology 68, 587–59 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
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Record - 17 of 96 [TOP]

Compound ID	2160
Compound Structure
Plant Source	Mentha arvensis L. Common Name:Mint (English), Pudina, Putiha (Sanskrit)
Source Family	Lamiaceae
Origin	Malaysia
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sore throat
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Anonymous, 2010g. GaleriMEPIS, buah melaka, Available at: http://agromedia. mardi.gov. my/MEPISgallery/details.phpuimage id=164&sessionid=3c22684dc 245f1b799af3a95716599e0 (accessed 20.04.10). 2) http://www.himalayahealthcare.com/aboutayurveda/cahm.htm
Curator

Record - 18 of 96 [TOP]

Compound ID	2186
Compound Structure
Plant Source	Micromeria biflora Benth. Common Name:Lemon Savory, English Lavender, True Lavender (English)
Source Family	Lamiaceae
Origin	India
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Chloramphenicol
Inhibition [%]
Activity [MIC] µg/ml	2000000 µg/ml of dried plant
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, cold
PubMed ID [Source Literature]	8866730
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Taylor RS, Manandhar NP, Towers GH.Screening of selected medicinal plants of Nepal for antimicrobial activities.J Ethnopharmacol. 1995 Jun;46(3):153-9
Curator

Record - 19 of 96 [TOP]

Compound ID	2245
Compound Structure
Plant Source	Nepeta congesta Fisch. and Mey. var. congesta Common Name:
Source Family	Lamiaceae
Origin	Turkey
Plant Part Used	Aerial
Extract	Ethanol (70 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5
Curator

Record - 20 of 96 [TOP]

Compound ID	2253
Compound Structure
Plant Source	Ocimum americanum L. syn. Ocimum canum Sims. Common Name:Hoary Basil (English), Kaali Tulasi, Vana - Tulasi (Sanskrit)
Source Family	Lamiaceae
Origin	India
Plant Part Used	Leaf
Extract	Volatile oil
Target Bacteria	Mycobacterium tuberculosis B19 - 3 (avian)
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:12, 500 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta, K.C., Viswanathan, R., 1956. Antitubercular substances from plants. A preliminary study. Antibiotics and Chemotherapy 6, 194–195 2) Singh, V., Pandey, R.P., 1980. Medicinal plant lore of the tribals of eastern Rajasthan. Journal of Economic Taxonomy and Botany 1, 137–147
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Record - 21 of 96 [TOP]

Compound ID	2254
Compound Structure
Plant Source	Ocimum basilicum L. Common Name:Sweet Basil, Basil Herb (English), Barbari, Tuvari, Tungi (Sanskrit)
Source Family	Lamiaceae
Origin	India, Malaysia
Plant Part Used	Whole plant
Extract	Chloroform
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)	Gentamicin (0.01 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	22700 µg dried plant/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	General infectious diseases, antiseptic, disinfectant, cough, expectorant
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Recio, M.C., Rios, J.L.,Villar, A., 1989. Antimicrobial activity of selected plants employed in the Spanish Mediterranean area. Part II. Phytotherapy Research 3, 77–80 2) Das, S.N., Janardhanan, K.P., Roy, S.C., 1983. Some observations on the ethnobotany of the tribes of Totopara and adjoining areas in Jalpaiguri district, West Bengal. Journal of Economic Taxonomy and Botany 4, 453–474.
Curator

Record - 22 of 96 [TOP]

Compound ID	2255
Compound Structure
Plant Source	Ocimum basilicum L. Common Name:Sweet Basil, Basil Herb (English), Barbari, Tuvari, Tungi (Sanskrit)
Source Family	Lamiaceae
Origin	India, Malaysia
Plant Part Used	Seed
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	General infectious diseases, antiseptic, disinfectant, cough, expectorant
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Frisbey, A., Roberts, J.M., Jennings, J.C., Gottshall, R.Y., Lucas, E.H., 1953. The occurrence of antibacterial substances in seed plants with special reference to Mycobacterium tuberculosis. Michigan State University Agricultural Applied Science Quaternary Bulletin 35, 392–404
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Record - 23 of 96 [TOP]

Compound ID	2256
Compound Structure
Plant Source	Ocimum basilicum L. Common Name:Sweet Basil, Basil Herb (English), Barbari, Tuvari, Tungi (Sanskrit)
Source Family	Lamiaceae
Origin	India, Malaysia
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	General infectious diseases, antiseptic, disinfectant, cough, expectorant, skin disease, eye disease, fever, wounds
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Zakaria, M., Mohd, M.A., 1994. Traditional Malay Medicinal Plants. Fr Bakti Sdn Bhd, Kuala Lumpur, Malaysia 2) http://parisaramahiti.kar.nic.in/Medicinal_plants_new/med%20plants/p134.html
Curator

Record - 24 of 96 [TOP]

Compound ID	2262
Compound Structure
Plant Source	Ocimum sanctum L. Common Name:Holy Basil, Sacred Basil (English), Tulasi, Surasaa, Surasa, Bhuutaghni, Suravalli, Sulabhaa (Sanskrit)
Source Family	Lamiaceae
Origin	India
Plant Part Used	Leaf
Extract	Ether
Target Bacteria	Mycobacterium tuberculosis B19 - 4 (human)
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)	Streptomycin (1 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	10 µg/ml
Activity (In terms of dilution)	1:1 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, bronchitis, expectorant, cough, bronchitis, leprosy, cough, expectorant
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta, K.C. and R. Viswanathan.A short note on antitubercular substance from Ocimum sanctum.1995, Antibiotics and Chemotherapy 5, 22-23 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 25 of 96 [TOP]

Compound ID	2263
Compound Structure
Plant Source	Ocimum sanctum L. Common Name:Holy Basil, Sacred Basil (English), Tulasi, Surasaa, Surasa, Bhuutaghni, Suravalli, Sulabhaa (Sanskrit)
Source Family	Lamiaceae
Origin	India
Plant Part Used	Leaf
Extract	Ether
Target Bacteria	Mycobacterium tuberculosis B19 - 1 (avian)
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)	Streptomycin (1 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	80 µg/ml
Activity (In terms of dilution)	1:1 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, bronchitis, expectorant, cough, bronchitis, leprosy, cough, expectorant
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta, K.C. and R. Viswanathan.A short note on antitubercular substance from Ocimum sanctum.1995, Antibiotics and Chemotherapy 5, 22-23 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

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