BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 46 [TOP]

Compound ID	1247
Compound Structure
Plant Source	Beilschmiedia tawa Common Name:Tawa
Source Family	Lauraceae
Origin	New Zealand
Plant Part Used	Leaf
Extract
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	96 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sore throat, colds, cough
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 2 of 46 [TOP]

Compound ID	1448
Compound Structure
Plant Source	Cinnamomum camphora (L.) Nees & Eberm Common Name:Camphor tree (English), Karpura, Ghanasaara, Chandra (Sanskrit)
Source Family	Lauraceae
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 and 1:1280 dilutions
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91 2) Sharma, S.K., 1998. Medicinal Plants Used in Ayurveda. National Academy of Ayurveda, Ministry of Health and Family Welfare, Govt. of India, New Delhi, India
Curator

Record - 3 of 46 [TOP]

Compound ID	1449
Compound Structure
Plant Source	Cinnamomum triplinerve (R.& P.) Kostermans Common Name:
Source Family	Lauraceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 4 of 46 [TOP]

Compound ID	1450
Compound Structure
Plant Source	Cinnamomum zeylandicum Breyn. Common Name:Cinnamon, Ceylon Cinnamon (English), Tvak, Daaruchini (Sanskrit)
Source Family	Lauraceae
Origin	Sri Lanka, Sumatra, Eastern Islands, Brazil, Mauritius, India, Jamaica
Plant Part Used	Bark
Extract	Methanol (9.41 %)
Target Bacteria	Mycobacterium avium
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic and used to treat gonorrhoea, asthma, diabetes, diseases of oral cavity, bronchitis, expectorant
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 5 of 46 [TOP]

Compound ID	1451
Compound Structure
Plant Source	Cinnamomum zeylandicum Breyn. Common Name:Cinnamon, Ceylon Cinnamon (English),Tvak, Daaruchini (Sanskrit)
Source Family	Lauraceae
Origin	Sri Lanka, Sumatra, Eastern Islands, Brazil, Mauritius, India, Jamaica, Malaysia
Plant Part Used	Bark
Extract	Methanol (9.41 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic and used to treat gonorrhoea, asthma, diabetes, diseases of oral cavity, bronchitis, expectorant
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 6 of 46 [TOP]

Compound ID	1452
Compound Structure
Plant Source	Cinnamomum zeylanicum Breyn. Common Name:Cinnamon, Ceylon Cinnamon (English),Tvak, Daaruchini (Sanskrit)
Source Family	Lauraceae
Origin	Sri Lanka, Sumatra, Eastern Islands, Brazil, Mauritius, India, Jamaica
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]	100 %
Activity [MIC] µg/ml	1:640 dilution
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic and used to treat gonorrhoea, asthma, diabetes, diseases of oral cavity, bronchitis, expectorant
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 14. Lalit Mohan Basu, Allahabad, India
Curator

Record - 7 of 46 [TOP]

Compound ID	1453
Compound Structure
Plant Source	Cinnamomum zeylanicum Breyn. Common Name:Cinnamon, Ceylon Cinnamon (English),Tvak, Daaruchini (Sanskrit)
Source Family	Lauraceae
Origin	Sri Lanka, Sumatra, Eastern Islands, Brazil, Mauritius, India, Jamaica, Malaysia
Plant Part Used	Stem
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic and used to treat gonorrhoea, asthma, diabetes, diseases of oral cavity, bronchitis, expectorant
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Ong, T., 2008. Rahsia Herba, 2nd ed. Alaf 21 Sdn Bhd, Shah Alam, Selangor, Malaysia 2) http://parisaramahiti.kar.nic.in/Medicinal_plants_new/med%20plants/p52.html
Curator

Record - 8 of 46 [TOP]

Compound ID	1565
Compound Structure
Plant Source	Cryptocarya latifolia Sond. Common Name:Broad - Leaved Quince
Source Family	Lauraceae
Origin	Africa
Plant Part Used	Bark
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	0.001 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Chest ailments, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Lall, N., Meyer, J.J., Wang, Y., Bapela, N.B., van Rensburg, C.E.J., Fourie, B., Franzblau, S.G..Characterization of Intracellular Activity of Antitubercular Constituents the Roots of Euclea natalensis.Pharmaceutical Biology (Formerly International Journal of Pharmacognosy), Volume 43, Number 4, June 2005 , pp. 353-357 2) http://www.growwild.co.za/node/223
Curator

Record - 9 of 46 [TOP]

Compound ID	1566
Compound Structure
Plant Source	Cryptocarya latifolia Sond. Common Name:Broad - Leaved Quince
Source Family	Lauraceae
Origin	Africa
Plant Part Used	Bark
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	0.005 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Chest ailments, Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Lall, N., Meyer, J.J., Wang, Y., Bapela, N.B., van Rensburg, C.E.J., Fourie, B., Franzblau, S.G..Characterization of Intracellular Activity of Antitubercular Constituents the Roots of Euclea natalensis.Pharmaceutical Biology (Formerly International Journal of Pharmacognosy), Volume 43, Number 4, June 2005 , pp. 353-357 2) http://www.growwild.co.za/node/223
Curator

Record - 10 of 46 [TOP]

Compound ID	2237
Compound Structure
Plant Source	Nectandra cuneato-cordata Mez Common Name:
Source Family	Lauraceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 11 of 46 [TOP]

Compound ID	2238
Compound Structure
Plant Source	Nectandra hihua (R. & P.) Rowher Common Name:
Source Family	Lauraceae
Origin	Peru
Plant Part Used	Bark
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	98 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 12 of 46 [TOP]

Compound ID	2239
Compound Structure
Plant Source	Nectandra sp. Common Name:
Source Family	Lauraceae
Origin	Peru
Plant Part Used	Bark, root
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 13 of 46 [TOP]

Compound ID	2265
Compound Structure
Plant Source	Ocotea cernua s.l. (Nees) Mez Common Name:
Source Family	Lauraceae
Origin	Peru
Plant Part Used	Bark, root
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 14 of 46 [TOP]

Compound ID	2312
Compound Structure
Plant Source	Persea americana Mill Common Name:Avocado, Alligator Pear
Source Family	Lauraceae
Origin	Mexico
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	82 - 100 %
Activity [MIC] µg/ml	125 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Digestive, emmenagogue, antibacterial, antioxidant, antifungal, pectoral, stomachic, anthelmintic, antiperiodic, antidiarrheal
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) R. Gomez-Flores, C. Arzate-Quintana, R. Quintanilla-Licea, P. Tamez-Guerra, R. Tamez-Guerra, E. Monreal-Cuevas and C. Rodríguez-Padilla.Antimicrobial Activity of Persea americana Mill (Lauraceae) (Avocado) and Gymnosperma glutinosum (Spreng.) Less (Asteraceae) Leaf Extracts and Active Fractions Against Mycobacterium tuberculosis.American-Eurasian Journal of Scientific Research 3 (2): 188-194, 2008 2) http://www.stuartxchange.org/Abukado.html
Curator

Record - 15 of 46 [TOP]

Compound ID	2313
Compound Structure
Plant Source	Persea americana Mill Common Name:Avocado, Alligator Pear
Source Family	Lauraceae
Origin	Mexico
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	53 - 100 %
Activity [MIC] µg/ml	62.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Digestive, emmenagogue, antibacterial, antioxidant, antifungal, pectoral, stomachic, anthelmintic, antiperiodic, antidiarrheal
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) R. Gomez-Flores, C. Arzate-Quintana, R. Quintanilla-Licea, P. Tamez-Guerra, R. Tamez-Guerra, E. Monreal-Cuevas and C. Rodríguez-Padilla.Antimicrobial Activity of Persea americana Mill (Lauraceae) (Avocado) and Gymnosperma glutinosum (Spreng.) Less (Asteraceae) Leaf Extracts and Active Fractions Against Mycobacterium tuberculosis.American-Eurasian Journal of Scientific Research 3 (2): 188-194, 2008 2) http://www.stuartxchange.org/Abukado.html
Curator

Record - 16 of 46 [TOP]

Compound ID	2314
Compound Structure
Plant Source	Persea americana Mill Common Name:Avocado, Alligator Pear
Source Family	Lauraceae
Origin	Mexico
Plant Part Used	Leaf
Extract	Soxhlet hexane
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	18 - 100 %
Activity [MIC] µg/ml	31.2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Digestive, emmenagogue, antibacterial, antioxidant, antifungal, pectoral, stomachic, anthelmintic, antiperiodic, antidiarrheal
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) R. Gomez-Flores, C. Arzate-Quintana, R. Quintanilla-Licea, P. Tamez-Guerra, R. Tamez-Guerra, E. Monreal-Cuevas and C. Rodríguez-Padilla.Antimicrobial Activity of Persea americana Mill (Lauraceae) (Avocado) and Gymnosperma glutinosum (Spreng.) Less (Asteraceae) Leaf Extracts and Active Fractions Against Mycobacterium tuberculosis.American-Eurasian Journal of Scientific Research 3 (2): 188-194, 2008 2) http://www.stuartxchange.org/Abukado.html
Curator

Record - 17 of 46 [TOP]

Compound ID	2315
Compound Structure
Plant Source	Persea americana Mill Common Name:Avocado, Alligator Pear
Source Family	Lauraceae
Origin	Mexico
Plant Part Used	Leaf
Extract	Soxhlet hexane
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	84 - 100 %
Activity [MIC] µg/ml	31.2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Digestive, emmenagogue, antibacterial, antioxidant, antifungal, pectoral, stomachic, anthelmintic, antiperiodic, antidiarrheal
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) R. Gomez-Flores, C. Arzate-Quintana, R. Quintanilla-Licea, P. Tamez-Guerra, R. Tamez-Guerra, E. Monreal-Cuevas and C. Rodríguez-Padilla.Antimicrobial Activity of Persea americana Mill (Lauraceae) (Avocado) and Gymnosperma glutinosum (Spreng.) Less (Asteraceae) Leaf Extracts and Active Fractions Against Mycobacterium tuberculosis.American-Eurasian Journal of Scientific Research 3 (2): 188-194, 2008 2) http://www.stuartxchange.org/Abukado.html
Curator

Record - 18 of 46 [TOP]

Compound ID	2410
Compound Structure
Plant Source	Pleurotherium parviflorum Ducke Common Name:
Source Family	Lauraceae
Origin	Peru
Plant Part Used	Bark
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml) and Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 19 of 46 [TOP]

Compound ID	3596
Compound Structure
Plant Source	Nectandra hihua (R. & P.) Rowher Common Name:
Source Family	Lauraceae
Origin	Peru
Plant Part Used	Bark
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27294)
Assay / Test Done	Radiometric assay using BACTEC 460 system
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	10 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]	13678239
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator	Rachana, vikramjitmandal

Record - 20 of 46 [TOP]

Compound ID

3984

Compound Structure

Plant Source

Cinnamomum kotoense Common Name:

Source Family

Lauraceae

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

2.8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Lincomolide B

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Butenolides, Fattyacid, Lactone, Ether, Alcohol, Alkene, Alkyne,

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

278.188

Molecular Formula

C₁₇H₂₆O₃

SMILES

C[C@@H]1OC(=O)/C(=C/CCCCCCCCCC#C)/[C@@H]1O

XLogP

5.004

PSA

46.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) Rogoza, L. N.; Salakhutdinov, N. F.; Tolstikov, G. A. Anti-tubercular Activity of Natural Products: Recent Developments. In Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry; Tiwari, V. K. Ed.; Research Signpost: India, 2011; pp 103-120

Curator

Record - 21 of 46 [TOP]

Compound ID

3762

Compound Structure

Plant Source

Laurus novocanariensis Common Name:

Source Family

Lauraceae

Origin

Plant Part Used

Ripe fruit

Extract

Laurel oil

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27294)

Assay / Test Done

Fluorometric Alamar Blue Microassay (FMABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Costunolide

PubChem ID

5281437

Ethnomedicinal Information

Anti-inflammatory, skin infections, anti-rheumatic, vulnerary, blood depurative, stomachic, haemostatic, influenza, apoplexy, constipation

PubMed ID [Source Literature]

17218447

Extract Preparation

Volatile components were removed by hydrodistillation of the oil in a Clevenger - type apparatus to yield the essential oil and an odourless residue containing the lipids and other non - volatile compounds. The residue was partitioned between n - hexane and methanol to separate the lipid fraction from the more polar compounds, including the lactones. The methanolic fraction containing mainly the lactones costunolide (1) and dehydrocostuslactone (2) was further fractioned by column chromatography. 1 and 2 were identified by their mass spectra, and proton and carbon NMR spectra and their purity established as > 95 % by gas chromatography

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Sesquiterpene, Lactone

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

232.146

Molecular Formula

C₁₅H₂₀O₂

SMILES

O1[C@H]2[C@@H](CC/C(=C/CC/C(=C/2)/C)/C)C(=C)C1=O

XLogP

3.308

PSA

26.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Luna-Herrera J, Costa MC, González HG, Rodrigues AI, Castilho PC.Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp.J Antimicrob Chemother. 2007 Mar;59(3):548-52

Curator

Vikramjitmandal

Record - 22 of 46 [TOP]

Compound ID

3763

Compound Structure

Plant Source

Laurus novocanariensis Common Name:

Source Family

Lauraceae

Origin

Plant Part Used

Ripe fruit

Extract

Laurel oil

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35822) (Isoniazid resistant)

Assay / Test Done

Fluorometric Alamar Blue Microassay (FMABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Costunolide

PubChem ID

5281437

Ethnomedicinal Information

Anti-inflammatory, skin infections, anti-rheumatic, vulnerary, blood depurative, stomachic, haemostatic, influenza, apoplexy, constipation

PubMed ID [Source Literature]

17218447

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Sesquiterpene, Lactone

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

232.146

Molecular Formula

C₁₅H₂₀O₂

SMILES

O1[C@H]2[C@@H](CC/C(=C/CC/C(=C/2)/C)/C)C(=C)C1=O

XLogP

3.308

PSA

26.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Luna-Herrera J, Costa MC, González HG, Rodrigues AI, Castilho PC.Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp.J Antimicrob Chemother. 2007 Mar;59(3):548-52

Curator

Vikramjitmandal

Record - 23 of 46 [TOP]

Compound ID

3764

Compound Structure

Plant Source

Laurus novocanariensis Common Name:

Source Family

Lauraceae

Origin

Plant Part Used

Ripe fruit

Extract

Laurel oil

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35838) (Rifampin resistant)

Assay / Test Done

Fluorometric Alamar Blue Microassay (FMABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Costunolide

PubChem ID

5281437

Ethnomedicinal Information

Anti-inflammatory, skin infections, anti-rheumatic, vulnerary, blood depurative, stomachic, haemostatic, influenza, apoplexy, constipation

PubMed ID [Source Literature]

17218447

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Sesquiterpene, Lactone

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

232.146

Molecular Formula

C₁₅H₂₀O₂

SMILES

O1[C@H]2[C@@H](CC/C(=C/CC/C(=C/2)/C)/C)C(=C)C1=O

XLogP

3.308

PSA

26.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Luna-Herrera J, Costa MC, González HG, Rodrigues AI, Castilho PC.Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp.J Antimicrob Chemother. 2007 Mar;59(3):548-52

Curator

Vikramjitmandal

Record - 24 of 46 [TOP]

Compound ID

3765

Compound Structure

Plant Source

Laurus novocanariensis Common Name:

Source Family

Lauraceae

Origin

Plant Part Used

Ripe fruit

Extract

Laurel oil

Target Bacteria

Mycobacterium tuberculosis H37Rv (Streptomycin resistant)

Assay / Test Done

Fluorometric Alamar Blue Microassay (FMABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Costunolide

PubChem ID

5281437

Ethnomedicinal Information

Anti-inflammatory, skin infections, anti-rheumatic, vulnerary, blood depurative, stomachic, haemostatic, influenza, apoplexy, constipation

PubMed ID [Source Literature]

17218447

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Sesquiterpene, Lactone

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

232.146

Molecular Formula

C₁₅H₂₀O₂

SMILES

O1[C@H]2[C@@H](CC/C(=C/CC/C(=C/2)/C)/C)C(=C)C1=O

XLogP

3.308

PSA

26.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Luna-Herrera J, Costa MC, González HG, Rodrigues AI, Castilho PC.Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp.J Antimicrob Chemother. 2007 Mar;59(3):548-52

Curator

Vikramjitmandal

Record - 25 of 46 [TOP]

Compound ID

3766

Compound Structure

Plant Source

Laurus novocanariensis Common Name:

Source Family

Lauraceae

Origin

Plant Part Used

Ripe fruit

Extract

Laurel oil

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 35837) (Ethambutol resistant)

Assay / Test Done

Fluorometric Alamar Blue Microassay (FMABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Costunolide

PubChem ID

5281437

Ethnomedicinal Information

Anti-inflammatory, skin infections, anti-rheumatic, vulnerary, blood depurative, stomachic, haemostatic, influenza, apoplexy, constipation

PubMed ID [Source Literature]

17218447

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Sesquiterpene, Lactone

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

232.146

Molecular Formula

C₁₅H₂₀O₂

SMILES

O1[C@H]2[C@@H](CC/C(=C/CC/C(=C/2)/C)/C)C(=C)C1=O

XLogP

3.308

PSA

26.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Luna-Herrera J, Costa MC, González HG, Rodrigues AI, Castilho PC.Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp.J Antimicrob Chemother. 2007 Mar;59(3):548-52

Curator

Vikramjitmandal

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