BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 11 [TOP]

Compound ID	2179
Compound Structure
Plant Source	Miconia c.f. splendens (Swartz) Griseb Common Name:
Source Family	Melastomataceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 2 of 11 [TOP]

Compound ID	2180
Compound Structure
Plant Source	Miconia cabuku Common Name:
Source Family	Melastomataceae
Origin	Brazil
Plant Part Used	Leaf
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.015 - 0.05 µg/ml)
Inhibition [%]	90 %
Activity [MIC] µg/ml	250 µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pavan FR, Sato DN, Higuchi CT, Santos ACB, Vilegas W, Leite CQE 2009. In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants. Rev Bras Farmacogn 19: 204-206
Curator

Record - 3 of 11 [TOP]

Compound ID	2181
Compound Structure
Plant Source	Miconia cabuku Common Name:
Source Family	Melastomataceae
Origin	Brazil
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.015 - 0.05 µg/ml)
Inhibition [%]	90 %
Activity [MIC] µg/ml	31.2 µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pavan FR, Sato DN, Higuchi CT, Santos ACB, Vilegas W, Leite CQE 2009. In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants. Rev Bras Farmacogn 19: 204-206
Curator

Record - 4 of 11 [TOP]

Compound ID	2182
Compound Structure
Plant Source	Miconia prasina (Sw.) DC Common Name:
Source Family	Melastomataceae
Origin	Puerto Rico
Plant Part Used	Leaf
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Middlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)	Rifampin
Inhibition [%]	47 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	11746852
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42
Curator

Record - 5 of 11 [TOP]

Compound ID	2183
Compound Structure
Plant Source	Miconia racemosa (Aubl.) DC. Common Name:Camasey Felpa
Source Family	Melastomataceae
Origin	Puerto Rico
Plant Part Used	Seed
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Middlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)	Rifampin
Inhibition [%]	41 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	11746852
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42 2) http://plants.usda.gov/java/profile?symbol=MIRA2
Curator

Record - 6 of 11 [TOP]

Compound ID	2184
Compound Structure
Plant Source	Miconia rubiginosa Common Name:
Source Family	Melastomataceae
Origin	Brazil
Plant Part Used	Leaf
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.015 - 0.05 µg/ml)
Inhibition [%]	90 %
Activity [MIC] µg/ml	250 µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pavan FR, Sato DN, Higuchi CT, Santos ACB, Vilegas W, Leite CQE 2009. In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants. Rev Bras Farmacogn 19: 204-206
Curator

Record - 7 of 11 [TOP]

Compound ID	2185
Compound Structure
Plant Source	Miconia rubiginosa Common Name:
Source Family	Melastomataceae
Origin	Brazil
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.015 - 0.05 µg/ml)
Inhibition [%]	90 %
Activity [MIC] µg/ml	31.2 µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pavan FR, Sato DN, Higuchi CT, Santos ACB, Vilegas W, Leite CQE 2009. In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants. Rev Bras Farmacogn 19: 204-206
Curator

Record - 8 of 11 [TOP]

Compound ID	2210
Compound Structure
Plant Source	Mouriri pusa Common Name:
Source Family	Melastomataceae
Origin	Brazil
Plant Part Used	Leaf
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.015 - 0.05 µg/ml)
Inhibition [%]	90 %
Activity [MIC] µg/ml	4000 µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pavan FR, Sato DN, Higuchi CT, Santos ACB, Vilegas W, Leite CQE 2009. In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants. Rev Bras Farmacogn 19: 204-206
Curator

Record - 9 of 11 [TOP]

Compound ID	2211
Compound Structure
Plant Source	Mouriri pusa Common Name:
Source Family	Melastomataceae
Origin	Brazil
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.015 - 0.05 µg/ml)
Inhibition [%]	90 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pavan FR, Sato DN, Higuchi CT, Santos ACB, Vilegas W, Leite CQE 2009. In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants. Rev Bras Farmacogn 19: 204-206
Curator

Record - 10 of 11 [TOP]

Compound ID	2719
Compound Structure
Plant Source	Tetrazygia urbanii Cogn. Common Name:
Source Family	Melastomataceae
Origin	Puerto Rico
Plant Part Used	Leaf
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Middlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)	Rifampin
Inhibition [%]	50 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	11746852
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42
Curator

Record - 11 of 11 [TOP]

Compound ID	2730
Compound Structure
Plant Source	Tococa sp. Common Name:
Source Family	Melastomataceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) radiometric assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

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