BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 34 [TOP]

Compound ID

1218

Compound Structure

Plant Source

Artocarpus lakoocha Roxb.Artocarpus lacucha Buch.-Ham Common Name:Monkey Jack (English), Lakuch, Kshudra Panas, Granthiphala, Pitanaasha (Sanskrit)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 – 0.090 µg/ml) and Kanamycin sulphate (2 – 5 µg/ml))

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Lakoochin A

PubChem ID

3012524

Ethnomedicinal Information

Leprosy, used as folkmedicine for other diseases

PubMed ID [Source Literature]

15043440

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Stilbene, Furanoid, Phenol, Prenylated, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against KB and BC - 1 cell lines

Molecular Weight

406.214

Molecular Formula

C₂₆H₃₀O₄

SMILES

O1c(c2c(CC=C(C)C)c(OC)cc(OC)c2CC=C(C)C)cc2c1cc(O)cc2

XLogP

5.873

PSA

51.830

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Puntumchai A, Kittakoop P, Rajviroongit S, Vimuttipong S, Likhitwitayawuid K, Thebtaranonth Y.Lakoochins A and B, new antimycobacterial stilbene derivatives from Artocarpus lakoocha.J Nat Prod. 2004 Mar;67(3):485-6

2) Pushpangadan P, Atal CK.Ethno-medico-botanical investigations in Kerala I. Some primitive tribals of western ghats and their herbal medicine.J Ethnopharmacol. 1984 Jun;11(1):59-77

Curator

Record - 2 of 34 [TOP]

Compound ID

1219

Compound Structure

Plant Source

Artocarpus lakoocha Roxb.Artocarpus lacucha Buch.-Ham Common Name:Monkey Jack (English), Lakuch, Kshudra Panas, Granthiphala, Pitanaasha (Sanskrit)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 – 0.090 µg/ml) and Kanamycin sulphate (2 – 5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Lakoochin B

PubChem ID

6479925

Ethnomedicinal Information

Leprosy, used as folkmedicine for other diseases

PubMed ID [Source Literature]

15043440

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Stilbene, Furanoid, Phenol, Prenylated

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against KB and BC - 1 cell lines

Molecular Weight

446.246

Molecular Formula

C₂₉H₃₄O₄

SMILES

O1c(c2c(C/C=C(/CCC=C(C)C)C)c(O)cc(O)c2CC=C(C)C)cc2c1cc(O)cc2

XLogP

6.657

PSA

73.830

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 3 of 34 [TOP]

Compound ID	1220
Compound Structure
Plant Source	Artocarpus lakoocha Roxb.Artocarpus lacucha Buch.-Ham Common Name:Monkey Jack (English), Lakuch, Kshudra Panas, Granthiphala, Pitanaasha (Sanskrit)
Source Family	Moraceae
Origin	India
Plant Part Used	Stem
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	1 mg/Disc
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, used as folkmedicine for other diseases
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 4 of 34 [TOP]

Compound ID	1240
Compound Structure
Plant Source	Batocarpus amazonicus (Ducke) Fosberg Common Name:
Source Family	Moraceae
Origin	Peru
Plant Part Used	Bark
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml) and Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 5 of 34 [TOP]

Compound ID	1740
Compound Structure
Plant Source	Ficus carica L. Common Name:Fig, Cultivated Fig, Edible Fig, Wild Fig (English), Anjeer, Anjira, Kakodomar, Phalgu (Sanskrit)
Source Family	Moraceae
Origin	Malaysia
Plant Part Used	Fruit, leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1600 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]	21094237
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mohamad S, Zin NM, Wahab HA, Ibrahim P, Sulaiman SF, Zahariluddin AS, Noor SS.Antituberculosis potential of some ethnobotanically selected Malaysian plants.J Ethnopharmacol. 2011 Feb 16;133(3):1021-6
Curator

Record - 6 of 34 [TOP]

Compound ID	1741
Compound Structure
Plant Source	Ficus citrifolia P. Miller Common Name:Short Leaf Fig, Giant Bearded Fig, Wild Banyan Tree
Source Family	Moraceae
Origin	India, Puerto Rico
Plant Part Used	Leaf
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Middlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)	Rifampin (1 µg/ml)
Inhibition [%]	91 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Therapeutic value for chemotherapy patients, antiplasmodial activity, antimycobacterial activity, asthma, folklore medicine of Puerto Rico
PubMed ID [Source Literature]	11746852
Extract Preparation	Leaves dried and extracted in 95 % ethanol
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 7 of 34 [TOP]

Compound ID	1742
Compound Structure
Plant Source	Ficus maxima Miller Common Name:
Source Family	Moraceae
Origin	Peru
Plant Part Used	Bark
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 8 of 34 [TOP]

Compound ID

1743

Compound Structure

Plant Source

Ficus nervosa Synonym : Ficus angustifolia Roxb Common Name:Wild Banyan Tree (English)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Middlebrook 7 H10 agar method

Positive Control Used (conc.)

Ethambutol (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

16 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

3 - Hydroxyxanthyletin

PubChem ID

46927870

Ethnomedicinal Information

Used in treatment of cough and asthma

PubMed ID [Source Literature]

20658670

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Coumarin, Benzopyran, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

244.074

Molecular Formula

C₁₄H₁₂O₄

SMILES

O1C(C=Cc2c1cc1oc(=O)c(O)cc1c2)(C)C

XLogP

3.940

PSA

46.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Chen LW, Cheng MJ, Peng CF, Chen IS. Secondary Metabolites and Antimycobacterial Activities from the Roots of Ficus nervosa, Chemistry & Biodiversity Volume 7, Issue 7, pages 1814–1821, July 2010

Curator

Record - 9 of 34 [TOP]

Compound ID

1744

Compound Structure

Plant Source

Ficus nervosa Synonym : Ficus angustifolia Roxb Common Name:Wild Banyan Tree (English)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Middlebrook 7 H10 agar method

Positive Control Used (conc.)

Ethambutol (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

220 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Xanthyletin

PubChem ID

65188

Ethnomedicinal Information

Used in treatment of cough and asthma

PubMed ID [Source Literature]

20658670

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Coumarin, Benzopyran

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

228.079

Molecular Formula

C₁₄H₁₂O₃

SMILES

O1C(C=Cc2c1cc1oc(=O)ccc1c2)(C)C

XLogP

3.456

PSA

26.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 10 of 34 [TOP]

Compound ID

1745

Compound Structure

Plant Source

Ficus nervosa Synonym : Ficus angustifolia Roxb Common Name:Wild Banyan Tree (English)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Middlebrook 7 H10 agar method

Positive Control Used (conc.)

Ethambutol (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

150 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Umbelliferone

PubChem ID

5281426

Ethnomedicinal Information

Used in treatment of cough and asthma

PubMed ID [Source Literature]

20658670

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Coumarin, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

162.032

Molecular Formula

C₉H₆O₃

SMILES

O1c2c(ccc(O)c2)ccc1=O

XLogP

2.056

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 11 of 34 [TOP]

Compound ID

1746

Compound Structure

Plant Source

Ficus nervosa Synonym : Ficus angustifolia Roxb Common Name:Wild Banyan Tree (English)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Middlebrook 7 H10 agar method

Positive Control Used (conc.)

Ethambutol (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

>= 110 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Scopoletin

PubChem ID

5280460

Ethnomedicinal Information

Used in treatment of cough and asthma

PubMed ID [Source Literature]

20658670

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Coumarin, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

192.042

Molecular Formula

C₁₀H₈O₄

SMILES

O1c2c(cc(OC)c(O)c2)ccc1=O

XLogP

1.612

PSA

46.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 12 of 34 [TOP]

Compound ID

1747

Compound Structure

Plant Source

Ficus nervosa Synonym : Ficus angustifolia Roxb Common Name:Wild Banyan Tree (English)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Middlebrook 7 H10 agar method

Positive Control Used (conc.)

Ethambutol (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

110 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Carpachromene

PubChem ID

10449654

Ethnomedicinal Information

Used in treatment of cough and asthma

PubMed ID [Source Literature]

20658670

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Flavonoid, Benzopyran, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

336.100

Molecular Formula

C₂₀H₁₆O₅

SMILES

O1C(C=Cc2c1cc1oc(cc(=O)c1c2O)c1ccc(O)cc1)(C)C

XLogP

2.526

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 13 of 34 [TOP]

Compound ID

1748

Compound Structure

Plant Source

Ficus nervosa Synonym : Ficus angustifolia Roxb Common Name:Wild Banyan Tree (English)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Middlebrook 7 H10 agar method

Positive Control Used (conc.)

Ethambutol (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

35 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Genistein

PubChem ID

5280961

Ethnomedicinal Information

Used in treatment of cough and asthma

PubMed ID [Source Literature]

20658670

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Flavonoid, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

270.053

Molecular Formula

C₁₅H₁₀O₅

SMILES

O1c2c(c(=O)c(c3ccc(O)cc3)c1)c(O)cc(O)c2

XLogP

1.225

PSA

77.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 14 of 34 [TOP]

Compound ID

1749

Compound Structure

Plant Source

Ficus nervosa Common Name:Wild Banyan Tree (English)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Middlebrook 7 H10 agar method

Positive Control Used (conc.)

Ethambutol (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

110 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cajanin

PubChem ID

5281706

Ethnomedicinal Information

Used in treatment of cough and asthma

PubMed ID [Source Literature]

20658670

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

300.063

Molecular Formula

C₁₆H₁₂O₆

SMILES

O1c2c(c(=O)c(c3c(O)cc(O)cc3)c1)c(O)cc(OC)c2

XLogP

0.781

PSA

86.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 15 of 34 [TOP]

Compound ID

1750

Compound Structure

Plant Source

Ficus nervosa Synonym : Ficus angustifolia Roxb Common Name:Wild Banyan Tree (English)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Middlebrook 7 H10 agar method

Positive Control Used (conc.)

Ethambutol (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Ergosterol peroxide

PubChem ID

6475145

Ethnomedicinal Information

Used in treatment of cough and asthma

PubMed ID [Source Literature]

20658670

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tetracyclic, Steroid, Peroxide, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

428.329

Molecular Formula

C₂₈H₄₄O₃

SMILES

O1O[C@]23[C@@](C4[C@@]1(C1[C@@]([C@H](CC1)[C@H](C)/C=C/[C@@H](C(C)C)C)(CC4)C)C=C2)(CC[C@H](O)C3)C

XLogP

8.383

PSA

38.690

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 16 of 34 [TOP]

Compound ID

1751

Compound Structure

Plant Source

Ficus nervosa Synonym : Ficus angustifolia Roxb Common Name:Wild Banyan Tree (English)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Middlebrook 7 H10 agar method

Positive Control Used (conc.)

Ethambutol (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

>= 200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(S) - Lasiodiplodin

PubChem ID

Ethnomedicinal Information

Used in treatment of cough and asthma

PubMed ID [Source Literature]

20658670

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Lactone, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

292.167

Molecular Formula

C₁₇H₂₄O₄

SMILES

C1c(cc(c2c1CCCCCCC[C@@H](OC2=O)C)OC)O

XLogP

5.001

PSA

55.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 17 of 34 [TOP]

Compound ID

1752

Compound Structure

Plant Source

Ficus nervosa Synonym : Ficus angustifolia Roxb Common Name:Wild Banyan Tree (English)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Middlebrook 7 H10 agar method

Positive Control Used (conc.)

Ethambutol (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

30 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Prunetin

PubChem ID

5281804

Ethnomedicinal Information

Used in treatment of cough and asthma

PubMed ID [Source Literature]

20658670

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

284.068

Molecular Formula

C₁₆H₁₂O₅

SMILES

O1c2c(c(=O)c(c3ccc(O)cc3)c1)c(O)cc(OC)c2

XLogP

1.744

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 18 of 34 [TOP]

Compound ID

1753

Compound Structure

Plant Source

Ficus nervosa Synonym : Ficus angustifolia Roxb Common Name:Wild Banyan Tree (English)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Middlebrook 7 H10 agar method

Positive Control Used (conc.)

Ethambutol (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

70 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Apigenin

PubChem ID

5280443

Ethnomedicinal Information

Used in treatment of cough and asthma

PubMed ID [Source Literature]

20658670

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

270.053

Molecular Formula

C₁₅H₁₀O₅

SMILES

O1c2c(c(=O)cc1c1ccc(O)cc1)c(O)cc(O)c2

XLogP

1.126

PSA

77.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 19 of 34 [TOP]

Compound ID

1754

Compound Structure

Plant Source

Ficus nervosa Synonym : Ficus angustifolia Roxb Common Name:Wild Banyan Tree (English)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Middlebrook 7 H10 agar method

Positive Control Used (conc.)

Ethambutol (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

<= 2.8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(2S) - Naringenin

PubChem ID

25244584

Ethnomedicinal Information

Used in treatment of cough and asthma

PubMed ID [Source Literature]

20658670

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

271.061

Molecular Formula

C₁₅H₁₁O₅

SMILES

O1[C@@H](CC(=O)c2c1cc(O)cc2[O-])c1ccc(O)cc1

XLogP

0.897

PSA

89.820

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 20 of 34 [TOP]

Compound ID	1755
Compound Structure
Plant Source	Ficus sur Forssk. Common Name:Fig, Bush Fig, Fig of Heaven
Source Family	Moraceae
Origin	Africa
Plant Part Used	Leaf
Extract	Dichloromethane
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	3200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, influenza and colic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://plants.jstor.org/upwta/4_318
Curator

Record - 21 of 34 [TOP]

Compound ID	1756
Compound Structure
Plant Source	Ficus sur Forssk. Common Name:Fig, Bush Fig, Fig of Heaven
Source Family	Moraceae
Origin	Africa
Plant Part Used	Leaf
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	195 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, influenza and colic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://plants.jstor.org/upwta/4_318
Curator

Record - 22 of 34 [TOP]

Compound ID	1757
Compound Structure
Plant Source	Ficus sur Forssk. Common Name:Fig, Bush Fig, Fig of Heaven
Source Family	Moraceae
Origin	Africa
Plant Part Used	Leaf
Extract	Ethanol
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	3120 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, influenza and colic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://plants.jstor.org/upwta/4_318
Curator

Record - 23 of 34 [TOP]

Compound ID	1758
Compound Structure
Plant Source	Ficus sur Forssk. Common Name:Fig, Bush Fig, Fig of Heaven
Source Family	Moraceae
Origin	Africa
Plant Part Used	Bark
Extract	Ethanol
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	3120 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, influenza and colic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://plants.jstor.org/upwta/4_318
Curator

Record - 24 of 34 [TOP]

Compound ID	1759
Compound Structure
Plant Source	Ficus sur Forssk. Common Name:Fig, Bush Fig, Fig of Heaven
Source Family	Moraceae
Origin	Africa
Plant Part Used	Root
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	780 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, influenza and colic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://plants.jstor.org/upwta/4_318
Curator

Record - 25 of 34 [TOP]

Compound ID	1760
Compound Structure
Plant Source	Ficus sur Forssk. Common Name:Fig, Bush Fig, Fig of Heaven
Source Family	Moraceae
Origin	Africa
Plant Part Used	Root
Extract	Ethanol
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	3120 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, influenza and colic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://plants.jstor.org/upwta/4_318
Curator

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