BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 8 [TOP]

Compound ID	2224
Compound Structure
Plant Source	Myristica fatua Houtt. Common Name:Mountain Nutmeg
Source Family	Myristicaceae
Origin	Caledonia
Plant Part Used	Almond
Extract	Dichloromethane
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	96 - well Microplate Dilution Method
Positive Control Used (conc.)	Ethambutol (2.5 µg/ml), Pyrazynamide (20 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Dental protection, tuberculosis
PubMed ID [Source Literature]	15588670
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Billo M, Cabalion P, Waikedre J, Fourneau C, Bouttier S, Hocquemiller R, Fournet A.Screening of some New Caledonian and Vanuatu medicinal plants for antimycobacterial activity.J Ethnopharmacol. 2005 Jan 4;96(1-2):195-200
Curator

Record - 2 of 8 [TOP]

Compound ID	2225
Compound Structure
Plant Source	Myristica fatua Houtt. Common Name:Mountain Nutmeg
Source Family	Myristicaceae
Origin	Caledonia
Plant Part Used	Almond
Extract	Methanol
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	96 - well Microplate Dilution Method
Positive Control Used (conc.)	Ethambutol (2.5 µg/ml), Pyrazynamide (20 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Dental protection, tuberculosis
PubMed ID [Source Literature]	15588670
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Billo M, Cabalion P, Waikedre J, Fourneau C, Bouttier S, Hocquemiller R, Fournet A.Screening of some New Caledonian and Vanuatu medicinal plants for antimycobacterial activity.J Ethnopharmacol. 2005 Jan 4;96(1-2):195-200
Curator

Record - 3 of 8 [TOP]

Compound ID	2226
Compound Structure
Plant Source	Myristica fatua Houtt. Common Name:Mountain nutmeg
Source Family	Myristicaceae
Origin	Caledonia
Plant Part Used	Arille
Extract	Dichloromethane
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	96 - well Microplate Dilution Method
Positive Control Used (conc.)	Ethambutol (2.5 µg/ml), Pyrazynamide (20 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Dental protection, tuberculosis
PubMed ID [Source Literature]	15588670
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Billo M, Cabalion P, Waikedre J, Fourneau C, Bouttier S, Hocquemiller R, Fournet A.Screening of some New Caledonian and Vanuatu medicinal plants for antimycobacterial activity.J Ethnopharmacol. 2005 Jan 4;96(1-2):195-200
Curator

Record - 4 of 8 [TOP]

Compound ID	2227
Compound Structure
Plant Source	Myristica fatua Houtt. Common Name:Mountain Nutmeg
Source Family	Myristicaceae
Origin	Caledonia
Plant Part Used	Arille
Extract	Methanol
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	96 - well Microplate Dilution Method
Positive Control Used (conc.)	Ethambutol (2.5 µg/ml), Pyrazynamide (20 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Dental protection, tuberculosis
PubMed ID [Source Literature]	15588670
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Billo M, Cabalion P, Waikedre J, Fourneau C, Bouttier S, Hocquemiller R, Fournet A.Screening of some New Caledonian and Vanuatu medicinal plants for antimycobacterial activity.J Ethnopharmacol. 2005 Jan 4;96(1-2):195-200
Curator

Record - 5 of 8 [TOP]

Compound ID	2228
Compound Structure
Plant Source	Myristica fragrans Houtt. Common Name:Nutmeg, Mace (English), Jaatiphala, Jaatishasya (Sanskrit)
Source Family	Myristicaceae
Origin	India
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	< 1:20 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 14. Lalit Mohan Basu, Allahabad, India
Curator

Record - 6 of 8 [TOP]

Compound ID	3952
Compound Structure	N/A
Plant Source	Knema gluaca Common Name:NR
Source Family	Myristicaceae
Origin	Evergreen forests in Thailand
Plant Part Used	Fruit, leaf, stem
Extract	NR
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.05 µg/ml) and Kanamycin sulphate (1.25 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	NR
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Acyclic diterpene, glaucaic acid and acyl phenols
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19471882
Extract Preparation	The dried and milled fruits (350 g), leaves (570 g) and stems (700 g) of Knema glauca were separately macerated with n - hexane (5 × 3 l), EtOAc (5 × 3 l) and MeOH (5 × 3 l), respectively
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	Resazurin microplate assay
Reference(s)	1) Rangkaew N, Suttisri R, Moriyasu M, Kawanishi K.A new acyclic diterpene acid and bioactive compounds from Knema glauca.Arch Pharm Res. 2009 May;32(5):685-92. Epub 2009 May 27
Curator	KeyaMukherjee, Swati Gandhi

Record - 7 of 8 [TOP]

Compound ID

4121

Compound Structure

Plant Source

Knema glauca Common Name:

Source Family

Myristicaceae

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Malabaricone A

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkyl, Ketone, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

326.188

Molecular Formula

C₂₁H₂₆O₃

SMILES

Oc1c(C(=O)CCCCCCCCc2ccccc2)c(O)ccc1

XLogP

8.373

PSA

57.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

Record - 8 of 8 [TOP]