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                  Page - 1 of 1                  Record - 1 of 5   [TOP]
Compound ID2098
Compound Structure
Plant SourceMaesa macrophylla (Wall.) A. DC.     Common Name:
Source FamilyMyrsinaceae
OriginIndia
Plant Part UsedBark
ExtractMethanol
Target BacteriaMycobacterium phlei
Assay / Test DoneDisk Diffusion Assay
Positive Control Used (conc.)Chloramphenicol (2 g/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationThe allied species M. indica Wall. for syphilis, anthelmintic, woman disorders, diptheria
PubMed ID [Source Literature]8866730
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Taylor RS, Manandhar NP, Towers GH.Screening of selected medicinal plants of Nepal for antimicrobial activities.J Ethnopharmacol. 1995 Jun;46(3):153-9

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                  Record - 2 of 5   [TOP]
Compound ID2229
Compound Structure
Plant SourceMyrsine coriacea (Sw.) R. Br.     Common Name:Leathery Colicwood
Source FamilyMyrsinaceae
OriginPuerto Rico
Plant Part UsedLeaf, stem
ExtractEthanol (95 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMiddlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)Rifampin
Inhibition [%]43 and 20 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]11746852
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42

2) http://plants.usda.gov/java/profile?symbol=MYCO2

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                  Record - 3 of 5   [TOP]
Compound ID2485
Compound Structure
Plant SourceRapanea melanophloeos (L.) Mez     Common Name:Cape Beech
Source FamilyMyrsinaceae
OriginAfrica
Plant Part UsedBark
ExtractAcetone
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml5000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis symptoms
PubMed ID [Source Literature]10473184
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Lall N, Meyer JJ.In vitro inhibition of drug-resistant and drug-sensitive strains of Mycobacterium tuberculosis by ethnobotanically selected South African plants.J Ethnopharmacol. 1999 Sep;66(3):347-54

2) http://www.plantzAfrica.com/plantqrs/rapanmelan.htm

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                  Record - 4 of 5   [TOP]
Compound ID2653
Compound Structure
Plant SourceStylogine cauliflora (Miq. & C. Mart.) Mez     Common Name:
Source FamilyMyrsinaceae
OriginPeru
Plant Part UsedStem
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis (ATCC 27294)
Assay / Test DoneBACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) radiometric assay
Positive Control Used (conc.)Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]68 %
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]13678239
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35

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                  Record - 5 of 5   [TOP]
Compound ID3991
Compound Structure
DOWNLOAD:
Plant SourceEmbelia Schimperi     Common Name:
Source FamilyMyrsinaceae
Origin
Plant Part Used
Extract
Target BacteriaOne strain of H37Rv, 21 sensitive clinical strains, two clinical isolates resistant to isoniazid, and 13 MDR clinical strains
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml (inactive)
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedProtoprimulagenin A
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Alicyclic, Polycyclic, Terpene,Triterpene, Furanoid, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight458.376
Molecular FormulaC30H50O3
SMILESCC1(C)[C@@H](O)CC[C@@]2(C)C1CC[C@]1(C)C2CC[C@@]23OC[C@@]4([C@@H](C[C@@]12C)O)C3CC(C)(C)CC4
XLogP8.018
PSA49.690
H-bond Donor2
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings6
No. of N0
No. of O3
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) Rogoza, L. N.; Salakhutdinov, N. F.; Tolstikov, G. A. Anti-tubercular Activity of Natural Products: Recent Developments. In Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry; Tiwari, V. K. Ed.; Research Signpost: India, 2011; pp 103-120

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