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                  Page - 1 of 1                  Record - 1 of 5   [TOP]
Compound ID1853
Compound Structure
Plant SourceHeisteria acuminata (Humb. & Bonpl.) Engler     Common Name:
Source FamilyOlacaceae
OriginPeru
Plant Part UsedStem
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis (ATCC 27294)
Assay / Test DoneBACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)Rifampin (2 µg/ml) and Ethambutol (7.5 µg/ml)
Inhibition [%]92 %
Activity [MIC] µg/ml10 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]13678239
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35

Curator

                  Record - 2 of 5   [TOP]
Compound ID2814
Compound StructureN/A
Plant SourceXimenia caffra Sond     Common Name:Sourplum (English), Munhengeni, Mutengeni, Mutsvanzva (Sanskrit)
Source FamilyOlacaceae
OriginKenya
Plant Part UsedRoot
ExtractMethanol
Target BacteriaMycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium chelonae / chelonei, Mycobacterium terrae
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]10% of the inoculum of the five mycobacterial species at 2 mg/ml
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedN/A
PubChem IDNR
Ethnomedicinal InformationDiarrhoea and dysentery, fever, cough, venereal diseases
PubMed ID [Source Literature]9533435
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Fabry W, Okemo PO, Ansorg R.Antibacterial activity of East African medicinal plants.J Ethnopharmacol. 1998 Feb;60(1):79-84

2) http://www.zimbabweflora.co.zw/speciesdata/species.php?species_id=121590

Curator

                  Record - 3 of 5   [TOP]
Compound ID2815
Compound StructureN/A
Plant SourceXimenia caffra Sond. Var. caffra     Common Name:Large Sour Plum
Source FamilyOlacaceae
OriginAfrica
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneTetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)Rifampin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (2.00 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedN/A
PubChem IDNR
Ethnomedicinal InformationDiarrhoea and dysentery, fever, cough, venereal diseases
PubMed ID [Source Literature]20447452
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7

2) http://www.worldagroforestry.org/treedb2/AFTPDFS/Ximenia_caffra.pdf

Curator

                  Record - 4 of 5   [TOP]
Compound ID2816
Compound StructureN/A
Plant SourceXimenia caffra Sond. Var. caffra     Common Name:Large Sour Plum
Source FamilyOlacaceae
OriginAfrica
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium tuberculosis 2 (Clinical isolates resistant to Streptomycin, Rifampin, Ethambutol, Isoniazid)
Assay / Test DoneTetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)Rifampin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (2.00 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedN/A
PubChem IDNR
Ethnomedicinal InformationDiarrhoea and dysentery, fever, cough, venereal diseases
PubMed ID [Source Literature]20447452
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7

2) http://www.worldagroforestry.org/treedb2/AFTPDFS/Ximenia_caffra.pdf

Curator

                  Record - 5 of 5   [TOP]
Compound ID3595
Compound Structure
Plant SourceHeisteria acuminata (Humb. & Bonpl.) Engler     Common Name:
Source FamilyOlacaceae
OriginPeru
Plant Part UsedStem
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test DoneRadiometric assay using BACTEC 460 system
Positive Control Used (conc.)Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]100 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedNR
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]13678239
Extract Preparation
Chemical Classification [Active Compound]NR
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35

CuratorGppreetha, vikramjitmandal


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