BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 17 [TOP]

Compound ID	1002
Compound Structure
Plant Source	Abies nordmanniana (Stev.) Spach ssp. bornmuelleriana (Mattf.) Coode et Cullen Common Name:
Source Family	Pinaceae
Origin	Turkey
Plant Part Used	Leaf
Extract	Ethanol (70 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5
Curator

Record - 2 of 17 [TOP]

Compound ID	1969
Compound Structure
Plant Source	Juniperus pseudosabina Fisch. & Mey. Common Name:Savin (English)
Source Family	Pinaceae
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Incense, random screening
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91 2) Sudhanshu Kumar Jain.Dictionary of Indian Folk Medicine and Ethnobotany:A Reference Manual of Man-Plant Relationships, Ethnic Groups & Ethnobotanists in India.Deep Publications, 1991 - 311 pages
Curator

Record - 3 of 17 [TOP]

Compound ID	2342
Compound Structure
Plant Source	Pinus brutia Ten. Common Name:
Source Family	Pinaceae
Origin	Turkey
Plant Part Used	Oleoresin
Extract	Ethanol (70 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5
Curator

Record - 4 of 17 [TOP]

Compound ID	2343
Compound Structure
Plant Source	Pinus brutia Ten. Common Name:
Source Family	Pinaceae
Origin	Turkey
Plant Part Used	Oleoresin
Extract	Petroleum ether
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5
Curator

Record - 5 of 17 [TOP]

Compound ID	2344
Compound Structure
Plant Source	Pinus brutia Ten. Common Name:
Source Family	Pinaceae
Origin	Turkey
Plant Part Used	Oleoresin
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5
Curator

Record - 6 of 17 [TOP]

Compound ID	2345
Compound Structure
Plant Source	Pinus brutia Ten. Common Name:
Source Family	Pinaceae
Origin	Turkey
Plant Part Used	Oleoresin
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5
Curator

Record - 7 of 17 [TOP]

Compound ID	2346
Compound Structure
Plant Source	Pinus contorta Common Name:Beach Pine
Source Family	Pinaceae
Origin	British Columbia
Plant Part Used
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic and healing properties on wounds, infections, mucous membranes and respiratory complaints
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83 2) http://www.naturalmedicinalherbs.net/herbs/p/pinus-contorta=beach-pine.php
Curator

Record - 8 of 17 [TOP]

Compound ID	2348
Compound Structure
Plant Source	Pinus nigra Arn.ssp. pallasiana (Lamb.) Holmbae Common Name:
Source Family	Pinaceae
Origin	Turkey
Plant Part Used	Leaf
Extract	Ethanol (70 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5
Curator

Record - 9 of 17 [TOP]

Compound ID	2349
Compound Structure
Plant Source	Pinus nigra Arn.ssp. pallasiana (Lamb.) Holmbae Common Name:
Source Family	Pinaceae
Origin	Turkey
Plant Part Used	Cone
Extract	Ethanol (70 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5
Curator

Record - 10 of 17 [TOP]

Compound ID	2350
Compound Structure
Plant Source	Pinus sylvestris L. Common Name:
Source Family	Pinaceae
Origin	Turkey
Plant Part Used	Leaf, Cone
Extract	Ethanol (70 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5
Curator

Record - 11 of 17 [TOP]

Compound ID	3227
Compound Structure	NR
Plant Source	Cedrus deodara (Roxb.) Loud. syn. Cedrus libani Barrel. Common Name:Himalayan Cedar, Deodar (English), Devadaru, Suradruma (Sanskrit)
Source Family	Pinaceae
Origin	India
Plant Part Used	Cone
Extract	Chloroform
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)	Ampicillin (10 µg/disc (14 mm))
Inhibition [%]	NR
Activity [MIC] µg/ml	NR
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	13 mm
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Tuberculous glands, leprosy, pulmonary disorders, bronchitis
PubMed ID [Source Literature]	10548751
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Digrak M, Ilçim A, Hakki Alma M.Antimicrobial activities of several parts of Pinus brutia, Juniperus oxycedrus, Abies cilicia, Cedrus libani and Pinus nigra.Phytother Res. 1999 Nov;13(7):584-7 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator	Vikramjitmandal

Record - 12 of 17 [TOP]

Compound ID	3228
Compound Structure	NR
Plant Source	Cedrus deodara (Roxb.) Loud. syn. Cedrus libani Barrel. Common Name:Himalayan Cedar, Deodar (English), Devadaru, Suradruma (Sanskrit)
Source Family	Pinaceae
Origin	India
Plant Part Used	Cone
Extract	Acetone
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)	Ampicillin (10 µg/disc (14 mm))
Inhibition [%]	NR
Activity [MIC] µg/ml	NR
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	14 mm
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Tuberculous glands, leprosy, pulmonary disorders, bronchitis
PubMed ID [Source Literature]	10548751
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Digrak M, Ilçim A, Hakki Alma M.Antimicrobial activities of several parts of Pinus brutia, Juniperus oxycedrus, Abies cilicia, Cedrus libani and Pinus nigra.Phytother Res. 1999 Nov;13(7):584-7 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator	Vikramjitmandal, Ayurveda

Record - 13 of 17 [TOP]

Compound ID	3229
Compound Structure	NR
Plant Source	Cedrus deodara (Roxb.) Loud. syn. Cedrus libani Barrel. Common Name:Himalayan Cedar, Deodar (English), Devadaru, Suradruma (Sanskrit)
Source Family	Pinaceae
Origin	India
Plant Part Used	Leaf
Extract	Acetone
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)	Ampicillin (10 µg/disc (14 mm))
Inhibition [%]	NR
Activity [MIC] µg/ml	NR
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	12 mm
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Tuberculous glands, leprosy, pulmonary disorders, bronchitis
PubMed ID [Source Literature]	10548751
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Digrak M, Ilçim A, Hakki Alma M.Antimicrobial activities of several parts of Pinus brutia, Juniperus oxycedrus, Abies cilicia, Cedrus libani and Pinus nigra.Phytother Res. 1999 Nov;13(7):584-7 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator	Vikramjitmandal, Ayurveda

Record - 14 of 17 [TOP]

Compound ID	3230
Compound Structure	NR
Plant Source	Cedrus deodara (Roxb.) Loud. syn. Cedrus libani Barrel. Common Name:Himalayan Cedar, Deodar (English), Devadaru, Suradruma (Sanskrit)
Source Family	Pinaceae
Origin	India
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)	Ampicillin (10 µg/disc (14 mm))
Inhibition [%]	NR
Activity [MIC] µg/ml	NR
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	14 mm
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Tuberculous glands, leprosy, pulmonary disorders, bronchitis
PubMed ID [Source Literature]	10548751
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Digrak M, Ilçim A, Hakki Alma M.Antimicrobial activities of several parts of Pinus brutia, Juniperus oxycedrus, Abies cilicia, Cedrus libani and Pinus nigra.Phytother Res. 1999 Nov;13(7):584-7 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator	Vikramjitmandal, Ayurveda

Record - 15 of 17 [TOP]

Compound ID	3472
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:
Source Family	Pinaceae
Origin	India
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid (10 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]	8847882
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) McCutcheon AR, Roberts TE, Gibbons E, Ellis SM, Babiuk LA, Hancock RE, Towers GH.Antiviral screening of British Columbian medicinal plants.J Ethnopharmacol. 1995 Dec 1;49(2):101-10
Curator

Record - 16 of 17 [TOP]

Compound ID	3473
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:
Source Family	Pinaceae
Origin	India
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	13 - 18 mm (at 50 µl)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]	8847882
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) McCutcheon AR, Roberts TE, Gibbons E, Ellis SM, Babiuk LA, Hancock RE, Towers GH.Antiviral screening of British Columbian medicinal plants.J Ethnopharmacol. 1995 Dec 1;49(2):101-10
Curator

Record - 17 of 17 [TOP]

Compound ID	3697
Compound Structure
Plant Source	Pinus brutia Common Name:NR
Source Family	Pinaceae
Origin	Brazil
Plant Part Used	NR
Extract	NR
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	NR
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Traditional use against tuberculosis
PubMed ID [Source Literature]	16302058
Extract Preparation	Water
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Basso LA, da Silva LH, Fett-Neto AG, de Azevedo WF Jr, Moreira Ide S, Palma MS, Calixto JB, Astolfi Filho S, dos Santos RR, Soares MB, Santos DS.The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases--a review.Mem Inst Oswaldo Cruz. 2005 Oct;100(6):475-506. Epub 2005 Nov 8
Curator	Gppreetha

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