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                  Page - 1 of 1                  Record - 1 of 3   [TOP]
Compound ID3591
Compound Structure
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Plant SourceRuprechtia trifolia Griseb     Common Name:
Source FamilyPolynaceae
Origin
Plant Part UsedAerial
ExtractDichloromethane:Methanol
Target BacteriaMycobacterium tuberculosis H37Rv (ATCC 27294)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Rifampin (0.06 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5α, 8α - Epidioxyergosta - 6, 22 - Dien - 3β - Yl Stearate
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]12898418
Extract Preparation
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Steroid, Peroxy, Ester, Stearate
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight694.590
Molecular FormulaC46H78O4
SMILESC12[C@@]3([C@@]4(C=C[C@@]1(C1[C@](CC2)([C@H](CC1)[C@@H](/C=C/[C@@H](C(C)C)C)C)C)OO4)C[C@H](CC3)OC(=O)CCCCCCCCCCCCCCCCC)C
XLogP17.911
PSA44.760
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count22
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) Woldemichael GM, Franzblau SG, Zhang F, Wang Y, Timmermann BN.Inhibitory effect of sterols from Ruprechtia triflora and diterpenes from Calceolaria pinnifolia on the growth of Mycobacterium tuberculosis.Planta Med. 2003 Jul;69(7):628-31

CuratorRachana, vikramjitmandal

                  Record - 2 of 3   [TOP]
Compound ID3593
Compound Structure
DOWNLOAD:
Plant SourceRuprechtia trifolia Griseb     Common Name:
Source FamilyPolynaceae
Origin
Plant Part UsedAerial
ExtractDichloromethane:Methanol
Target BacteriaMycobacterium tuberculosis H37Rv (ATCC 27294)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Rifampin (0.06 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedStigmast - 4 - En - 6β - Ol - 3 - One
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]12898418
Extract Preparation
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Steroid, Ketone, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight428.365
Molecular FormulaC29H48O2
SMILESC1CC(=O)C=C2C(CC3C4CCC(C4(C)CCC3C12C)C(C)CCC(CC)C(C)C)O
XLogP9.980
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count6
No. of Rings4
No. of N0
No. of O2
No. of S0
Reference(s)1) Woldemichael GM, Franzblau SG, Zhang F, Wang Y, Timmermann BN.Inhibitory effect of sterols from Ruprechtia triflora and diterpenes from Calceolaria pinnifolia on the growth of Mycobacterium tuberculosis.Planta Med. 2003 Jul;69(7):628-31

CuratorRachana, vikramjitmandal

                  Record - 3 of 3   [TOP]
Compound ID3964
Compound Structure
DOWNLOAD:
Plant SourceRuprechtia trifolia Griseb     Common Name:
Source FamilyPolynaceae
Origin
Plant Part UsedAerial
ExtractDichloromethane:Methanol
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Rifampin (0.06 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5α,8α-epidioxyergost-6,22-dien-3β-ol
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]12898418
Extract Preparation
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Steroid, Peroxy, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight428.329
Molecular FormulaC28H44O3
SMILESC1C[C@@H](C[C@@]23[C@]1(C1[C@@](C=C2)(OO3)C2[C@](CC1)([C@H](CC2)[C@@H](/C=C/[C@@H](C(C)C)C)C)C)C)O
XLogP8.383
PSA38.690
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings3
No. of N0
No. of O3
No. of S0
Reference(s)1) Woldemichael GM, Franzblau SG, Zhang F, Wang Y, Timmermann BN.Inhibitory effect of sterols from Ruprechtia triflora and diterpenes from Calceolaria pinnifolia on the growth of Mycobacterium tuberculosis.Planta Med. 2003 Jul;69(7):628-31

Curator


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