BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 17 [TOP]

Compound ID	1485
Compound Structure
Plant Source	Clematis cirrhosa L. Common Name:Fern Leaved Clematis, Evergreen Clematis, Evergreen Traveller's Joy, Bower
Source Family	Ranunculaceae
Origin	Turkey
Plant Part Used	Aerial
Extract	Ethanol (70 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5 2) http://www.flowersinisrael.com/Clematiscirrhosa_page.htm
Curator

Record - 2 of 17 [TOP]

Compound ID	1486
Compound Structure
Plant Source	Clematis virginiana Common Name:
Source Family	Ranunculaceae
Origin	USA
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	100 %
Activity [MIC] µg/ml	1:640 dilution
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Fitzpatrick, F.K.Plant substances achieve against mycobacterium tuberculoses.Antibiotics and Chemotherapy, Vol 4, Pages 528-536
Curator

Record - 3 of 17 [TOP]

Compound ID

1533

Compound Structure

Plant Source

Coptis coinensia French Common Name:

Source Family

Ranunculaceae

Origin

China

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium phlei

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

Activity (In terms of dilution)

1:800 dilution

Activity (Zone of inhibition in mm)

Active Compound Identified

Berberine bisulphate

PubChem ID

12457

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

14778141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Isoquinoline, Sulphate

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

336.124

Molecular Formula

C₂₀H₁₉NO₈S

SMILES

S(=O)(=O)(O)[O-].O1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1

XLogP

2.896

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Wang VF.In vitro antibacterial activity of some common Chinese herbs on Mycobacteria tuberculosis.Chin Med J. 1950 May-Jun;68(5-6):169-72

Curator

Record - 4 of 17 [TOP]

Compound ID	1534
Compound Structure
Plant Source	Coptis teeta Wall. Common Name:Gold Thread (English), Mamira, Maamiraa, Tiktamuulaa (Sanskrit)
Source Family	Ranunculaceae
Origin	India
Plant Part Used	Root
Extract	Water
Target Bacteria	Mycobacterium avium
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 5 of 17 [TOP]

Compound ID

1876

Compound Structure

Plant Source

Hydrastis canadensis Common Name:Goldenseal

Source Family

Ranunculaceae

Origin

North America

Plant Part Used

Root

Extract

Ethanol

Target Bacteria

Mycobacterium smegmatis (ATCC 607)

Assay / Test Done

Positive Control Used (conc.)

Streptomycin sulfate (1.56 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Berberine

PubChem ID

2353

Ethnomedicinal Information

Berberine has been demonstrated to reduce the infectivity of bacteria, fungi and protozoa in animals and humans by inhibiting the adherence of microorganisms to the host cells

PubMed ID [Source Literature]

9784149, 4906191

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

336.124

Molecular Formula

C₂₀H₁₈NO₄

SMILES

O1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1

XLogP

2.896

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gentry EJ, Jampani HB, Keshavarz-Shokri A, Morton MD, Velde DV, Telikepalli H, Mitscher LA, Shawar R, Humble D, Baker W.Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2.J Nat Prod. 1998 Oct;61(10):1187-93

2) Amin AH, Subbaiah TV, Abbasi KM.Berberine sulfate: antimicrobial activity, bioassay, and mode of action.Can J Microbiol. 1969 Sep;15(9):1067-76

Curator

Record - 6 of 17 [TOP]

Compound ID

1877

Compound Structure

Plant Source

Hydrastis canadensis Common Name:Goldenseal

Source Family

Ranunculaceae

Origin

North America

Plant Part Used

Root

Extract

Ethanol

Target Bacteria

Mycobacterium bovis (BCG - Bacillus Calmette Guerin)

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Berberine

PubChem ID

2353

Ethnomedicinal Information

Berberine has been demonstrated to reduce the infectivity of bacteria, fungi and protozoa in animals and humans by inhibiting the adherence of microorganisms to the host cells

PubMed ID [Source Literature]

9784149, 4906191

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

336.124

Molecular Formula

C₂₀H₁₈NO₄

SMILES

O1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1

XLogP

2.896

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 7 of 17 [TOP]

Compound ID

1878

Compound Structure

Plant Source

Hydrastis canadensis Common Name:Goldenseal

Source Family

Ranunculaceae

Origin

North America

Plant Part Used

Root

Extract

Ethanol

Target Bacteria

Mycobacterium avium complex

Assay / Test Done

Positive Control Used (conc.)

Streptomycin sulfate (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Berberine

PubChem ID

2353

Ethnomedicinal Information

Berberine has been demonstrated to reduce the infectivity of bacteria, fungi and protozoa in animals and humans by inhibiting the adherence of microorganisms to the host cells

PubMed ID [Source Literature]

9784149, 4906191

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

336.124

Molecular Formula

C₂₀H₁₈NO₄

SMILES

O1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1

XLogP

2.896

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 8 of 17 [TOP]

Compound ID	2249
Compound Structure
Plant Source	Nigella sativum L. Common Name:Black Cumin (English)
Source Family	Ranunculaceae
Origin	India
Plant Part Used	Seed
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 vaule 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Fever
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 9 of 17 [TOP]

Compound ID	2250
Compound Structure
Plant Source	Nigella sativum L. Common Name:Black Cumin (English)
Source Family	Ranunculaceae
Origin	India
Plant Part Used	Seed
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 vaule 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Fever
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 10 of 17 [TOP]

Compound ID	2483
Compound Structure
Plant Source	Ranunculus bulbosus L. Common Name:
Source Family	Ranunculaceae
Origin	India
Plant Part Used	Whole plant
Extract	Cyclohexane and ethyl acetate
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Agar - Well Diffusion Assay
Positive Control Used (conc.)	Streptomycin sulphate (1 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	0.02 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	4 mm, 5 mm, 20 mm (control)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	The allied species R. arvensis L. and R. muricatus L. for asthma, intermittent fever, gout, eczema, tonsilitis, random screening
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) James D. Mcchesney, Robert P. Adams.Co-evaluation of plant extracts as petrochemical substitutes and for biologically active compounds.Economic Botany. 12/1984, 39(1):74-86 2) Sudhanshu Kumar Jain.Dictionary of Indian Folk Medicine and Ethnobotany:A Reference Manual of Man-Plant Relationships, Ethnic Groups & Ethnobotanists in India.Deep Publications, 1991 - 311 pages
Curator

Record - 11 of 17 [TOP]

Compound ID	2484
Compound Structure
Plant Source	Ranunculus cantoniensis DC.syn. Ranunculus pennsylvanicus Hook. f. & Thoms. Common Name:
Source Family	Ranunculaceae
Origin	India
Plant Part Used	Whole plant
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Vesicant, antibacterial
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Frisbey, A., Roberts, J.M., Jennings, J.C., Gottshall, R.Y., Lucas, E.H., 1953. The occurrence of antibacterial substances in seed plants with special reference to Mycobacterium tuberculosis. Michigan State University Agricultural Applied Science Quaternary Bulletin 35, 392–404 2) Anonymous, 1986. The Useful Plants of India. Council of Scientific and Industrial Research, New Delhi, India
Curator

Record - 12 of 17 [TOP]

Compound ID	3125
Compound Structure	NR
Plant Source	Actaea spicata L. syn. Actaea accuminata Wall. ex Royle Common Name:NR
Source Family	Ranunculaceae
Origin	India
Plant Part Used	NR
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	NR
Activity (In terms of dilution)	1:80, 1:320 dilutions
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Asthma
PubMed ID [Source Literature]	2118130
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91
Curator	Najiya-beegum, vikramjitmandal

Record - 13 of 17 [TOP]

Compound ID	3178
Compound Structure	NR
Plant Source	Anemone obtusiloba D. Don Common Name:NR
Source Family	Ranunculaceae
Origin	India
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Chloramphenicol
Inhibition [%]	NR
Activity [MIC] µg/ml	2000000 µg/ml of dried plant
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Cough, cold
PubMed ID [Source Literature]	7564413
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Taylor RS, Manandhar NP, Towers GH.Screening of selected medicinal plants of Nepal for antimicrobial activities.J Ethnopharmacol. 1995 Jun;46(3):153-9
Curator	Najiya-beegum, vikramjitmandal

Record - 14 of 17 [TOP]

Compound ID	3275
Compound Structure
Plant Source	Delphinium brunonianum Royle Common Name:
Source Family	Ranunculaceae
Origin	India
Plant Part Used	Aerial
Extract	Ethanol (80 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Agar Dilution - Streak Assay
Positive Control Used (conc.)
Inhibition [%]	Partial
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory depressant
PubMed ID [Source Literature]	541687
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Al-Shamma A, Mitscher LA.Comprehensive survey of indigenous Iraqi plants for potential economic value. 1. Screening results of 327 species for alkaloids and antimicrobial agents.J Nat Prod. 1979 Nov-Dec;42(6):633-42
Curator

Record - 15 of 17 [TOP]

Compound ID	3276
Compound Structure
Plant Source	Delphinium brunonianum Royle Common Name:
Source Family	Ranunculaceae
Origin	India
Plant Part Used	Root
Extract	Ethanol (80 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Agar Dilution - Streak Assay
Positive Control Used (conc.)
Inhibition [%]	Partial
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory depressant
PubMed ID [Source Literature]	541687
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Al-Shamma A, Mitscher LA.Comprehensive survey of indigenous Iraqi plants for potential economic value. 1. Screening results of 327 species for alkaloids and antimicrobial agents.J Nat Prod. 1979 Nov-Dec;42(6):633-42
Curator	Vsheeba, vikramjitmandal

Record - 16 of 17 [TOP]

Compound ID	3323
Compound Structure	NR
Plant Source	Clematis vitalba Common Name:NR
Source Family	Ranunculaceae
Origin	Spanish Mediterranean Area
Plant Part Used	Aerial
Extract	Chloroform
Target Bacteria	Mycobacterium phlei (CECT 3009)
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)	Gentamicin (10 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans
PubMed ID [Source Literature]	3325696
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]	Mueller - Hinton agar (MHA Difco)
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52
Curator	Farzana-shamsudeen, Najiya Beegum

Record - 17 of 17 [TOP]

Compound ID

3395

Compound Structure

Plant Source

Hydrastis canadensis Common Name:

Source Family

Ranunculaceae

Origin

North America

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Agar Dilution - Streak Assay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Berberine

PubChem ID

2353

Ethnomedicinal Information

PubMed ID [Source Literature]

9828037

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

336.124

Molecular Formula

C₂₀H₁₈NO₄

SMILES

O1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1

XLogP

2.896

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Mitscher LA, Baker W.Tuberculosis: a search for novel therapy starting with natural products.Med Res Rev. 1998 Nov;18(6):363-74

Curator

Wvarsha, keyamukherjee, rachanake

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