| Compound ID | 1081 |
| Compound Structure | |
| Plant Source | Agrimonia eupatoria L. Common Name:Agrimony, Stickle Wort (English) |
| Source Family | Rosaceae |
| Origin | India |
| Plant Part Used | Whole plant |
| Extract | Chloroform |
| Target Bacteria | Mycobacterium phlei |
| Assay / Test Done | Agar - Dilution Test |
| Positive Control Used (conc.) | Gentamicin (0.01 g/ml) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | 100000 µg of dried plant/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | General infectious diseases, antiseptic, disinfectant, cough |
| PubMed ID [Source Literature] | 3325696 |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52
|
| Curator | |
| Compound ID | 1548 |
| Compound Structure | |
| Plant Source | Crataegus pubescens Common Name:Mexican Hawthorn, Manzanilla |
| Source Family | Rosaceae |
| Origin | Mexico |
| Plant Part Used | Aerial |
| Extract | Hexane, methanol |
| Target Bacteria | |
| Assay / Test Done | |
| Positive Control Used (conc.) | |
| Inhibition [%] | |
| Activity [MIC] µg/ml | > 200 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Cough |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Jimenez-Arellanes A, Meckes M, Ramirez R, Torres J, Luna-Herrera J. Activity against multidrug-resistant Mycobacterium tuberculosis in Mexican plants used to treat respiratory diseases. Phytother Res. 2003 Sep;17(8):903-8
|
| Curator | |
| Compound ID | 1642 |
| Compound Structure | |
| Plant Source | Eriobotrya japonica Lindl. Common Name:Loquat, Japanese Medlar (English), Lottaaka (Sanskrit) |
| Source Family | Rosaceae |
| Origin | India |
| Plant Part Used | Leaf |
| Extract | Water |
| Target Bacteria | Mycobacterium tuberculosis |
| Assay / Test Done | |
| Positive Control Used (conc.) | |
| Inhibition [%] | |
| Activity [MIC] µg/ml | |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Expectorant; phthisis, cough, expectorant, asthma |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Frisbey, A., Roberts, J.M., Jennings, J.C., Gottshall, R.Y., Lucas, E.H., 1953. The occurrence of antibacterial substances in seed plants with special reference to Mycobacterium tuberculosis. Michigan State University Agricultural Applied Science Quaternary Bulletin 35, 392–404
|
| Curator | |
| Compound ID | 1773 |
| Compound Structure | |
| Plant Source | Fragaria vesca L. var. brateata(Heller) Davis Common Name:Woodland Strawberry (English) |
| Source Family | Rosaceae |
| Origin | India, British Columbia |
| Plant Part Used | Leaf |
| Extract | Methanol |
| Target Bacteria | Mycobacterium tuberculosis |
| Assay / Test Done | Disk Diffusion Assay |
| Positive Control Used (conc.) | Isoniazid (10 µg/quadrant) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | 50 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Astringent, diuretic, arthritis, gout, liver tonic, boosts your skin internally, digestive upsets, diarrhea, mild laxative action, improving digestion |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83
2) http://www.cmdr.ubc.ca/bobh/rjpdocs/173_1997_IntlJournPharmacog_35_p77.pdf
|
| Curator | |
| Compound ID | 1774 |
| Compound Structure | |
| Plant Source | Fragaria vesca L. var. brateata(Heller) Davis Common Name:Woodland Strawberry (English) |
| Source Family | Rosaceae |
| Origin | India, British Columbia |
| Plant Part Used | Leaf |
| Extract | Methanol |
| Target Bacteria | Mycobacterium phlei |
| Assay / Test Done | Disk Diffusion Assay |
| Positive Control Used (conc.) | Gentamicin (10 µg/Disc) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | 20000 µg/ml of dried plant material |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | 10.1 - 15.0 mm, > 25 mm (control) |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Astringent, diuretic, arthritis, gout, liver tonic, boosts your skin internally, digestive upsets, diarrhea, mild laxative action, improving digestion |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83
|
| Curator | |
| Compound ID | 1807 |
| Compound Structure | |
| Plant Source | Geum macrophyllum Willd.var. macrophyllum Common Name:Large - Leaved Avens |
| Source Family | Rosaceae |
| Origin | British Columbia |
| Plant Part Used | |
| Extract | Methanol |
| Target Bacteria | Mycobacterium tuberculosis |
| Assay / Test Done | Disk Diffusion Assay |
| Positive Control Used (conc.) | Isoniazid |
| Inhibition [%] | 100 % |
| Activity [MIC] µg/ml | 50 µg extract/Disc |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Stomach pain, tuberculosis |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83
|
| Curator | |
| Compound ID | 2436 |
| Compound Structure | |
| Plant Source | Potentilla sericea L. syn. Potentilla pensylvanica L. Common Name: |
| Source Family | Rosaceae |
| Origin | India |
| Plant Part Used | Whole plant |
| Extract | Water |
| Target Bacteria | Mycobacterium tuberculosis |
| Assay / Test Done | |
| Positive Control Used (conc.) | |
| Inhibition [%] | |
| Activity [MIC] µg/ml | |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Astringent |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Frisbey, A., Roberts, J.M., Jennings, J.C., Gottshall, R.Y., Lucas, E.H., 1953. The occurrence of antibacterial substances in seed plants with special reference to Mycobacterium tuberculosis. Michigan State University Agricultural Applied Science Quaternary Bulletin 35, 392–404
2) Anon., 1986. The Useful Plants of India. Council of Scientific and Industrial Research, New Delhi, India
|
| Curator | |
| Compound ID | 2438 |
| Compound Structure | |
| Plant Source | Prinsepia utilis Royale Common Name: |
| Source Family | Rosaceae |
| Origin | India |
| Plant Part Used | Leaf |
| Extract | Methanol |
| Target Bacteria | Mycobacterium phlei |
| Assay / Test Done | Disk Diffusion Assay |
| Positive Control Used (conc.) | Chloramphenicol |
| Inhibition [%] | |
| Activity [MIC] µg/ml | |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | Active at 2 g of dried plant material/ml |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Rheumatism, cuts, wounds, burns |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Taylor RS, Manandhar NP, Towers GH.Screening of selected medicinal plants of Nepal for antimicrobial activities.J Ethnopharmacol. 1995 Jun;46(3):153-9
|
| Curator | |
| Compound ID | 2442 |
| Compound Structure | |
| Plant Source | Prunus africana (Hook. f.) Kalkman Common Name:Red Stinkwood |
| Source Family | Rosaceae |
| Origin | Africa |
| Plant Part Used | Leaf |
| Extract | Ethyl acetate |
| Target Bacteria | Mycobacterium aurum A+ |
| Assay / Test Done | Broth Microdilution Method (BMM) |
| Positive Control Used (conc.) | Ciprofloxacin (1.8 µg/ml) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | 780 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Chest pain, diarrhoea, fever, allergies, stomach ache, prostrate gland disease and kidney disease |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251
2) Pujol, J., 1990. NaturAfrica–the Herbalist Handbook. Jean Pujol Natural Healer's Foundation, Durban
3) http://www.iucnredlist.org/apps/redlist/details/33631/0
|
| Curator | |
| Compound ID | 2443 |
| Compound Structure | |
| Plant Source | Prunus africana (Hook. f.) Kalkman Common Name:Red Stinkwood |
| Source Family | Rosaceae |
| Origin | Africa |
| Plant Part Used | Bark |
| Extract | Dichloromethane |
| Target Bacteria | Mycobacterium aurum A+ |
| Assay / Test Done | Broth Microdilution Method (BMM) |
| Positive Control Used (conc.) | Ciprofloxacin (1.8 µg/ml) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | 6250 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Chest pain, diarrhoea, fever, allergies, stomach ache, prostrate gland disease and kidney disease |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251
2) Pujol, J., 1990. NaturAfrica–the Herbalist Handbook. Jean Pujol Natural Healer's Foundation, Durban
3) http://www.iucnredlist.org/apps/redlist/details/33631/0
|
| Curator | |
| Compound ID | 2444 |
| Compound Structure | |
| Plant Source | Prunus africana (Hook. f.) Kalkman Common Name:Red Stinkwood |
| Source Family | Rosaceae |
| Origin | Africa |
| Plant Part Used | Bark |
| Extract | Ethyl acetate |
| Target Bacteria | Mycobacterium aurum A+ |
| Assay / Test Done | Broth Microdilution Method (BMM) |
| Positive Control Used (conc.) | Ciprofloxacin (1.8 µg/ml) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | 1560 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Chest pain, diarrhoea, fever, allergies, stomach ache, prostrate gland disease and kidney disease |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251
2) Pujol, J., 1990. NaturAfrica–the Herbalist Handbook. Jean Pujol Natural Healer's Foundation, Durban
3) http://www.iucnredlist.org/apps/redlist/details/33631/0
|
| Curator | |
| Compound ID | 2445 |
| Compound Structure | |
| Plant Source | Prunus domesticata L. syn. Prunus communis Huds. Common Name:European Plum (English) |
| Source Family | Rosaceae |
| Origin | India |
| Plant Part Used | Leaf |
| Extract | Water |
| Target Bacteria | Mycobacterium tuberculosis |
| Assay / Test Done | Broth Dilution Assay |
| Positive Control Used (conc.) | |
| Inhibition [%] | |
| Activity [MIC] µg/ml | |
| Activity (In terms of dilution) | < 1:40 dilution |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Digestive, aperient, astringent, laxative, leucorrhoea, irregular menstruation |
| PubMed ID [Source Literature] | 17276637 |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 14. Lalit Mohan Basu, Allahabad, India
|
| Curator | |
| Compound ID | 2446 |
| Compound Structure |  |
| Plant Source | Prunus mume Common Name:Japanese Apricot, Japanese Plum, Chinese Plum |
| Source Family | Rosaceae |
| Origin | China |
| Plant Part Used | Berry |
| Extract | |
| Target Bacteria | Mycobacterium tuberculosis 607 |
| Assay / Test Done | Paper Disk Method |
| Positive Control Used (conc.) | |
| Inhibition [%] | |
| Activity [MIC] µg/ml | NR |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | 7.1 mm |
| Active Compound Identified | Citric acid |
| PubChem ID | NR |
| Ethnomedicinal Information | Used as traditional Chinese medicine in stopping ulcers and promoting a strong digestive system and heart |
| PubMed ID [Source Literature] | 4978259, 4978260 |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | Aliphatic, Acid, Alcohol |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Molecular Weight | 192.027 |
| Molecular Formula | C6H8O7 |
| SMILES | OC(CC(=O)O)(CC(=O)O)C(=O)O |
| XLogP | -2.247 |
| PSA | 132.130 |
| H-bond Donor | 4 |
| H-bond Acceptor | 7 |
| No. of Rotatable Bond Count | 5 |
| No. of Rings | 0 |
| No. of N | 0 |
| No. of O | 7 |
| No. of S | 0 |
| Reference(s) | 1) Ma TS, Roper R.Microchemical investigation of medicinal plants. I. The antitubercular principle in Prunus mume and Schizandra chinensis.Mikrochim Acta. 1968;(1):167-81
2) Roper R, Ma TS.Microchemical investigation of medicinal plants. II. The antitubercular activity of some plant acids and their hydrazides.Mikrochim Acta. 1968;(1):212-8
3) Kariyone T, Kimura Y. 196 Japanese and Chinese Medicinal Plants (in Japanese), 3rd edn. Hirokawa: Tokyo, 250-290 AND Li Shih-Chen. 1930. Compendium of Materia Medica (in Chinese), 1st edn, Naking, 1593; revised a
|
| Curator | |
| Compound ID | 2447 |
| Compound Structure | |
| Plant Source | Prunus persica Batsch Common Name:Peach (English), Aaluka, Aaruka, Aru, Pichuka (Sanskrit) |
| Source Family | Rosaceae |
| Origin | India |
| Plant Part Used | Stem |
| Extract | Water |
| Target Bacteria | Mycobacterium tuberculosis |
| Assay / Test Done | |
| Positive Control Used (conc.) | |
| Inhibition [%] | |
| Activity [MIC] µg/ml | |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Cough, bronchitis, expectorant |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Frisbey, A., Roberts, J.M., Jennings, J.C., Gottshall, R.Y., Lucas, E.H., 1953. The occurrence of antibacterial substances in seed plants with special reference to Mycobacterium tuberculosis. Michigan State University Agricultural Applied Science Quaternary Bulletin 35, 392–404
2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
|
| Curator | |
| Compound ID | 2475 |
| Compound Structure | |
| Plant Source | Pyrus malus L. Common Name:Cultivated Apple (English), Sinchitikaa (Sanskrit) |
| Source Family | Rosaceae |
| Origin | India |
| Plant Part Used | Leaf, peel |
| Extract | Water |
| Target Bacteria | Mycobacterium tuberculosis |
| Assay / Test Done | Broth Dilution Assay |
| Positive Control Used (conc.) | |
| Inhibition [%] | |
| Activity [MIC] µg/ml | |
| Activity (In terms of dilution) | < 1:20 dilution |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Intermittent, remittent and bilious fevers, inflammed eyes, anthelmintic, refrigerant, hypnotic |
| PubMed ID [Source Literature] | 17276637 |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 14. Lalit Mohan Basu, Allahabad, India
|
| Curator | |
| Compound ID | 2500 |
| Compound Structure | |
| Plant Source | Rosa canina Linn. Common Name:Dog Rose |
| Source Family | Rosaceae |
| Origin | Europe, North Africa and parts of Asia |
| Plant Part Used | Hips |
| Extract | Methanol (37.28 %) |
| Target Bacteria | Mycobacterium aurum |
| Assay / Test Done | Broth Microdilution Method (BMM) |
| Positive Control Used (conc.) | Streptomycin (IC50 value 1.14) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | > 500 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Consumption, cough and spitting of blood |
| PubMed ID [Source Literature] | 11744296 |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
|
| Curator | |
| Compound ID | 2501 |
| Compound Structure | |
| Plant Source | Rosa canina Linn. Common Name:Dog Rose |
| Source Family | Rosaceae |
| Origin | Europe, North Africa and parts of Asia |
| Plant Part Used | Hips |
| Extract | Methanol (37.28 %) |
| Target Bacteria | Mycobacterium smegmatis |
| Assay / Test Done | Broth Microdilution Method (BMM) |
| Positive Control Used (conc.) | Streptomycin (IC50 value 0.17) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | > 500 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Consumption, cough and spitting of blood |
| PubMed ID [Source Literature] | 11744296 |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
|
| Curator | |
| Compound ID | 2502 |
| Compound Structure | |
| Plant Source | Rosa centifolia Common Name:Cabbage Rose |
| Source Family | Rosaceae |
| Origin | Mexico |
| Plant Part Used | Petal |
| Extract | Hexane, chloroform, methanol, water |
| Target Bacteria | Mycobacterium tuberculosis H37Rv (Sensitive) |
| Assay / Test Done | Microplate Alamar Blue Assay (MABA) |
| Positive Control Used (conc.) | |
| Inhibition [%] | |
| Activity [MIC] µg/ml | > 200 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Antiseptic, tuberculosis |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
2) http://plants.usda.gov/java/profile?symbol=ROCE
|
| Curator | |
| Compound ID | 2503 |
| Compound Structure | |
| Plant Source | Rosa multiflora Thunb. Common Name:Rakta - Taruni (Sanskrit) |
| Source Family | Rosaceae |
| Origin | India |
| Plant Part Used | Flower |
| Extract | Water |
| Target Bacteria | Mycobacterium tuberculosis |
| Assay / Test Done | |
| Positive Control Used (conc.) | |
| Inhibition [%] | |
| Activity [MIC] µg/ml | |
| Activity (In terms of dilution) | 1:40 dilution |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Cathartic, foul ulcers, sprains, wounds, injuries |
| PubMed ID [Source Literature] | 17276637 |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
|
| Curator | |
| Compound ID | 2504 |
| Compound Structure | |
| Plant Source | Rosa nutkana Presl var. nutkana Common Name:Nootka Rose |
| Source Family | Rosaceae |
| Origin | British Columbia |
| Plant Part Used | |
| Extract | Methanol |
| Target Bacteria | Mycobacterium tuberculosis, Mycobacterium avium |
| Assay / Test Done | Disk Diffusion Assay |
| Positive Control Used (conc.) | Isoniazid |
| Inhibition [%] | |
| Activity [MIC] µg/ml | 50 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Sore eyes, treatment of sore throats |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83
2) http://www.forthall.net/LC%20Flowers/nootka_rose.htm
|
| Curator | |
| Compound ID | 2507 |
| Compound Structure | |
| Plant Source | Rubus cissoides Common Name:Bush Lawyer |
| Source Family | Rosaceae |
| Origin | New Zealand |
| Plant Part Used | Leaf |
| Extract | |
| Target Bacteria | Mycobacterium smegmatis |
| Assay / Test Done | 96 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract |
| Positive Control Used (conc.) | Rifampin (100 µM), Streptomycin (100 µM) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Chest congestion, coughs and sore throats |
| PubMed ID [Source Literature] | 20537175 |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
|
| Curator | |
| Compound ID | 2508 |
| Compound Structure | |
| Plant Source | Rubus fruticosus L. Common Name:European Blackberry (English) |
| Source Family | Rosaceae |
| Origin | India |
| Plant Part Used | Aerial |
| Extract | Methanol |
| Target Bacteria | Mycobacterium phlei |
| Assay / Test Done | Agar - Dilution Test |
| Positive Control Used (conc.) | Gentamicin (0.01 mg/ml) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | 1000 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Wound healing, antiseptic and disinfectant qualities, whooping cough |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52
|
| Curator | |
| Compound ID | 2558 |
| Compound Structure | |
| Plant Source | Sanguisorba officinalis L. Common Name: |
| Source Family | Rosaceae |
| Origin | China |
| Plant Part Used | |
| Extract | Alcohol |
| Target Bacteria | Mycobacterium tuberculosis |
| Assay / Test Done | |
| Positive Control Used (conc.) | |
| Inhibition [%] | 100 % |
| Activity [MIC] µg/ml | |
| Activity (In terms of dilution) | 1:50 dilution |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Treatment for bleeding, used to stop bloody dysentery, nosebleeds, treat burns and insect bites |
| PubMed ID [Source Literature] | 14778141 |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Wang VF.In vitro antibacterial activity of some common Chinese herbs on Mycobacteria tuberculosis.Chin Med J. 1950 May-Jun;68(5-6):169-72
|
| Curator | |
| Compound ID | 3346 |
| Compound Structure | NR |
| Plant Source | Rubus fruticosus Common Name:NR |
| Source Family | Rosaceae |
| Origin | Spanish Mediterranean Area |
| Plant Part Used | Aerial |
| Extract | Methanol |
| Target Bacteria | Mycobacterium phlei (CECT 3009) |
| Assay / Test Done | NR |
| Positive Control Used (conc.) | Gentamicin (10 µg/ml) |
| Inhibition [%] | NR |
| Activity [MIC] µg/ml | 1 x 106 µg/ml |
| Activity (In terms of dilution) | NR |
| Activity (Zone of inhibition in mm) | NR |
| Active Compound Identified | NR |
| PubChem ID | NR |
| Ethnomedicinal Information | Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans |
| PubMed ID [Source Literature] | 3325696 |
| Extract Preparation | |
| Chemical Classification [Active Compound] | NR |
| Media / Broth Used [Antimicrobial Assay/Test] | NR |
| Cytotoxicity Assay [AID] | NR |
| Reference(s) | 1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52
|
| Curator | KeyaMukherjee, Najiya Beegum |
| Compound ID | 3347 |
| Compound Structure | |
| Plant Source | Rubus fruticosus Common Name:NR |
| Source Family | Rosaceae |
| Origin | Spanish Mediterranean Area |
| Plant Part Used | Aerial |
| Extract | Methanol |
| Target Bacteria | Mycobacterium phlei (CECT 3009) |
| Assay / Test Done | NR |
| Positive Control Used (conc.) | Gentamicin (10 µg/ml) |
| Inhibition [%] | NR |
| Activity [MIC] µg/ml | 1000 µg/ml |
| Activity (In terms of dilution) | NR |
| Activity (Zone of inhibition in mm) | NR |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans |
| PubMed ID [Source Literature] | 3325696 |
| Extract Preparation | |
| Chemical Classification [Active Compound] | |
| Media / Broth Used [Antimicrobial Assay/Test] | NR |
| Cytotoxicity Assay [AID] | NR |
| Reference(s) | 1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52
|
| Curator | KeyaMukherjee, Najiya Beegum |
