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                  Page - 1 of 1                  Record - 1 of 6   [TOP]
Compound ID1723
Compound Structure
Plant SourceExocarpus bidwilli     Common Name:
Source FamilySantalaceae
OriginNew Zealand
Plant Part UsedLeaf, seed
Extract
Target BacteriaMycobacterium smegmatis
Assay / Test Done96 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]20537175
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25

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                  Record - 2 of 6   [TOP]
Compound ID2578
Compound Structure
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Plant SourceScleropyrum pentandrum     Common Name:
Source FamilySantalaceae
OriginIndia, Malaysia, Philippines, Singapore, Sri Lanka
Plant Part UsedTwig
ExtractHexane
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Rifampin (0.004 µg/ml), Isoniazid (0.06 µg/ml), Kanamycin sulphate (2.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedScleropyric acid
PubChem ID   11594149
Ethnomedicinal InformationMalaria, tuberculosis
PubMed ID [Source Literature]16204994
Extract PreparationThe pulverized, dry twigs (1.06 kg) were extracted successively with n - Hexane, CHCl3 and MeOH in a soxhlet extraction apparatus to yield the hexane (7.12 g), CHCl3 (3.50 g), and MeOH (12.42 g) extracts, respectively
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Fatty acid
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight264.209
Molecular FormulaC17H28O2
SMILESOC(=O)CCCCCCCCCCC#CCCC=C
XLogP6.563
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count12
No. of Rings0
No. of N0
No. of O2
No. of S0
Reference(s)1) Suksamrarn A, Buaprom M, Udtip S, Nuntawong N, Haritakun R, Kanokmedhakul S.Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum.Chem Pharm Bull (Tokyo). 2005 Oct;53(10):1327-9

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                  Record - 3 of 6   [TOP]
Compound ID2720
Compound Structure
Plant SourceThesium hystrix A.W. Hill.     Common Name:
Source FamilySantalaceae
OriginAfrica
Plant Part UsedRoot
Extract
Target Bacteria
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationCoughs, tuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Watt, John Mitchell, and Maria Gerdina Breyer-Brandwijk. 1962. The medicinal and poisonous plants of southern and eastern Africa; being an account of their medicinal and other uses, chemical composition, pharmacological effects and toxicology in man and animal. Edinburgh: Livingstone (2nd Edition)

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                  Record - 4 of 6   [TOP]
Compound ID4101
Compound Structure
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Plant SourceExocarpus latifolius     Common Name:
Source FamilySantalaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml20 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedExocarpic acid
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Fatty acid
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight274.193
Molecular FormulaC18H26O2
SMILESC(CCCCCCC(=O)O)C#CC#C/C=C/CCCC
XLogP6.906
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count10
No. of Rings0
No. of N0
No. of O2
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

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                  Record - 5 of 6   [TOP]
Compound ID4102
Compound Structure
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Plant SourceExocarpus latifolius     Common Name:
Source FamilySantalaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedEJMC220
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Fatty acid, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight290.188
Molecular FormulaC18H26O3
SMILESOC(CCCCCCC(=O)O)C#CC#C/C=C/CCCC
XLogP5.509
PSA57.530
H-bond Donor2
H-bond Acceptor3
No. of Rotatable Bond Count10
No. of Rings0
No. of N0
No. of O3
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

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                  Record - 6 of 6   [TOP]
Compound ID4103
Compound Structure
DOWNLOAD:
Plant SourceExocarpus latifolius     Common Name:
Source FamilySantalaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedEJMC221
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aliphatic, Alkyne, Fatty acid, Monoglyceride
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight348.230
Molecular FormulaC21H32O4
SMILESCCCC/C=C/C#CC#CCCCCCCCC(=O)OCC(O)CO
XLogP5.846
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count14
No. of Rings0
No. of N0
No. of O4
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

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