BioPhytMol: A database of Phytomolecules against Mycobacteria

| Home |

Simple Search

Query Builder

Structure Search

Browse |

Similarity

One to One

One to Many

Data Visualization |

Submission |

Page - 1 of 1 Record - 1 of 15 [TOP]

Compound ID	1605
Compound Structure
Plant Source	Digitalis ferruginea L. ssp. schischkinii (Ivan) Werner Common Name:Rusty Foxglove
Source Family	Scrophulariaceae
Origin	Turkey
Plant Part Used	Aerial
Extract	Ethanol (70 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5 2) http://luirig.altervista.org/schedeit/ae/digitalis_ferruginea.htm
Curator

Record - 2 of 15 [TOP]

Compound ID

2043

Compound Structure

Plant Source

Limnophila geoffrayi Common Name:Geoffrey's Marshweed

Source Family

Scrophulariaceae

Origin

Thailand

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampicin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin Sulfate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Nevadensin

PubChem ID

160921

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

14609129

Extract Preparation

The pulverized, dried aerial plant material (615 g) was extracted successively with n-hexane, CHCl₃ and MeOH in a Soxhlet apparatus to give the hexane (7.52 g), CHCl₃ (7.79 g) and MeOH (50.10 g) extracts, respectively

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

344.090

Molecular Formula

C₁₈H₁₆O₇

SMILES

O1c2c(c(O)c(OC)c(O)c2OC)c(=O)cc1c1ccc(OC)cc1

XLogP

0.757

PSA

85.220

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Suksamrarn A, Poomsing P, Aroonrerk N, Punjanon T, Suksamrarn S, Kongkun S.Antimycobacterial and antioxidant flavones from Limnophila geoffrayi.Arch Pharm Res. 2003 Oct;26(10):816-20

2) http://www.oswaldasia.org/species/l/limge/limge_en.html

Curator

Record - 3 of 15 [TOP]

Compound ID

2044

Compound Structure

Plant Source

Limnophila geoffrayi Common Name:Geoffrey's Marshweed

Source Family

Scrophulariaceae

Origin

Thailand

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampicin (0.003 - 0.0047 µg/ml), Isoniazid (0.025 - 0.05 µg/ml), Kanamycin Sulfate (1.25 - 2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Isothymusin

PubChem ID

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

14609129

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

330.074

Molecular Formula

C₁₇H₁₄O₇

SMILES

C1(c(c(c(c2c1oc(cc2=O)c1ccc(cc1)O)O)OC)OC)O

XLogP

0.595

PSA

96.220

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 4 of 15 [TOP]

Compound ID	2219
Compound Structure
Plant Source	Myoporum laetum Common Name:Ngaio
Source Family	Scrophulariaceae
Origin	New Zealand
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	96 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]	90 %
Activity [MIC] µg/ml	630 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bruises and infected wounds
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 5 of 15 [TOP]

Compound ID	2220
Compound Structure
Plant Source	Myoporum laetum Common Name:Ngaio
Source Family	Scrophulariaceae
Origin	New Zealand
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium bovis
Assay / Test Done	97 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]
Activity [MIC] µg/ml	> 10000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bruises and infected wounds
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 6 of 15 [TOP]

Compound ID	2221
Compound Structure
Plant Source	Myoporum laetum Common Name:Ngaio
Source Family	Scrophulariaceae
Origin	New Zealand
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	98 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]
Activity [MIC] µg/ml	> 10000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bruises and infected wounds
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 7 of 15 [TOP]

Compound ID	2776
Compound Structure
Plant Source	Verbascum thapsus L. Common Name:Cow's Lungwort, Common Mullein, Aaron's Rod (English), Ban Tambaaku, Gidar Tambaaku, Phullaa (Sanskrit)
Source Family	Scrophulariaceae
Origin	Britain, Europe, Temperate Asia, North America, India
Plant Part Used	Flower, leaf
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, bronchitis, phthisis, cough, consumption, asthma, pulmonary diseases
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 8 of 15 [TOP]

Compound ID	2777
Compound Structure
Plant Source	Verbascum thapsus L. Common Name:Cow's Lungwort, Common Mullein, Aaron's Rod (English), Ban Tambaaku, Gidar Tambaaku, Phullaa (Sanskrit)
Source Family	Scrophulariaceae
Origin	Britain, Europe, Temperate Asia, North America, India
Plant Part Used	Flower, leaf
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, bronchitis, phthisis, cough, consumption, asthma, pulmonary diseases
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 9 of 15 [TOP]

Compound ID	2778
Compound Structure
Plant Source	Verbascum thapsus L. Common Name:Cow's Lungwort, Common Mullein, Aaron's Rod (English), Ban Tambaaku, Gidar Tambaaku, Phullaa (Sanskrit)
Source Family	Scrophulariaceae
Origin	Britain, Europe, Temperate Asia, North America, India
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]	< 1:40 dilution
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, bronchitis, phthisis, cough, consumption, asthma, pulmonary diseases
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Sharma, P.K., Dhyani, S.K., Shanker,V., 1979. Some useful and medicinal plants of the district Dehradun and Siwalik. Journal of Science Research in Plant Medicine 1, 17–43.
Curator

Record - 10 of 15 [TOP]

Compound ID	2779
Compound Structure
Plant Source	Verbascum thapsus L. Common Name:Cow's Lungwort, Common Mullein, Aaron's Rod (English), Ban Tambaaku, Gidar Tambaaku, Phullaa (Sanskrit)
Source Family	Scrophulariaceae
Origin	Britain, Europe, Temperate Asia, North America, India
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Gentamicin (10 µg/Disc)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	8.0 mm, 10.0 mm at 2 g/ml, control (> 25 mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, bronchitis, phthisis, cough, consumption, asthma, pulmonary diseases
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) McCutcheon AR, Ellis SM, Hancock RE, Towers GH.Antibiotic screening of medicinal plants of the British Columbian native peoples.J Ethnopharmacol. 1992 Oct;37(3):213-23 2) Sharma, P.K., Dhyani, S.K., Shanker,V., 1979. Some useful and medicinal plants of the district Dehradun and Siwalik. Journal of Science Research in Plant Medicine 1, 17–43.
Curator

Record - 11 of 15 [TOP]

Compound ID	3184
Compound Structure	NR
Plant Source	Antirrhinum Majus L. Common Name:Snapdragon (English)
Source Family	Scrophulariaceae
Origin	India
Plant Part Used	Calyx
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	NR
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	NR
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Cardiotonic, sedative, ulcers, hypotensive, tumours
PubMed ID [Source Literature]	10925394
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Newton SM, Lau C, Wright CW.A review of antimycobacterial natural products.Phytother Res. 2000 Aug;14(5):303-22 2) Anonymous, 1986. The Useful Plants of India. Council of Scientific and Industrial Research, New Delhi, India
Curator	Reshmi, vikramjitmandal

Record - 12 of 15 [TOP]

Compound ID	3185
Compound Structure	NR
Plant Source	Antirrhinum Majus L. Common Name:Snapdragon (English)
Source Family	Scrophulariaceae
Origin	India
Plant Part Used	Calyx
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	NR
Activity (In terms of dilution)	< 1:80 dilution
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Cardiotonic, sedative, ulcers, hypotensive, tumours
PubMed ID [Source Literature]	17276637
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Anonymous, 1986. The Useful Plants of India. Council of Scientific and Industrial Research, New Delhi, India
Curator	Reshmi, vikramjitmandal

Record - 13 of 15 [TOP]

Compound ID

3588

Compound Structure

Plant Source

Caleolaria pinnifolia Cav. Common Name:NR

Source Family

Scrophulariaceae

Origin

Plant Part Used

Aerial

Extract

Dichloromethane:Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27 294)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.06 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

19 - Malonyloxydehydroabietinol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

12898418

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Diterpene, Malonyl

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

372.230

Molecular Formula

C₂₃H₃₂O₄

SMILES

C1CC[C@](C2[C@@]1(c1c(CC2)cc(cc1)C(C)C)C)(C)COC(=O)CC(=O)O

XLogP

8.774

PSA

63.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Woldemichael GM, Franzblau SG, Zhang F, Wang Y, Timmermann BN.Inhibitory effect of sterols from Ruprechtia triflora and diterpenes from Calceolaria pinnifolia on the growth of Mycobacterium tuberculosis.Planta Med. 2003 Jul;69(7):628-31

Curator

Reshmi, vikramjitmandal

Record - 14 of 15 [TOP]

Compound ID

3589

Compound Structure

Plant Source

Caleolaria pinnifolia Cav. Common Name:NR

Source Family

Scrophulariaceae

Origin

Plant Part Used

Aerial

Extract

Dichloromethane:Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27 294)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.06 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

19 - Methylmalonyloxy - Ent - Isopimara - 8(9), 15 - Diene

PubChem ID

639656

Ethnomedicinal Information

PubMed ID [Source Literature]

12898418

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Diterpene, Malonyl

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

388.261

Molecular Formula

C₂₄H₃₆O₄

SMILES

O(C[C@]1([C@@H]2[C@](C3=C(CC2)C[C@](CC3)(C)C=C)(CCC1)C)C)C(=O)CC(=O)OC

XLogP

6.720

PSA

52.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Reshmi, vikramjitmandal

Record - 15 of 15 [TOP]

Compound ID

3590

Compound Structure

Plant Source

Caleolaria pinnifolia Cav. Common Name:NR

Source Family

Scrophulariaceae

Origin

Plant Part Used

Aerial

Extract

Dichloromethane:Methanol

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27 294)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.06 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

3 - Epi - Ursolic Acid

PubChem ID

64945

Ethnomedicinal Information

PubMed ID [Source Literature]

12898418

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Pentacyclic, Terpene, Triterpene, Acid, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

456.360

Molecular Formula

C₃₀H₄₈O₃

SMILES

O[C@@H]1C([C@H]2[C@@]([C@@H]3[C@]([C@]4(C(=CC3)[C@H]3[C@@](CC4)(CC[C@H]([C@@H]3C)C)C(=O)O)C)(CC2)C)(CC1)C)(C)C

XLogP

8.954

PSA

57.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Reshmi, vikramjitmandal

Developed by: CSIR- OSDD Unit, Delhi, India and Hosted by: Bioinformatics Centre, Institute of Microbial Technology, Sec-39A, Chandigarh, India.
The website has been tested on the latest version of Google Chrome (34.0.1847.137 m) and Mozilla Firefox (29.0.1)