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                  Page - 1 of 1                  Record - 1 of 6   [TOP]
Compound ID1542
Compound Structure
Plant SourceCorynostylis arborea (L.) S.F.Blake     Common Name:
Source FamilyViolaceae
OriginPeru
Plant Part UsedStem
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis (ATCC 27294)
Assay / Test DoneBACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]< 50 %
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]13678239
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35

Curator

                  Record - 2 of 6   [TOP]
Compound ID2016
Compound Structure
Plant SourceLeonia glycicarpa R. & P.     Common Name:
Source FamilyViolaceae
OriginPeru
Plant Part UsedStem
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis (ATCC 27294)
Assay / Test DoneBACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]< 50 %
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]13678239
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35

Curator

                  Record - 3 of 6   [TOP]
Compound ID2017
Compound Structure
Plant SourceLeonia racemosa Mart.     Common Name:
Source FamilyViolaceae
OriginPeru
Plant Part UsedBark
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis (ATCC 27294)
Assay / Test DoneBACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]< 50 %
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]13678239
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35

Curator

                  Record - 4 of 6   [TOP]
Compound ID2156
Compound Structure
Plant SourceMelicytos ramiflorus     Common Name:Mahoe
Source FamilyViolaceae
OriginNew Zealand
Plant Part UsedLeaf
Extract
Target BacteriaMycobacterium smegmatis
Assay / Test Done96 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationRheumatism and stomach wounds
PubMed ID [Source Literature]20537175
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25

Curator

                  Record - 5 of 6   [TOP]
Compound ID2789
Compound Structure
Plant SourceViola odorata Linn.     Common Name:Sweet Violet (English)
Source FamilyViolaceae
OriginEurope including Britain, Northern Asia, North Tropical and South America, India
Plant Part UsedLeaf
ExtractMethanol (14.35 %)
Target BacteriaMycobacterium aurum
Assay / Test DoneBroth Microdilution Method (BMM)
Positive Control Used (conc.)Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationAntiseptic, expectorant and used to treat cough, bronchitis, catarrh, flowers were used to treat consumption in the days of Charles II and were sold by all apothecaries
PubMed ID [Source Literature]11744296
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator

                  Record - 6 of 6   [TOP]
Compound ID2790
Compound Structure
Plant SourceViola odorata Linn.     Common Name:Sweet Violet (English)
Source FamilyViolaceae
OriginEurope including Britain, Northern Asia, North Tropical and South America, India
Plant Part UsedLeaf
ExtractMethanol (14.35 %)
Target BacteriaMycobacterium smegmatis
Assay / Test DoneBroth Microdilution Method (BMM)
Positive Control Used (conc.)Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationAntiseptic, expectorant and used to treat cough, bronchitis, catarrh, the flowers were used to treat consumption in the days of Charles II and were sold by all apothecaries
PubMed ID [Source Literature]11744296
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator


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