BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 11 [TOP]

Compound ID	1998
Compound Structure
Plant Source	Larrea tridentata Common Name:Chaparral, Creosote Bush
Source Family	Zygophyllaceae
Origin	Mexico
Plant Part Used	Aerial
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis H37Rv (Sensitive)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Kidney stones, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 2 of 11 [TOP]

Compound ID	1999
Compound Structure
Plant Source	Larrea tridentata Common Name:Chaparral, Creosote Bush
Source Family	Zygophyllaceae
Origin	Mexico
Plant Part Used	Aerial
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis H37Rv (Sensitive)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Kidney stones, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 3 of 11 [TOP]

Compound ID	2000
Compound Structure
Plant Source	Larrea tridentata Common Name:Chaparral, Creosote Bush
Source Family	Zygophyllaceae
Origin	Mexico
Plant Part Used	Aerial
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis H37Rv (Rifampin resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	100 - 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Kidney stones, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 4 of 11 [TOP]

Compound ID	2001
Compound Structure
Plant Source	Larrea tridentata Common Name:Chaparral, Creosote Bush
Source Family	Zygophyllaceae
Origin	Mexico
Plant Part Used	Aerial
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis (Isoniazid resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	100 - 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Kidney stones, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 5 of 11 [TOP]

Compound ID	2002
Compound Structure
Plant Source	Larrea tridentata Common Name:Chaparral, Creosote Bush
Source Family	Zygophyllaceae
Origin	Mexico
Plant Part Used	Aerial
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis (Streptomycin resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Kidney stones, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 6 of 11 [TOP]

Compound ID	2003
Compound Structure
Plant Source	Larrea tridentata Common Name:Chaparral, Creosote Bush
Source Family	Zygophyllaceae
Origin	Mexico
Plant Part Used	Aerial
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis (Ethambutol resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	100 - 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Kidney stones, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 7 of 11 [TOP]

Compound ID	2004
Compound Structure
Plant Source	Larrea tridentata Common Name:Chaparral, Creosote Bush
Source Family	Zygophyllaceae
Origin	Mexico
Plant Part Used	Aerial
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (Sensitive)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Kidney stones, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 8 of 11 [TOP]

Compound ID	2005
Compound Structure
Plant Source	Larrea tridentata Common Name:Chaparral, Creosote Bush
Source Family	Zygophyllaceae
Origin	Mexico
Plant Part Used	Aerial
Extract	Water
Target Bacteria	Mycobacterium tuberculosis H37Rv (Sensitive)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Kidney stones, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 9 of 11 [TOP]

Compound ID	2737
Compound Structure
Plant Source	Tribulus terrestris L. Common Name:Land Caltrops, Puncture Vine (English), Gokshura, Gokshuraka (Sanskrit)
Source Family	Zygophyllaceae
Origin	India
Plant Part Used	Whole plant
Extract	Chloroform
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)	Gentamicin (0.01 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	41600 µg dried plant/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, cough, asthma, general infectious diseases, antiseptic, disinfectant
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 10 of 11 [TOP]

Compound ID	3319
Compound Structure	N/A
Plant Source	Peganum harmala L. Common Name:Wild Rue, Foreign Henna, Syrian Rue (English), Haramal, Isband (Sanskrit)
Source Family	Zygophyllaceae
Origin	India
Plant Part Used	Aerial
Extract	Ethanol (80 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Agar Dilution - Streak Assay
Positive Control Used (conc.)	NR
Inhibition [%]	100 %
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Asthma, bronchitis, expectorant
PubMed ID [Source Literature]	541687
Extract Preparation
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Al-Shamma A, Mitscher LA.Comprehensive survey of indigenous Iraqi plants for potential economic value. 1. Screening results of 327 species for alkaloids and antimicrobial agents.J Nat Prod. 1979 Nov-Dec;42(6):633-42
Curator	Rachana, vikramjitmandal

Record - 11 of 11 [TOP]

Compound ID	3320
Compound Structure	N/A
Plant Source	Peganum harmala L. Common Name:Wild Rue, Foreign Henna, Syrian Rue (English), Haramal, Isband (Sanskrit)
Source Family	Zygophyllaceae
Origin	India
Plant Part Used	Seed
Extract	Ethanol (80 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Agar Dilution - Streak Assay
Positive Control Used (conc.)	NR
Inhibition [%]	100 %
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Asthma, bronchitis, expectorant
PubMed ID [Source Literature]	541687
Extract Preparation
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Al-Shamma A, Mitscher LA.Comprehensive survey of indigenous Iraqi plants for potential economic value. 1. Screening results of 327 species for alkaloids and antimicrobial agents.J Nat Prod. 1979 Nov-Dec;42(6):633-42
Curator	Rachana, vikramjitmandal

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