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                  Page - 1 of 1                  Record - 1 of 6   [TOP]
Compound ID1052
Compound StructureN/A
Plant SourceAdhatoda vasica Nees     Common Name:Malabar Nut Tree (English), Vasaka (Sanskrit)
Source FamilyAcanthaceae
OriginIndia
Plant Part UsedLeaf
ExtractWater
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMiddlebrook 7H9 Broth using BacT/ALERT 3D System
Positive Control Used (conc.)Isoniazid, Rifampin
Inhibition [%]70 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedN/A
PubChem IDNR
Ethnomedicinal InformationTreatment of tuberculosis, asthma and also as expectorants, bronchial disorders such as acute and chronic cough, bronchitis
PubMed ID [Source Literature]20571171
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Gupta R, Thakur B, Singh P, Singh HB, Sharma VD, Katoch VM, Chauhan SV.Anti-tuberculosis activity of selected medicinal plants against multi-drug resistant Mycobacterium tuberculosis isolates.Indian J Med Res. 2010 Jun;131:809-13

Curator

                  Record - 2 of 6   [TOP]
Compound ID1053
Compound StructureN/A
Plant SourceAdhatoda vasica Nees     Common Name:Malabar Nut Tree (English), Vasaka (Sanskrit)
Source FamilyAcanthaceae
OriginIndia
Plant Part UsedLeaf
ExtractWater
Target BacteriaMycobacterium tuberculosis (Multi - Drug Resistant isolate DKU 156)
Assay / Test DoneMiddlebrook 7H9 Broth using BacT/ALERT 3D System
Positive Control Used (conc.)Isoniazid, Rifampin
Inhibition [%]32 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedN/A
PubChem IDNR
Ethnomedicinal InformationTreatment of tuberculosis, asthma and also as expectorants, bronchial disorders such as acute and chronic cough, bronchitis
PubMed ID [Source Literature]20571171
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Gupta R, Thakur B, Singh P, Singh HB, Sharma VD, Katoch VM, Chauhan SV.Anti-tuberculosis activity of selected medicinal plants against multi-drug resistant Mycobacterium tuberculosis isolates.Indian J Med Res. 2010 Jun;131:809-13

Curator

                  Record - 3 of 6   [TOP]
Compound ID1054
Compound StructureN/A
Plant SourceAdhatoda vasica Nees     Common Name:Malabar Nut Tree (English),Vasaka (Sanskrit)
Source FamilyAcanthaceae
OriginIndia
Plant Part UsedLeaf
ExtractWater
Target BacteriaMDR stain of Mycobacterium tuberculosis (JAL1236)
Assay / Test DoneMiddlebrook 7H9 Broth using BacT/ALERT 3D System
Positive Control Used (conc.)Isoniazid, Rifampin
Inhibition [%]86 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedN/A
PubChem IDNR
Ethnomedicinal InformationTreatment of tuberculosis, asthma and also as expectorants, bronchial disorders such as acute and chronic cough, bronchitis
PubMed ID [Source Literature]20571171
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Gupta R, Thakur B, Singh P, Singh HB, Sharma VD, Katoch VM, Chauhan SV.Anti-tuberculosis activity of selected medicinal plants against multi-drug resistant Mycobacterium tuberculosis isolates.Indian J Med Res. 2010 Jun;131:809-13

Curator

                  Record - 4 of 6   [TOP]
Compound ID1055
Compound StructureN/A
Plant SourceAdhatoda vasica Nees     Common Name:Malabar Nut Tree (English), Vasaka (Sanskrit)
Source FamilyAcanthaceae
OriginIndia
Plant Part UsedLeaf
ExtractWater
Target BacteriaMycobacterium fortuitum (TMC 1529)
Assay / Test DoneMiddlebrook 7H9 Broth using BacT/ALERT 3D System
Positive Control Used (conc.)Isoniazid, Rifampin
Inhibition [%]0 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedN/A
PubChem IDNR
Ethnomedicinal InformationTreatment of tuberculosis, asthma and also as expectorants, bronchial disorders such as acute and chronic cough, bronchitis
PubMed ID [Source Literature]20571171
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Gupta R, Thakur B, Singh P, Singh HB, Sharma VD, Katoch VM, Chauhan SV.Anti-tuberculosis activity of selected medicinal plants against multi-drug resistant Mycobacterium tuberculosis isolates.Indian J Med Res. 2010 Jun;131:809-13

Curator

                  Record - 5 of 6   [TOP]
Compound ID1056
Compound Structure
DOWNLOAD:
Plant SourceAdhatoda vasica Nees     Common Name:Malabar Nut Tree (English), Vasaka (Sanskrit)
Source FamilyAcanthaceae
OriginIndia
Plant Part UsedLeaf
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneBroth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml128 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedBromhexine
PubChem ID   2442
Ethnomedicinal InformationTreatment of tuberculosis, asthma and also as expectorants, bronchial disorders such as acute and chronic cough, bronchitis
PubMed ID [Source Literature]8778507
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Cyclohexane, Amine, Haloginated
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight373.999
Molecular FormulaC14H20Br2N2
SMILESBrc1c(N)c(CN(C2CCCCC2)C)cc(Br)c1
XLogP4.004
PSA29.260
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O0
No. of S0
Reference(s)1) Grange JM, Snell NJ.Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro.J Ethnopharmacol. 1996 Jan;50(1):49-53

Curator

                  Record - 6 of 6   [TOP]
Compound ID1057
Compound Structure
DOWNLOAD:
Plant SourceAdhatoda vasica Nees     Common Name:Malabar Nut Tree (English), Vasaka (Sanskrit)
Source FamilyAcanthaceae
OriginIndia
Plant Part UsedLeaf
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneBroth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml64 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedAmbroxol
PubChem ID   2132
Ethnomedicinal InformationTreatment of tuberculosis, asthma and also as expectorants, bronchial disorders such as acute and chronic cough, bronchitis
PubMed ID [Source Literature]8778507
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Cyclohexane, Amine, Haloginated, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight375.979
Molecular FormulaC13H18Br2N2O
SMILESBrc1c(N)c(CNC2CCC(O)CC2)cc(Br)c1
XLogP2.524
PSA58.280
H-bond Donor3
H-bond Acceptor3
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O1
No. of S0
Reference(s)1) Grange JM, Snell NJ.Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro.J Ethnopharmacol. 1996 Jan;50(1):49-53

Curator


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