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                  Page - 1 of 1                  Record - 1 of 3   [TOP]
Compound ID1084
Compound Structure
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Plant SourceAilanthus altissima (Mill.) Swingle syn. Altissima glandulsa Desf.     Common Name:Tree of Heaven, Ailanto (English), Aralu (Sanskrit)
Source FamilySimaroubaceae
OriginIndia, China
Plant Part UsedMother tinture
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)Rifampin (0.031 µg/ml)
Inhibition [%]19 %
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedShinjulactone K
PubChem ID   460541
Ethnomedicinal InformationUsed for treating mental illness, nausea and headache, treating cardiac palpitation, asthma and epilepsy
PubMed ID [Source Literature]17276637
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Terpene, Triterpene, Quassinoid, Lactone, O-Acetyl, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight408.215
Molecular FormulaC22H32O7
SMILESO1[C@H]2[C@@]3([C@@H]([C@@]4([C@@H](C2)[C@@H](C[C@H](O)C4=O)C)C)[C@H](O)[C@H](OC(=O)C)[C@@H]([C@@H]3CC1=O)C)C
XLogP1.595
PSA110.130
H-bond Donor2
H-bond Acceptor7
No. of Rotatable Bond Count2
No. of Rings4
No. of N0
No. of O7
No. of S0
Reference(s)1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34

2) Rahman S, Fukamiya N, Okano M, Tagahara K, Lee KH.Anti-tuberculosis activity of quassinoids.Chem Pharm Bull (Tokyo). 1997 Sep;45(9):1527-9

Curator

                  Record - 2 of 3   [TOP]
Compound ID1085
Compound Structure
DOWNLOAD:
Plant SourceAilanthus altissima (Mill.) Swingle syn. Altissima glandulsa Desf.     Common Name:Tree of Heaven, Ailanto (English), Aralu (Sanskrit)
Source FamilySimaroubaceae
OriginIndia, China
Plant Part UsedMother tinture
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)Rifampin (0.031 µg/ml)
Inhibition [%]17 %
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedAilanthone
PubChem ID   72965
Ethnomedicinal InformationUsed for treating mental illness, nausea and headache, treating cardiac palpitation, asthma and epilepsy
PubMed ID [Source Literature]17276637
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Pentacyclic, Terpene, Triterpene, Quassinoid, Furanoid, Lactone, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight376.152
Molecular FormulaC20H24O7
SMILESO1[C@]2(O)[C@H]3[C@]4([C@H](OC(=O)C[C@H]4C(=C)[C@H]2O)C[C@@H]2[C@@]3([C@H](O)C(=O)C=C2C)C)C1
XLogP-0.429
PSA113.290
H-bond Donor3
H-bond Acceptor7
No. of Rotatable Bond Count0
No. of Rings5
No. of N0
No. of O7
No. of S0
Reference(s)1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34

2) Rahman S, Fukamiya N, Okano M, Tagahara K, Lee KH.Anti-tuberculosis activity of quassinoids.Chem Pharm Bull (Tokyo). 1997 Sep;45(9):1527-9

Curator

                  Record - 3 of 3   [TOP]
Compound ID1086
Compound Structure
DOWNLOAD:
Plant SourceAilanthus altissima (Mill.) Swingle syn. Altissima glandulsa Desf.     Common Name:Tree of Heaven, Ailanto (English), Aralu (Sanskrit)
Source FamilySimaroubaceae
OriginIndia, China
Plant Part UsedMother tinture
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)Rifampin (0.031 µg/ml)
Inhibition [%]15 %
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedShinjudilactone
PubChem ID   460534
Ethnomedicinal InformationUsed for treating mental illness, nausea and headache, treating cardiac palpitation, asthma and epilepsy
PubMed ID [Source Literature]17276637
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Pentacyclic, Terpene, Triterpene, Quassinoid, Lactone
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight376.152
Molecular FormulaC20H24O7
SMILESO1[C@H]2[C@]34[C@@H]([C@@]5([C@@H](C2)C(=CC(=O)[C@H]5O)C)C)[C@](O)(C([C@@H]3CC1=O)C)C(=O)OC4
XLogP0.413
PSA110.130
H-bond Donor2
H-bond Acceptor7
No. of Rotatable Bond Count0
No. of Rings5
No. of N0
No. of O7
No. of S0
Reference(s)1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34

2) Rahman S, Fukamiya N, Okano M, Tagahara K, Lee KH.Anti-tuberculosis activity of quassinoids.Chem Pharm Bull (Tokyo). 1997 Sep;45(9):1527-9

Curator


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