BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 6 [TOP]

Compound ID	1153
Compound Structure
Plant Source	Alpinia galanga (L.) Sw. Common Name:Galanga (English)
Source Family	Zingiberaceae
Origin	Malaysia
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1600 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Anonymous, 2010c. Khazanah herba warisan bumi: Portal Komuniti Herba 2) Http://www.melur.com/myherba.asp?plant id=94
Curator

Record - 2 of 6 [TOP]

Compound ID

3117

Compound Structure

Plant Source

Alpinia galanga Common Name:Thai Ginger

Source Family

Zingiberaceae

Origin

South Asia and Indonesia

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

1 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Acetylchavicole Acetate

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

16243360

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkene, Acetate

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

234.089

Molecular Formula

C₁₃H₁₄O₄

SMILES

C1cc(ccc1[C@H](C=C)OC(=O)C)OC(=O)C

XLogP

3.011

PSA

52.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Pauli GF, Case RJ, Inui T, Wang Y, Cho S, Fischer NH, Franzblau SG.New perspectives on natural products in TB drug research.Life Sci. 2005 Dec 22;78(5):485-94

Curator

KeyaMukherjee, reshmi

Record - 3 of 6 [TOP]

Compound ID	3168
Compound Structure	NR
Plant Source	Alpinia galanga Willd. Common Name:Greater galangal (English), Kulanjana (Sanskrit)
Source Family	Zingiberaceae
Origin	India
Plant Part Used	Rhizome
Extract	Essential oil
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]	100 %
Activity [MIC] µg/ml	25 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Tuberculous gland, bronchitis, pain in chest, expectorant, sore throat
PubMed ID [Source Literature]
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]
Reference(s)	1) Chopra, I.C., B.N. Khajuria and C.L. Chopra.Antibacterial properties of volatile principles from Alpinia galanga and Acorus calamus.Antibiotics and Chemotherapy 7, 378-383 (1957) 2) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator	Vikramjitmandal

Record - 4 of 6 [TOP]

Compound ID	3169
Compound Structure	NR
Plant Source	Alpinia galanga Willd. Common Name:Greater galangal (English), Kulanjana (Sanskrit)
Source Family	Zingiberaceae
Origin	India
Plant Part Used	Rhizome
Extract	Essential oil
Target Bacteria	Mycobacterium tuberculosis H52RS (Streptomycin resistant)
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]	100 %
Activity [MIC] µg/ml	25 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Tuberculous gland, bronchitis, pain in chest, expectorant, sore throat
PubMed ID [Source Literature]
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]
Reference(s)	1) Chopra, I.C., B.N. Khajuria and C.L. Chopra.Antibacterial properties of volatile principles from Alpinia galanga and Acorus calamus.Antibiotics and Chemotherapy 7, 378-383 (1957) 2) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator	Vikramjitmandal

Record - 5 of 6 [TOP]

Compound ID	3170
Compound Structure	NR
Plant Source	Alpinia galanga Willd. Common Name:Greater galangal (English), Kulanjana (Sanskrit)
Source Family	Zingiberaceae
Origin	India
Plant Part Used	Rhizome
Extract	Essential oil
Target Bacteria	Mycobacterium tuberculosis B19 - 1 (avian)
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]	100 %
Activity [MIC] µg/ml	25 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Tuberculous gland, bronchitis, pain in chest, expectorant, sore throat
PubMed ID [Source Literature]
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]
Reference(s)	1) Chopra, I.C., B.N. Khajuria and C.L. Chopra.Antibacterial properties of volatile principles from Alpinia galanga and Acorus calamus.Antibiotics and Chemotherapy 7, 378-383 (1957) 2) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator	Vikramjitmandal

Record - 6 of 6 [TOP]

Compound ID	3171
Compound Structure	NR
Plant Source	Alpinia galanga Willd. Common Name:Greater galangal (English), Kulanjana (Sanskrit)
Source Family	Zingiberaceae
Origin	India
Plant Part Used	Rhizome
Extract	Essential oil
Target Bacteria	Mycobacterium tuberculosis B19 - 3 (bovine)
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)	NR
Inhibition [%]	100 %
Activity [MIC] µg/ml	30 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Tuberculous gland, bronchitis, pain in chest, expectorant, sore throat
PubMed ID [Source Literature]
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Chopra, I.C., B.N. Khajuria and C.L. Chopra.Antibacterial properties of volatile principles from Alpinia galanga and Acorus calamus.Antibiotics and Chemotherapy 7, 378-383 (1957) 2) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator	Najiya-beegum, vikramjitmandal

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