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                  Page - 1 of 1                  Record - 1 of 5   [TOP]
Compound ID3711
Compound Structure
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Plant SourceAnethum graveolens L.     Common Name:NR
Source FamilyApiaceae (Umbelliferae)
OriginNR
Plant Part UsedWhole plant
ExtractHexane
Target BacteriaMycobacterium abscessus (ATCC 19977)
Assay / Test DoneColumbia Blood Agar
Positive Control Used (conc.)Ethambutol (128 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedFalcarindiol
PubChem ID   6436239
Ethnomedicinal InformationNR
PubMed ID [Source Literature]16317649
Extract PreparationNR
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight260.178
Molecular FormulaC17H24O2
SMILESO[C@@H](/C=CCCCCCCC)C#CC#C[C@@H](O)C=C
XLogP4.573
PSA40.460
H-bond Donor2
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings0
No. of N0
No. of O2
No. of S0
Reference(s)1) Stavri M, Gibbons S.The antimycobacterial constituents of dill (Anethum graveolens).Phytother Res. 2005 Nov;19(11):938-41

CuratorNajiya-beegum, vikramjitmandal

                  Record - 2 of 5   [TOP]
Compound ID3712
Compound Structure
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Plant SourceAnethum graveolens L.     Common Name:NR
Source FamilyApiaceae (Umbelliferae)
OriginNR
Plant Part UsedWhole plant
ExtractHexane
Target BacteriaMycobacterium aurum (Pasteur Institute 104482)
Assay / Test DoneColumbia Blood Agar
Positive Control Used (conc.)Ethambutol (0.5 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedFalcarindiol
PubChem ID   6436239
Ethnomedicinal InformationNR
PubMed ID [Source Literature]16317649
Extract PreparationNR
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight260.178
Molecular FormulaC17H24O2
SMILESO[C@@H](/C=CCCCCCCC)C#CC#C[C@@H](O)C=C
XLogP4.573
PSA40.460
H-bond Donor2
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings0
No. of N0
No. of O2
No. of S0
Reference(s)1) Stavri M, Gibbons S.The antimycobacterial constituents of dill (Anethum graveolens).Phytother Res. 2005 Nov;19(11):938-41

CuratorNajiya-beegum, vikramjitmandal

                  Record - 3 of 5   [TOP]
Compound ID3713
Compound Structure
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Plant SourceAnethum graveolens L.     Common Name:NR
Source FamilyApiaceae (Umbelliferae)
OriginNR
Plant Part UsedWhole plant
ExtractHexane
Target BacteriaMycobacterium phlei (ATCC 11758)
Assay / Test DoneColumbia Blood Agar
Positive Control Used (conc.)Ethambutol (2 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedFalcarindiol
PubChem ID   6436239
Ethnomedicinal InformationNR
PubMed ID [Source Literature]16317649
Extract PreparationNR
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight260.178
Molecular FormulaC17H24O2
SMILESO[C@@H](/C=CCCCCCCC)C#CC#C[C@@H](O)C=C
XLogP4.573
PSA40.460
H-bond Donor2
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings0
No. of N0
No. of O2
No. of S0
Reference(s)1) Stavri M, Gibbons S.The antimycobacterial constituents of dill (Anethum graveolens).Phytother Res. 2005 Nov;19(11):938-41

CuratorNajiya-beegum, vikramjitmandal

                  Record - 4 of 5   [TOP]
Compound ID3714
Compound Structure
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Plant SourceAnethum graveolens L.     Common Name:NR
Source FamilyApiaceae (Umbelliferae)
OriginNR
Plant Part UsedWhole plant
ExtractHexane
Target BacteriaMycobacterium smegmatis (ATCC 14468)
Assay / Test DoneColumbia Blood Agar
Positive Control Used (conc.)Ethambutol (0.5 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedFalcarindiol
PubChem ID   6436239
Ethnomedicinal InformationNR
PubMed ID [Source Literature]16317649
Extract PreparationNR
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight260.178
Molecular FormulaC17H24O2
SMILESO[C@@H](/C=CCCCCCCC)C#CC#C[C@@H](O)C=C
XLogP4.573
PSA40.460
H-bond Donor2
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings0
No. of N0
No. of O2
No. of S0
Reference(s)1) Stavri M, Gibbons S.The antimycobacterial constituents of dill (Anethum graveolens).Phytother Res. 2005 Nov;19(11):938-41

CuratorNajiya-beegum, vikramjitmandal

                  Record - 5 of 5   [TOP]
Compound ID4148
Compound Structure
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Plant SourceAnethum graveolens     Common Name:
Source FamilyApiaceae (Umbelliferae)
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium fortuitum ATCC 6841, Mycobacterium smegmatis ATCC 14468, Mycobacterium phlei ATCC 11758, Mycobacterium aurum Pasteur Institute 104482, Mycobacterium abscessus ATCC 19977
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml2-4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedNPMC3
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight260.178
Molecular FormulaC17H24O2
SMILESO[C@H](C#CC#C[C@H](O)/C=C/CCCCCCC)C=C
XLogP4.573
PSA40.460
H-bond Donor2
H-bond Acceptor2
No. of Rotatable Bond Count8
No. of Rings0
No. of N0
No. of O2
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) Rogoza, L. N.; Salakhutdinov, N. F.; Tolstikov, G. A. Anti-tubercular Activity of Natural Products: Recent Developments. In Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry; Tiwari, V. K. Ed.; Research Signpost: India, 2011; pp 103-120

Curator


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