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                  Page - 1 of 1                  Record - 1 of 20   [TOP]
Compound ID1258
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedDihydrocheleritrine
PubChem ID   485077
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight349.131
Molecular FormulaC21H19NO4
SMILESO1c2cc3c4N(Cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C
XLogP3.232
PSA40.160
H-bond Donor0
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 2 of 20   [TOP]
Compound ID1259
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrocheleritrine
PubChem ID   189060
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight379.142
Molecular FormulaC22H21NO5
SMILESO(C1N(c2c(c3c1c(OC)c(OC)cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.216
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count3
No. of Rings5
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 3 of 20   [TOP]
Compound ID1260
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6, 12 - Dimethoxydihydrocheleritrine
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight409.153
Molecular FormulaC23H23NO6
SMILESC1cc(c(c2c1c1c(N(C2OC)C)c2c(c(c1)OC)cc1OCOc1c2)OC)OC
XLogP2.561
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count4
No. of Rings5
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 4 of 20   [TOP]
Compound ID1261
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrosanguinarine
PubChem ID   14847270
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight363.111
Molecular FormulaC21H17NO5
SMILESO(C1N(c2c(c3c1c1OCOc1cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.143
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings6
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 5 of 20   [TOP]
Compound ID1262
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrochelirubine
PubChem ID   15932479
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight393.121
Molecular FormulaC22H19NO6
SMILESO(C1N(c2c(c3c1c1OCOc1cc3OC)ccc1c2cc2OCOc2c1)C)C
XLogP2.699
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count2
No. of Rings6
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 6 of 20   [TOP]
Compound ID1263
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedDihydrocheleritrine
PubChem ID   485077
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight349.131
Molecular FormulaC21H19NO4
SMILESO1c2cc3c4N(Cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C
XLogP3.232
PSA40.160
H-bond Donor0
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 7 of 20   [TOP]
Compound ID1264
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrocheleritrine
PubChem ID   189060
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight379.142
Molecular FormulaC22H21NO5
SMILESO(C1N(c2c(c3c1c(OC)c(OC)cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.216
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count3
No. of Rings5
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 8 of 20   [TOP]
Compound ID1265
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6, 12 - Dimethoxydihydrocheleritrine
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight409.153
Molecular FormulaC23H23NO6
SMILESC1cc(c(c2c1c1c(N(C2OC)C)c2c(c(c1)OC)cc1OCOc1c2)OC)OC
XLogP2.561
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count4
No. of Rings5
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 9 of 20   [TOP]
Compound ID1266
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrosanguinarine
PubChem ID   14847270
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight363.111
Molecular FormulaC21H17NO5
SMILESO(C1N(c2c(c3c1c1OCOc1cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.143
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings6
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 10 of 20   [TOP]
Compound ID1267
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrochelirubine
PubChem ID   15932479
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight393.121
Molecular FormulaC22H19NO6
SMILESO(C1N(c2c(c3c1c1OCOc1cc3OC)ccc1c2cc2OCOc2c1)C)C
XLogP2.699
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count2
No. of Rings6
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 11 of 20   [TOP]
Compound ID1268
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedDihydrocheleritrine
PubChem ID   485077
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight349.131
Molecular FormulaC21H19NO4
SMILESO1c2cc3c4N(Cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C
XLogP3.232
PSA40.160
H-bond Donor0
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 12 of 20   [TOP]
Compound ID1269
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrocheleritrine
PubChem ID   189060
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight379.142
Molecular FormulaC22H21NO5
SMILESO(C1N(c2c(c3c1c(OC)c(OC)cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.216
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count3
No. of Rings5
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 13 of 20   [TOP]
Compound ID1270
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6, 12 - Dimethoxydihydrocheleritrine
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight409.153
Molecular FormulaC23H23NO6
SMILESC1cc(c(c2c1c1c(N(C2OC)C)c2c(c(c1)OC)cc1OCOc1c2)OC)OC
XLogP2.561
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count4
No. of Rings5
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 14 of 20   [TOP]
Compound ID1271
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrosanguinarine
PubChem ID   14847270
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight363.111
Molecular FormulaC21H17NO5
SMILESO(C1N(c2c(c3c1c1OCOc1cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.143
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings6
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 15 of 20   [TOP]
Compound ID1272
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrochelirubine
PubChem ID   15932479
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight393.121
Molecular FormulaC22H19NO6
SMILESO(C1N(c2c(c3c1c1OCOc1cc3OC)ccc1c2cc2OCOc2c1)C)C
XLogP2.699
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count2
No. of Rings6
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 16 of 20   [TOP]
Compound ID1273
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedDihydrocheleritrine
PubChem ID   485077
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight349.131
Molecular FormulaC21H19NO4
SMILESO1c2cc3c4N(Cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C
XLogP3.232
PSA40.160
H-bond Donor0
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 17 of 20   [TOP]
Compound ID1274
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrocheleritrine
PubChem ID   189060
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight379.142
Molecular FormulaC22H21NO5
SMILESO(C1N(c2c(c3c1c(OC)c(OC)cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.216
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count3
No. of Rings5
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 18 of 20   [TOP]
Compound ID1275
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6, 12 - Dimethoxydihydrocheleritrine
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight409.153
Molecular FormulaC23H23NO6
SMILESC1cc(c(c2c1c1c(N(C2OC)C)c2c(c(c1)OC)cc1OCOc1c2)OC)OC
XLogP2.561
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count4
No. of Rings5
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 19 of 20   [TOP]
Compound ID1276
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrosanguinarine
PubChem ID   14847270
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight363.111
Molecular FormulaC21H17NO5
SMILESO(C1N(c2c(c3c1c1OCOc1cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.143
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings6
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 20 of 20   [TOP]
Compound ID1277
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrochelirubine
PubChem ID   15932479
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight393.121
Molecular FormulaC22H19NO6
SMILESO(C1N(c2c(c3c1c1OCOc1cc3OC)ccc1c2cc2OCOc2c1)C)C
XLogP2.699
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count2
No. of Rings6
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator


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