BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 22 [TOP]

Compound ID	1385
Compound Structure
Plant Source	Cassia fistula Common Name:Fistula, Laburnum, Purging Fistula, Golden Shower, Amaltas
Source Family	Fabaceae
Origin	Mexico
Plant Part Used	Fruit
Extract	Hexane, methanol
Target Bacteria
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, healing ulcers, useful against skin diseases, liver troubles, tuberculous glands, haematemesis, pruritus, leucoderm, diabetes, rheumatism
PubMed ID [Source Literature]	13680821
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Jimenez-Arellanes A, Meckes M, Ramirez R, Torres J, Luna-Herrera J. Activity against multidrug-resistant Mycobacterium tuberculosis in Mexican plants used to treat respiratory diseases. Phytother Res. 2003 Sep;17(8):903-8
Curator

Record - 2 of 22 [TOP]

Compound ID	1386
Compound Structure
Plant Source	Cassia petersiana Bolle Common Name:Monkey Pod
Source Family	Fabaceae
Origin	Africa
Plant Part Used	Bark
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 3 of 22 [TOP]

Compound ID	1387
Compound Structure
Plant Source	Cassia petersiana Bolle Common Name:Monkey pod
Source Family	Fabaceae
Origin	Africa
Plant Part Used	Bark
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis 2 (Clinical isolates resistant to Streptomycin, Rifampin, Ethambutol, Isoniazid)
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (100 µg/ml), Isoniazid (4.6 µg/ml), Ethambutol (12 µg/ml), Streptomycin (120 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 4 of 22 [TOP]

Compound ID	1388
Compound Structure
Plant Source	Cassia sp. Common Name:
Source Family	Fabaceae
Origin	Peru
Plant Part Used	Stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml) and Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 5 of 22 [TOP]

Compound ID

3843

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (bovine isolate [NCTC 8578])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

74 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2, 5 - Dihydroxybenzaldehyde

PubChem ID

70949

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Aldehyde, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

138.032

Molecular Formula

C₇H₆O₃

SMILES

Oc1c(cc(O)cc1)C=O

XLogP

0.950

PSA

57.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Wong SY, Grant IR, Friedman M, Elliott CT, Situ C.Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis.Appl Environ Microbiol. 2008 Oct;74(19):5986-90. Epub 2008 Aug 1

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 6 of 22 [TOP]

Compound ID

3844

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (human isolate [ATCC 43015])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

74 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2, 5 - Dihydroxybenzaldehyde

PubChem ID

70949

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Aldehyde, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

138.032

Molecular Formula

C₇H₆O₃

SMILES

Oc1c(cc(O)cc1)C=O

XLogP

0.950

PSA

57.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 7 of 22 [TOP]

Compound ID

3845

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (raw - milk isolate [806R])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

74 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2, 5 - Dihydroxybenzaldehyde

PubChem ID

70949

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Aldehyde, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

138.032

Molecular Formula

C₇H₆O₃

SMILES

Oc1c(cc(O)cc1)C=O

XLogP

0.950

PSA

57.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 8 of 22 [TOP]

Compound ID

3846

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (bovine isolate [NCTC 8578])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

90.4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - Hydroxy - 5 - Methoxybenzaldehyde

PubChem ID

95695

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Aldehyde, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

152.047

Molecular Formula

C₈H₈O₃

SMILES

O(c1cc(c(O)cc1)C=O)C

XLogP

1.469

PSA

46.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 9 of 22 [TOP]

Compound ID

3847

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (human isolate [ATCC 43015])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

90.4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - Hydroxy - 5 - Methoxybenzaldehyde

PubChem ID

95695

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Aldehyde, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

152.047

Molecular Formula

C₈H₈O₃

SMILES

O(c1cc(c(O)cc1)C=O)C

XLogP

1.469

PSA

46.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 10 of 22 [TOP]

Compound ID

3848

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (raw - milk isolate [806R])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

90.4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - Hydroxy - 5 - Methoxybenzaldehyde

PubChem ID

95695

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Aldehyde, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

152.047

Molecular Formula

C₈H₈O₃

SMILES

O(c1cc(c(O)cc1)C=O)C

XLogP

1.469

PSA

46.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 11 of 22 [TOP]

Compound ID

3849

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (bovine isolate [NCTC 8578])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

72.2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Carvacrol

PubChem ID

10364

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Terpene, Monoterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

150.104

Molecular Formula

C₁₀H₁₄O

SMILES

Oc1cc(C(C)C)ccc1C

XLogP

3.556

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 12 of 22 [TOP]

Compound ID

3850

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (human isolate [ATCC 43015])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

72.2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Carvacrol

PubChem ID

10364

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Terpene, Monoterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

150.104

Molecular Formula

C₁₀H₁₄O

SMILES

Oc1cc(C(C)C)ccc1C

XLogP

3.556

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 13 of 22 [TOP]

Compound ID

3851

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (raw - milk isolate [806R])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

72.2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Carvacrol

PubChem ID

10364

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Terpene, Monoterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

150.104

Molecular Formula

C₁₀H₁₄O

SMILES

Oc1cc(C(C)C)ccc1C

XLogP

3.556

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 14 of 22 [TOP]

Compound ID

3852

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (bovine isolate [NCTC 8578])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

26.2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cinnamon (Cassia) oil

PubChem ID

6850781

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Mixture, Alkene, Phenol, OIL

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

164.084

Molecular Formula

C₁₉H₂₂O₂

SMILES

O(c1cc(CC=C)ccc1O)C.c1(ccccc1)/C=C/C

XLogP

2.484

PSA

29.460

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 15 of 22 [TOP]

Compound ID

3853

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (human isolate [ATCC 43015])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

26.2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cinnamon (Cassia) oil

PubChem ID

6850781

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Mixture, Alkene, Phenol, OIL

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

164.084

Molecular Formula

C₁₉H₂₂O₂

SMILES

O(c1cc(CC=C)ccc1O)C.c1(ccccc1)/C=C/C

XLogP

2.484

PSA

29.460

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 16 of 22 [TOP]

Compound ID

3854

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (raw - milk isolate [806R])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

26.2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cinnamon (Cassia) oil

PubChem ID

6850781

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Mixture, Alkene, Phenol, OIL

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

164.084

Molecular Formula

C₁₉H₂₂O₂

SMILES

O(c1cc(CC=C)ccc1O)C.c1(ccccc1)/C=C/C

XLogP

2.484

PSA

29.460

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 17 of 22 [TOP]

Compound ID	3855
Compound Structure	NR
Plant Source	Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR
Source Family	NR
Origin	NR
Plant Part Used	NR
Extract	NR
Target Bacteria	Mycobacterium avium subsp. paratuberculosis (bovine isolate [NCTC 8578])
Assay / Test Done	Macro - broth susceptibility testing using Bactec 460 system
Positive Control Used (conc.)	Rifampin (< 0.6 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	68.2 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Oregano (Origanum) oil (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	18676709
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Wong SY, Grant IR, Friedman M, Elliott CT, Situ C.Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis.Appl Environ Microbiol. 2008 Oct;74(19):5986-90. Epub 2008 Aug 1
Curator	KeyaMukherjee, Farzana Shamsudeen

Record - 18 of 22 [TOP]

Compound ID	3856
Compound Structure	NR
Plant Source	Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR
Source Family	NR
Origin	NR
Plant Part Used	NR
Extract	NR
Target Bacteria	Mycobacterium avium subsp. paratuberculosis (human isolate [ATCC 43015])
Assay / Test Done	Macro - broth susceptibility testing using Bactec 460 system
Positive Control Used (conc.)	Rifampin (< 0.6 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	68.2 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Oregano (Origanum) oil (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	18676709
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Wong SY, Grant IR, Friedman M, Elliott CT, Situ C.Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis.Appl Environ Microbiol. 2008 Oct;74(19):5986-90. Epub 2008 Aug 1
Curator	KeyaMukherjee, Farzana Shamsudeen

Record - 19 of 22 [TOP]

Compound ID	3857
Compound Structure	NR
Plant Source	Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR
Source Family	NR
Origin	NR
Plant Part Used	NR
Extract	NR
Target Bacteria	Mycobacterium avium subsp. paratuberculosis (raw - milk isolate [806R])
Assay / Test Done	Macro - broth susceptibility testing using Bactec 460 system
Positive Control Used (conc.)	Rifampin (< 0.6 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	68.2 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Oregano (Origanum) oil (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	18676709
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Wong SY, Grant IR, Friedman M, Elliott CT, Situ C.Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis.Appl Environ Microbiol. 2008 Oct;74(19):5986-90. Epub 2008 Aug 1
Curator	KeyaMukherjee, Farzana Shamsudeen

Record - 20 of 22 [TOP]

Compound ID

3858

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (bovine isolate [NCTC 8578])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25.9 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Trans - Cinnamaldehyde

PubChem ID

637511

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Aldehyde

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

132.058

Molecular Formula

C₉H₈O

SMILES

O=C/C=C/c1ccccc1

XLogP

3.985

PSA

17.070

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 21 of 22 [TOP]

Compound ID

3859

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (human isolate [ATCC 43015])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25.9 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Trans - Cinnamaldehyde

PubChem ID

637511

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Aldehyde

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

132.058

Molecular Formula

C₉H₈O

SMILES

O=C/C=C/c1ccccc1

XLogP

3.985

PSA

17.070

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 22 of 22 [TOP]

Compound ID

3860

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (raw - milk isolate [806R])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25.9 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Trans - Cinnamaldehyde

PubChem ID

637511

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Aldehyde

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

132.058

Molecular Formula

C₉H₈O

SMILES

O=C/C=C/c1ccccc1

XLogP

3.985

PSA

17.070

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

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