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                  Page - 1 of 1                  Record - 1 of 9   [TOP]
Compound ID1474
Compound Structure
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Plant SourceClausena excavata Burm. f.     Common Name:Clausena (English)
Source FamilyRutaceae
OriginIndia
Plant Part UsedRhizome
ExtractChloroform
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedDentatin
PubChem ID   342801
Ethnomedicinal InformationFever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold
PubMed ID [Source Literature]12624822
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Coumarin, Benzopyran, Alkene, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]Against KB and BC - 1 cell lines
Molecular Weight326.152
Molecular FormulaC20H22O4
SMILESO1c2c(C(C)(C)C=C)c3oc(=O)ccc3c(OC)c2C=CC1(C)C
XLogP4.812
PSA35.530
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) Sunthitikawinsakul A, Kongkathip N, Kongkathip B, Phonnakhu S, Daly JW, Spande TF, Nimit Y, Rochanaruangrai S.Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.Planta Med. 2003 Feb;69(2):155-7

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

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                  Record - 2 of 9   [TOP]
Compound ID1475
Compound Structure
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Plant SourceClausena excavata Burm. f.     Common Name:Clausena (English)
Source FamilyRutaceae
OriginIndia
Plant Part UsedRhizome
ExtractChloroform
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedNor - Dentatin
PubChem ID   5495613
Ethnomedicinal InformationFever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold
PubMed ID [Source Literature]12624822
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Coumarin, Benzopyran, Alkene, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]Against KB and BC - 1 cell lines
Molecular Weight312.136
Molecular FormulaC19H20O4
SMILESO1c2c(C(C)(C)C=C)c3oc(=O)ccc3c(O)c2C=CC1(C)C
XLogP4.293
PSA46.530
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) Sunthitikawinsakul A, Kongkathip N, Kongkathip B, Phonnakhu S, Daly JW, Spande TF, Nimit Y, Rochanaruangrai S.Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.Planta Med. 2003 Feb;69(2):155-7

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator

                  Record - 3 of 9   [TOP]
Compound ID1476
Compound Structure
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Plant SourceClausena excavata Burm. f.     Common Name:Clausena (English)
Source FamilyRutaceae
OriginIndia
Plant Part UsedRhizome
ExtractChloroform
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedClausenidin
PubChem ID   5315947
Ethnomedicinal InformationFever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold
PubMed ID [Source Literature]12624822
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Coumarin, Chromone, Alkene, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]Against KB and BC - 1 cell lines
Molecular Weight328.131
Molecular FormulaC19H20O5
SMILESO1C(CC(=O)c2c1c(C(C)(C)C=C)c1oc(=O)ccc1c2O)(C)C
XLogP3.411
PSA63.600
H-bond Donor1
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Sunthitikawinsakul A, Kongkathip N, Kongkathip B, Phonnakhu S, Daly JW, Spande TF, Nimit Y, Rochanaruangrai S.Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.Planta Med. 2003 Feb;69(2):155-7

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator

                  Record - 4 of 9   [TOP]
Compound ID1477
Compound Structure
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Plant SourceClausena excavata Burm. f.     Common Name:Clausena (English)
Source FamilyRutaceae
OriginIndia
Plant Part UsedRhizome
ExtractChloroform
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified3 - Formylcarbazole
PubChem ID   20746
Ethnomedicinal InformationFever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold
PubMed ID [Source Literature]12624822
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Carbazole, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight181.089
Molecular FormulaC13H11N
SMILES[nH]1c2c(c3c1cccc3)cc(cc2)C
XLogP4.401
PSA15.790
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings3
No. of N1
No. of O0
No. of S0
Reference(s)1) Sunthitikawinsakul A, Kongkathip N, Kongkathip B, Phonnakhu S, Daly JW, Spande TF, Nimit Y, Rochanaruangrai S.Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.Planta Med. 2003 Feb;69(2):155-7

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator

                  Record - 5 of 9   [TOP]
Compound ID1478
Compound Structure
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Plant SourceClausena excavata Burm. f.     Common Name:Clausena (English)
Source FamilyRutaceae
OriginIndia
Plant Part UsedRhizome
ExtractChloroform
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedMukonal
PubChem ID   504068
Ethnomedicinal InformationFever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold
PubMed ID [Source Literature]12624822
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Alkaloid, Aldehyde, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight211.063
Molecular FormulaC13H9NO2
SMILESOc1cc2[nH]c3c(c2cc1C=O)cccc3
XLogP2.984
PSA53.090
H-bond Donor2
H-bond Acceptor3
No. of Rotatable Bond Count1
No. of Rings3
No. of N1
No. of O2
No. of S0
Reference(s)1) Sunthitikawinsakul A, Kongkathip N, Kongkathip B, Phonnakhu S, Daly JW, Spande TF, Nimit Y, Rochanaruangrai S.Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.Planta Med. 2003 Feb;69(2):155-7

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator

                  Record - 6 of 9   [TOP]
Compound ID1479
Compound Structure
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Plant SourceClausena excavata Burm. f.     Common Name:Clausena (English)
Source FamilyRutaceae
OriginIndia
Plant Part Used Rhizome
ExtractHexane
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified3 - Methoxycarbonylcarbazole
PubChem IDNR
Ethnomedicinal InformationFever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold
PubMed ID [Source Literature]12624822
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Alkaloid, Carbazole, Ester
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight225.079
Molecular FormulaC14H11NO2
SMILES[nH]1c2c(c3c1ccc(c3)C(=O)OC)cccc2
XLogP3.425
PSA42.090
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings3
No. of N1
No. of O2
No. of S0
Reference(s)1) Sunthitikawinsakul A, Kongkathip N, Kongkathip B, Phonnakhu S, Daly JW, Spande TF, Nimit Y, Rochanaruangrai S.Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.Planta Med. 2003 Feb;69(2):155-7

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator

                  Record - 7 of 9   [TOP]
Compound ID1480
Compound Structure
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Plant SourceClausena excavata Burm. f.     Common Name:Clausena (English)
Source FamilyRutaceae
OriginIndia
Plant Part UsedRhizome
ExtractHexane
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified2 - Hydroxy - 3 - Formyl - 7 - Methoxycarbazole
PubChem ID   189687
Ethnomedicinal InformationFever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold
PubMed ID [Source Literature]12624822
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Alkaloid, Carbazole, Aldehyde, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight241.074
Molecular FormulaC14H11NO3
SMILESO(c1cc2[nH]c3c(c2cc1)cc(c(O)c3)C=O)C
XLogP2.329
PSA62.320
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings3
No. of N1
No. of O3
No. of S0
Reference(s)1) Sunthitikawinsakul A, Kongkathip N, Kongkathip B, Phonnakhu S, Daly JW, Spande TF, Nimit Y, Rochanaruangrai S.Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.Planta Med. 2003 Feb;69(2):155-7

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator

                  Record - 8 of 9   [TOP]
Compound ID1481
Compound Structure
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Plant SourceClausena excavata Burm. f.     Common Name:Clausena (English)
Source FamilyRutaceae
OriginIndia
Plant Part UsedRoot
ExtractChloroform
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedClauszoline J
PubChem IDNR
Ethnomedicinal InformationFever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold
PubMed ID [Source Literature]12624822
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Alkaloid, Carbazole, Ether, Acid
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight271.084
Molecular FormulaC15H13NO4
SMILES[nH]1c2c(cc(c(c2)OC)C(=O)O)c2c1cc(cc2)OC
XLogP2.559
PSA71.550
H-bond Donor2
H-bond Acceptor5
No. of Rotatable Bond Count3
No. of Rings3
No. of N1
No. of O4
No. of S0
Reference(s)1) Sunthitikawinsakul A, Kongkathip N, Kongkathip B, Phonnakhu S, Daly JW, Spande TF, Nimit Y, Rochanaruangrai S.Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.Planta Med. 2003 Feb;69(2):155-7

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator

                  Record - 9 of 9   [TOP]
Compound ID1482
Compound Structure
DOWNLOAD:
Plant SourceClausena excavata Burm. f.     Common Name:Clausena (English)
Source FamilyRutaceae
OriginIndia
Plant Part UsedRoot
ExtractChloroform
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedO - Methylated Clausenidin
PubChem ID   504066
Ethnomedicinal InformationFever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold
PubMed ID [Source Literature]12624822
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Coumarin, Chromone, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight342.147
Molecular FormulaC20H22O5
SMILESO1C(CC(=O)c2c1c(C(C)(C)C=C)c1oc(=O)ccc1c2OC)(C)C
XLogP3.930
PSA52.600
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Sunthitikawinsakul A, Kongkathip N, Kongkathip B, Phonnakhu S, Daly JW, Spande TF, Nimit Y, Rochanaruangrai S.Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.Planta Med. 2003 Feb;69(2):155-7

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator


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