|  Home  |Search   |  Browse  |Similarity   |Data Visualization  |Submission  |Contact Us  |  













                  Page - 1 of 1                  Record - 1 of 9   [TOP]
Compound ID3563
Compound Structure
DOWNLOAD:
Plant SourceCryptolepis sanguinolenta     Common Name:Nibima
Source FamilyApocynaceae
OriginWest Africa
Plant Part UsedRoot
ExtractAmmonia moistened chloroform
Target BacteriaMycobacterium fortuitum
Assay / Test DoneMTT Assay
Positive Control Used (conc.)Ethambutol (8 µg/ml), Isoniazid (0.5 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml16 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCryptolepine hydrochloride
PubChem ID   156093
Ethnomedicinal InformationAntimycobacterial, antimalarial
PubMed ID [Source Literature]12722159
Extract PreparationCryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt
Chemical Classification [Active Compound]Aromatic, Quinoline, Alkaloid, Indole
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium
Cytotoxicity Assay [AID]NR
Molecular Weight232.100
Molecular FormulaC16H13ClN2
SMILESCl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C
XLogP4.596
PSA15.600
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O0
No. of S0
Reference(s)1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

CuratorWvarsha, rachanake

                  Record - 2 of 9   [TOP]
Compound ID3564
Compound Structure
DOWNLOAD:
Plant SourceCryptolepis sanguinolenta     Common Name:Nibima
Source FamilyApocynaceae
OriginWest Africa
Plant Part UsedRoot
ExtractAmmonia moistened chloroform
Target BacteriaMycobacterium smegmatis (ATCC 14468)
Assay / Test DoneMTT Assay
Positive Control Used (conc.)Ethambutol (0.25 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCryptolepine hydrochloride
PubChem ID   156093
Ethnomedicinal InformationAntimycobacterial, antimalarial
PubMed ID [Source Literature]12722159
Extract PreparationCryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt
Chemical Classification [Active Compound]Aromatic, Quinoline, Alkaloid, Indole
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium
Cytotoxicity Assay [AID]NR
Molecular Weight232.100
Molecular FormulaC16H13ClN2
SMILESCl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C
XLogP4.596
PSA15.600
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O0
No. of S0
Reference(s)1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

CuratorWvarsha, rachanake

                  Record - 3 of 9   [TOP]
Compound ID3565
Compound Structure
DOWNLOAD:
Plant SourceCryptolepis sanguinolenta     Common Name:Nibima
Source FamilyApocynaceae
OriginWest Africa
Plant Part UsedRoot
ExtractAmmonia moistened chloroform
Target BacteriaMycobacterium phlei
Assay / Test DoneMTT Assay
Positive Control Used (conc.)Ethambutol (1 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCryptolepine hydrochloride
PubChem ID   156093
Ethnomedicinal InformationAntimycobacterial, antimalarial
PubMed ID [Source Literature]12722159
Extract PreparationCryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt
Chemical Classification [Active Compound]Aromatic, Quinoline, Alkaloid, Indole
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium
Cytotoxicity Assay [AID]NR
Molecular Weight232.100
Molecular FormulaC16H13ClN2
SMILESCl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C
XLogP4.596
PSA15.600
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O0
No. of S0
Reference(s)1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

CuratorWvarsha, rachanake

                  Record - 4 of 9   [TOP]
Compound ID3566
Compound Structure
DOWNLOAD:
Plant SourceCryptolepis sanguinolenta     Common Name:Nibima
Source FamilyApocynaceae
OriginWest Africa
Plant Part UsedRoot
ExtractAmmonia moistened chloroform
Target BacteriaMycobacterium abscessus
Assay / Test DoneMTT Assay
Positive Control Used (conc.)Ethambutol (128 µg/ml), Isoniazid (32 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml32 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCryptolepine hydrochloride
PubChem ID   156093
Ethnomedicinal InformationAntimycobacterial, antimalarial
PubMed ID [Source Literature]12722159
Extract PreparationCryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt
Chemical Classification [Active Compound]Aromatic, Quinoline, Alkaloid, Indole
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium
Cytotoxicity Assay [AID]NR
Molecular Weight232.100
Molecular FormulaC16H13ClN2
SMILESCl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C
XLogP4.596
PSA15.600
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O0
No. of S0
Reference(s)1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

CuratorWvarsha, rachanake

                  Record - 5 of 9   [TOP]
Compound ID3567
Compound Structure
DOWNLOAD:
Plant SourceCryptolepis sanguinolenta     Common Name:Nibima
Source FamilyApocynaceae
OriginWest Africa
Plant Part UsedRoot
ExtractAmmonia moistened chloroform
Target BacteriaMycobacterium aurum
Assay / Test DoneMTT Assay
Positive Control Used (conc.)Ethambutol (1 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCryptolepine hydrochloride
PubChem ID   156093
Ethnomedicinal InformationAntimycobacterial,AntimalAerial
PubMed ID [Source Literature]12722159
Extract PreparationCryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt
Chemical Classification [Active Compound]Aromatic, Quinoline, Alkaloid, Indole
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium
Cytotoxicity Assay [AID]NR
Molecular Weight232.100
Molecular FormulaC16H13ClN2
SMILESCl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C
XLogP4.596
PSA15.600
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O0
No. of S0
Reference(s)1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

CuratorWvarsha, rachanake

                  Record - 6 of 9   [TOP]
Compound ID3568
Compound Structure
DOWNLOAD:
Plant SourceCryptolepis sanguinolenta     Common Name:Nibima
Source FamilyApocynaceae
OriginWest Africa
Plant Part UsedRoot
ExtractAmmonia moistened chloroform
Target BacteriaMycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test DoneMTT Assay
Positive Control Used (conc.)Streptomycin sulphate (6.25 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCryptolepine hydrochloride
PubChem ID   156093
Ethnomedicinal InformationAntimycobacterial,AntimalAerial
PubMed ID [Source Literature]12722159
Extract PreparationCryptolepine was isolated from Cryptolepis sanguinolenta roots and crystallized as the hydrochloride salt
Chemical Classification [Active Compound]Aromatic, Quinoline, Alkaloid, Indole
Media / Broth Used [Antimicrobial Assay/Test]Mueller - Hinton broth, Colombia blood agar, 7H9 Middle Brook medium
Cytotoxicity Assay [AID]NR
Molecular Weight232.100
Molecular FormulaC16H13ClN2
SMILESCl.n1(c2c(nc3c2cccc3)cc2c1cccc2)C
XLogP4.596
PSA15.600
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O0
No. of S0
Reference(s)1) Gibbons S, Fallah F, Wright CW.Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta.Phytother Res. 2003 Apr;17(4):434-6

CuratorWvarsha, rachanake

                  Record - 7 of 9   [TOP]
Compound ID4129
Compound Structure
DOWNLOAD:
Plant SourceCryptolepis sanguinolenta     Common Name:
Source FamilyApocynaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium aurum
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCryptolepine
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Indole, Quinoline
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight233.108
Molecular FormulaC16H13N2
SMILESC[n+]1c2c(cccc2)cc2c1c1ccccc1[nH]2
XLogP4.611
PSA19.670
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O0
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) Rogoza, L. N.; Salakhutdinov, N. F.; Tolstikov, G. A. Anti-tubercular Activity of Natural Products: Recent Developments. In Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry; Tiwari, V. K. Ed.; Research Signpost: India, 2011; pp 103-120

Curator

                  Record - 8 of 9   [TOP]
Compound ID4130
Compound Structure
DOWNLOAD:
Plant SourceCryptolepis sanguinolenta     Common Name:
Source FamilyApocynaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium phlei
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCryptolepine
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Indole, Quinoline
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight233.108
Molecular FormulaC16H13N2
SMILESC[n+]1c2c(cccc2)cc2c1c1ccccc1[nH]2
XLogP4.611
PSA19.670
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O0
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) Rogoza, L. N.; Salakhutdinov, N. F.; Tolstikov, G. A. Anti-tubercular Activity of Natural Products: Recent Developments. In Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry; Tiwari, V. K. Ed.; Research Signpost: India, 2011; pp 103-120

Curator

                  Record - 9 of 9   [TOP]
Compound ID4131
Compound Structure
DOWNLOAD:
Plant SourceCryptolepis sanguinolenta     Common Name:
Source FamilyApocynaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium fortuitum
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml16 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCryptolepine
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Indole, Quinoline
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight233.108
Molecular FormulaC16H13N2
SMILESC[n+]1c2c(cccc2)cc2c1c1ccccc1[nH]2
XLogP4.611
PSA19.670
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O0
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) Rogoza, L. N.; Salakhutdinov, N. F.; Tolstikov, G. A. Anti-tubercular Activity of Natural Products: Recent Developments. In Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry; Tiwari, V. K. Ed.; Research Signpost: India, 2011; pp 103-120

Curator


Developed by: CSIR- OSDD Unit, Delhi, India and Hosted by: Bioinformatics Centre,   Institute of Microbial Technology, Sec-39A, Chandigarh, India.
The website has been tested on the latest version of Google Chrome (34.0.1847.137 m) and Mozilla Firefox (29.0.1)