BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 5 [TOP]

Compound ID	1785
Compound Structure
Plant Source	Galipea officinalis Common Name:Angustura Vera
Source Family	Rutaceae
Origin	South America
Plant Part Used	Bark
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:320 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used to treat diarrhoea and fevers
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91
Curator

Record - 2 of 5 [TOP]

Compound ID

1786

Compound Structure

Plant Source

Galipea officinalis Common Name:Angustura Vera

Source Family

Rutaceae

Origin

South America

Plant Part Used

Bark

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Isoniazid (0.12 µg/ml), Rifampin (0.001 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cusparine

PubChem ID

442893

Ethnomedicinal Information

Used to treat diarrhoea and fevers

PubMed ID [Source Literature]

10232071

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Alkaloid, Quinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

307.121

Molecular Formula

C₁₉H₁₇NO₃

SMILES

O1c2cc(CCc3nc4c(c(OC)c3)cccc4)ccc2OC1

XLogP

4.688

PSA

40.580

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Houghton PJ, Woldemariam TZ, Watanabe Y, Yates M.Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis.Planta Med. 1999 Apr;65(3):250-4

Curator

Record - 3 of 5 [TOP]

Compound ID

1787

Compound Structure

Plant Source

Galipea officinalis Common Name:Angustura Vera

Source Family

Rutaceae

Origin

South America

Plant Part Used

Bark

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Isoniazid (0.12 µg/ml), Rifampin (0.001 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Galipine

PubChem ID

68235

Ethnomedicinal Information

Used to treat diarrhoea and fevers

PubMed ID [Source Literature]

10232071

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Quinoline, Alkaloid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

323.152

Molecular Formula

C₂₀H₂₁NO₃

SMILES

O(c1c2c(nc(CCc3cc(OC)c(OC)cc3)c1)cccc2)C

XLogP

4.761

PSA

40.580

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Houghton PJ, Woldemariam TZ, Watanabe Y, Yates M.Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis.Planta Med. 1999 Apr;65(3):250-4

Curator

Record - 4 of 5 [TOP]

Compound ID

1788

Compound Structure

Plant Source

Galipea officinalis Common Name:Angustura Vera

Source Family

Rutaceae

Origin

South America

Plant Part Used

Bark

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Isoniazid (0.12 µg/ml), Rifampin (0.001 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

4 - Methoxy - 2 - N - Pentylquinoleine

PubChem ID

3009247

Ethnomedicinal Information

Used to treat diarrhoea and fevers

PubMed ID [Source Literature]

10232071

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Alkyl, Alkaloid, Quinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

229.147

Molecular Formula

C₁₅H₁₉NO

SMILES

O(c1cc(nc2c1cccc2)CCCCC)C

XLogP

5.146

PSA

22.120

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Houghton PJ, Woldemariam TZ, Watanabe Y, Yates M.Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis.Planta Med. 1999 Apr;65(3):250-4

Curator

Record - 5 of 5 [TOP]

Compound ID

1789

Compound Structure

Plant Source

Galipea officinalis Common Name:Angustura Vera

Source Family

Rutaceae

Origin

South America

Plant Part Used

Bark

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Isoniazid (0.12 µg/ml), Rifampin (0.001 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

N - Methyl - 2 - Quinolone

PubChem ID

11820

Ethnomedicinal Information

Used to treat diarrhoea and fevers

PubMed ID [Source Literature]

10232071

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Quinolone, Alkaloid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

159.068

Molecular Formula

C₁₀H₉NO

SMILES

O=c1n(c2c(cc1)cccc2)C

XLogP

2.261

PSA

17.070

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Houghton PJ, Woldemariam TZ, Watanabe Y, Yates M.Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis.Planta Med. 1999 Apr;65(3):250-4

Curator

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