BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 13 [TOP]

Compound ID	1809
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)	Rifampin (0.533 ± 0.08 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (2.7 ± 0.36 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	18182260
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80
Curator

Record - 2 of 13 [TOP]

Compound ID	1810
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)	Rifampin (0.23 ± 0.06 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (0.116 ± 0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	18182260
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80
Curator

Record - 3 of 13 [TOP]

Compound ID	1811
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Ethyl acetate fraction
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)	Rifampin (0.533 ± 0.08 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (2.7 ± 0.36 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	116.67 ± 14.43 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	18182260
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80
Curator

Record - 4 of 13 [TOP]

Compound ID	1812
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Ethyl acetate fraction
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)	Rifampin (0.23 ± 0.06 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (0.116 ± 0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	18182260
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80
Curator

Record - 5 of 13 [TOP]

Compound ID	1813
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Column fraction
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)	Rifampin (0.533 ± 0.08 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (2.7 ± 0.36 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	58.33 ± 7.21 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	18182260
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80
Curator

Record - 6 of 13 [TOP]

Compound ID	1814
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Column fraction
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)	Rifampin (0.23 ± 0.06 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (0.116 ± 0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	116.67 ± 14.43 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	18182260
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80
Curator

Record - 7 of 13 [TOP]

Compound ID

1815

Compound Structure

Plant Source

Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)

Source Family

Fabaceae

Origin

India, Africa

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

BACTEC Assay

Positive Control Used (conc.)

Rifampin (0.23 ± 0.06 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (0.116 ± 0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

29.16 ± 3.61 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Glabridin

PubChem ID

124052

Ethnomedicinal Information

Expectorant, consumption, bronchitis, chest complaint, cough

PubMed ID [Source Literature]

18182260

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzopyran, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C[C@H](Cc2c1c1c(OC(C=C1)(C)C)cc2)c1c(O)cc(O)cc1

XLogP

3.207

PSA

58.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra roots.J Ethnopharmacol. 2008 Mar 5;116(2):377-80

Curator

Record - 8 of 13 [TOP]

Compound ID	1816
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 9 of 13 [TOP]

Compound ID	1817
Compound Structure
Plant Source	Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source Family	Fabaceae
Origin	India, Africa
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 10 of 13 [TOP]

Compound ID

1818

Compound Structure

Plant Source

Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)

Source Family

Fabaceae

Origin

India, Africa

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Lico - Isoflavone

PubChem ID

392443

Ethnomedicinal Information

Expectorant, consumption, bronchitis, chest complaint, cough

PubMed ID [Source Literature]

17276637

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Flavonoid, Benzopyran, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

354.110

Molecular Formula

C₂₀H₁₈O₆

SMILES

O1C(C=Cc2c(O)c(C3COc4c(C3=O)c(O)cc(O)c4)ccc12)(C)C

XLogP

1.167

PSA

96.220

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34

Curator

Record - 11 of 13 [TOP]

Compound ID

1819

Compound Structure

Plant Source

Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)

Source Family

Fabaceae

Origin

India, Africa

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium smegmatis

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Lico - Isoflavone

PubChem ID

392443

Ethnomedicinal Information

Expectorant, consumption, bronchitis, chest complaint, cough

PubMed ID [Source Literature]

17276637

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Flavonoid, Benzopyran, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

354.110

Molecular Formula

C₂₀H₁₈O₆

SMILES

O1C(C=Cc2c(O)c(C3COc4c(C3=O)c(O)cc(O)c4)ccc12)(C)C

XLogP

1.167

PSA

96.220

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34

Curator

Record - 12 of 13 [TOP]

Compound ID	1820
Compound Structure
Plant Source	Glycyrrhiza glabra L. var. glabra Common Name:
Source Family	Fabaceae
Origin	Turkey
Plant Part Used	Root
Extract	Ethanol (70 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5
Curator

Record - 13 of 13 [TOP]

Compound ID

3971

Compound Structure

Plant Source

Glycyrrhiza glabra L. Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)

Source Family

Fabaceae

Origin

India, Africa

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

BACTEC Assay

Positive Control Used (conc.)

Rifampin (0.23 ± 0.06 µg/ml), Isoniazid (0.116 ± 0.03 µg/ml), Streptomycin (2.7 ± 0.36 µg/ml), Ethambutol (0.116 ± 0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

29.16 ± 3.61 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Glabridin

PubChem ID

124052

Ethnomedicinal Information

Expectorant, consumption, bronchitis, chest complaint, cough

PubMed ID [Source Literature]

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Benzopyran, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

324.136

Molecular Formula

C₂₀H₂₀O₄

SMILES

O1C[C@H](Cc2c1c1c(OC(C=C1)(C)C)cc2)c1c(O)cc(O)cc1

XLogP

3.207

PSA

58.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

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