BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 10 [TOP]

Compound ID	1889
Compound Structure
Plant Source	Hypericum perforatum L. Common Name:Common St. John's Wort (English)
Source Family	Hypericaceae
Origin	India, British Columbia
Plant Part Used	Aerial
Extract	Chloroform
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)	Gentamicin (0.01 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Wound healing, antiseptic and disinfectant qualities,cough, expectorant, chronic catarrh of lungs
PubMed ID [Source Literature]	3325696
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52
Curator

Record - 2 of 10 [TOP]

Compound ID	1890
Compound Structure
Plant Source	Hypericum perforatum L. Common Name:Common St. John's wort (English)
Source Family	Hypericaceae
Origin	India, British Columbia
Plant Part Used	Aerial
Extract	Methanol
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Gentamicin (10 µg/Disc)
Inhibition [%]
Activity [MIC] µg/ml	2000000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	15.1 mm, 20.0 mm, > 25mm (control)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Wound healing, antiseptic and disinfectant qualities,cough, expectorant, chronic catarrh of lungs
PubMed ID [Source Literature]	1453710
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) McCutcheon AR, Ellis SM, Hancock RE, Towers GH.Antibiotic screening of medicinal plants of the British Columbian native peoples.J Ethnopharmacol. 1992 Oct;37(3):213-23
Curator

Record - 3 of 10 [TOP]

Compound ID	1893
Compound Structure
Plant Source	Hypericum perforatum L. Common Name:Common St. John's Wort (English)
Source Family	Hypericaceae
Origin	India, British Columbia
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid (10 µl of 10 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	10 µg extract/Disc
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Wound healing, antiseptic and disinfectant qualities,cough, expectorant, chronic catarrh of lungs
PubMed ID [Source Literature]	1453710
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) McCutcheon AR, Ellis SM, Hancock RE, Towers GH.Antibiotic screening of medicinal plants of the British Columbian native peoples.J Ethnopharmacol. 1992 Oct;37(3):213-23
Curator

Record - 4 of 10 [TOP]

Compound ID	1894
Compound Structure
Plant Source	Hypericum perforatum L. Common Name:Common St. John's Wort (English)
Source Family	Hypericaceae
Origin	India, British Columbia
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid (10 µl of 10 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg extract/Disc
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Wound healing, antiseptic and disinfectant qualities,cough, expectorant, chronic catarrh of lungs
PubMed ID [Source Literature]	1453710
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) McCutcheon AR, Ellis SM, Hancock RE, Towers GH.Antibiotic screening of medicinal plants of the British Columbian native peoples.J Ethnopharmacol. 1992 Oct;37(3):213-23
Curator

Record - 5 of 10 [TOP]

Compound ID	3331
Compound Structure	NR
Plant Source	Hypericum perforatum Common Name:NR
Source Family	Hypericaceae
Origin	Spanish Mediterranean Area
Plant Part Used	Aerial
Extract	Chloroform
Target Bacteria	Mycobacterium phlei (CECT 3009)
Assay / Test Done	NR
Positive Control Used (conc.)	Gentamicin (10 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	> 1 x 10⁶ µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans
PubMed ID [Source Literature]	3325696
Extract Preparation
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52
Curator	Najiya Beegum

Record - 6 of 10 [TOP]

Compound ID	3444
Compound Structure
Plant Source	Hypericum perforatum L. Common Name:Common St. John's Wort (English)
Source Family	Hypericaceae
Origin	India
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	0.1 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, chronic catarrh of lungs, cough
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Fitzpatrick, F.K.Plant substances achieve against mycobacterium tuberculoses.Antibiotics and Chemotherapy, Vol 4, Pages 528-536
Curator

Record - 7 of 10 [TOP]

Compound ID	3445
Compound Structure
Plant Source	Hypericum perforatum L. Common Name:Common St. John's Wort (English)
Source Family	Hypericaceae
Origin	India
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid (10 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	At 10 µg/Disk
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) McCutcheon AR, Roberts TE, Gibbons E, Ellis SM, Babiuk LA, Hancock RE, Towers GH.Antiviral screening of British Columbian medicinal plants.J Ethnopharmacol. 1995 Dec 1;49(2):101-10
Curator

Record - 8 of 10 [TOP]

Compound ID	3446
Compound Structure
Plant Source	Hypericum perforatum L. Common Name:Common St. John's Wort (English)
Source Family	Hypericaceae
Origin	India
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	50 µg/Disk
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]	8847882
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) McCutcheon AR, Roberts TE, Gibbons E, Ellis SM, Babiuk LA, Hancock RE, Towers GH.Antiviral screening of British Columbian medicinal plants.J Ethnopharmacol. 1995 Dec 1;49(2):101-10
Curator

Record - 9 of 10 [TOP]

Compound ID	3449
Compound Structure
Plant Source	Hypericum perforatum L. Common Name:Common St. John's Wort (English)
Source Family	Hypericaceae
Origin	India
Plant Part Used	Flower
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Wound healing, antiseptic and disinfectant qualities,cough, expectorant, chronic catarrh of lungs
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Frisbey, A., Roberts, J.M., Jennings, J.C., Gottshall, R.Y., Lucas, E.H., 1953. The occurrence of antibacterial substances in seed plants with special refer-ence to Mycobacterium tuberculosis. Michigan State University Agricultural Applied Science
Curator

Record - 10 of 10 [TOP]

Compound ID	3450
Compound Structure
Plant Source	Hypericum perforatum L. Common Name:Common St. John's Wort (English)
Source Family	Hypericaceae
Origin	India
Plant Part Used	Leaf
Extract	Water
Target Bacteria
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Wound healing, antiseptic and disinfectant qualities,cough, expectorant, chronic catarrh of lungs
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Frisbey, A., Roberts, J.M., Jennings, J.C., Gottshall, R.Y., Lucas, E.H., 1953. The occurrence of antibacterial substances in seed plants with special refer-ence to Mycobacterium tuberculosis. Michigan State University Agricultural Applied Science 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

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