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                  Page - 1 of 1                  Record - 1 of 11   [TOP]
Compound ID2853
Compound StructureN/A
Plant SourceHyptis mutabilis     Common Name:Tropical Bushmint
Source FamilyLamiaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractLeaf and stem (0.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneColorimetric Macrodilution Method, following the protocol described by Abate et al. (1998)
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedMixture of Essential oils (Mixture)
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19753839
Extract PreparationMicrowave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Mixture
Media / Broth Used [Antimicrobial Assay/Test]Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]NR
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorReshmi, KeyaMukherjee

                  Record - 2 of 11   [TOP]
Compound ID3882
Compound Structure
DOWNLOAD:
Plant SourceHyptis mutabilis     Common Name:Tropical Bushmint
Source FamilyLamiaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (0.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedFenchone (17.1 %)
PubChem ID   14525
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Monoterpene, Ketone
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight152.120
Molecular FormulaC10H16O
SMILESO=C1C2(CC(C1(C)C)CC2)C
XLogP1.507
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O1
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 3 of 11   [TOP]
Compound ID3883
Compound Structure
DOWNLOAD:
Plant SourceHyptis mutabilis     Common Name:Tropical Bushmint
Source FamilyLamiaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (0.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified1, 8 - Cineol (12.6 %)
PubChem ID   2758
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Monoterpene, Ether
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight154.136
Molecular FormulaC10H18O
SMILESO1C2(CCC(C1(C)C)CC2)C
XLogP2.595
PSA9.230
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings0
No. of N0
No. of O1
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 4 of 11   [TOP]
Compound ID3884
Compound Structure
DOWNLOAD:
Plant SourceHyptis mutabilis     Common Name:Tropical Bushmint
Source FamilyLamiaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (0.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedBicyclogermacrene (8.7 %)
PubChem ID   5315347
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Sesquiterpene
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight204.188
Molecular FormulaC15H24
SMILESC1(C2C1/C=C(/CC/C=C(/CC2)C)C)(C)C
XLogP5.999
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 5 of 11   [TOP]
Compound ID3885
Compound Structure
DOWNLOAD:
Plant SourceHyptis mutabilis     Common Name:Tropical Bushmint
Source FamilyLamiaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (0.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedGermacrene D (6.2 %)
PubChem ID   5373727
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Terpene, Sesquiterpene
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight204.188
Molecular FormulaC15H24
SMILESC1(C(C)C)CC/C(=CCCC(=C)/C=C1)/C
XLogP6.294
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count1
No. of Rings1
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 6 of 11   [TOP]
Compound ID3886
Compound Structure
DOWNLOAD:
Plant SourceHyptis mutabilis     Common Name:Tropical Bushmint
Source FamilyLamiaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (0.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedLimonene (4.8 %)
PubChem ID   22311
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Terpene, Monoterpene
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight136.125
Molecular FormulaC10H16
SMILESC1(CCC(=CC1)C)C(=C)C
XLogP3.729
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count1
No. of Rings1
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 7 of 11   [TOP]
Compound ID3887
Compound Structure
DOWNLOAD:
Plant SourceHyptis mutabilis     Common Name:Tropical Bushmint
Source FamilyLamiaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (0.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identifiedα - Pinene (3.8 %)
PubChem ID   6654
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Monoterpene
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight136.125
Molecular FormulaC10H16
SMILESC1(C2CC1C(=CC2)C)(C)C
XLogP4.177
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings1
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 8 of 11   [TOP]
Compound ID3888
Compound Structure
DOWNLOAD:
Plant SourceHyptis mutabilis     Common Name:Tropical Bushmint
Source FamilyLamiaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (0.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identifiedβ - Pinene (3.7 %)
PubChem ID   14896
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Monoterpene
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight136.125
Molecular FormulaC10H16
SMILESC1(C2CC1C(=C)CC2)(C)C
XLogP4.222
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings1
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 9 of 11   [TOP]
Compound ID3889
Compound Structure
DOWNLOAD:
Plant SourceHyptis mutabilis     Common Name:Tropical Bushmint
Source FamilyLamiaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (0.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identifiedβ - Boubonene (3.4 %)
PubChem ID   62566
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Diterpene
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight204.188
Molecular FormulaC15H24
SMILES[C@]12([C@@H]([C@@H]3[C@H]1CCC3=C)[C@@H](CC2)C(C)C)C
XLogP6.544
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 10 of 11   [TOP]
Compound ID3890
Compound Structure
DOWNLOAD:
Plant SourceHyptis mutabilis     Common Name:Tropical Bushmint
Source FamilyLamiaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (0.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedSpathulenol (3.0 %)
PubChem ID   522266
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Sesquiterpene, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight220.183
Molecular FormulaC15H24O
SMILESOC1(C2C3C(C3CCC(=C)C2CC1)(C)C)C
XLogP4.157
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings3
No. of N0
No. of O1
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 11 of 11   [TOP]
Compound ID3891
Compound Structure
DOWNLOAD:
Plant SourceHyptis mutabilis     Common Name:Tropical Bushmint
Source FamilyLamiaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (0.3 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedTrans - β - Caryophyllene (10.9 %)
PubChem ID   5281515
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Sesquiterpene
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight204.188
Molecular FormulaC15H24
SMILESC1([C@H]2[C@H](C1)C(=C)CC/C=C(/CC2)C)(C)C
XLogP6.044
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorKeyaMukherjee, Farzana Shamsudeen


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