BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 10 [TOP]

Compound ID	1921
Compound Structure
Plant Source	Inula racemosa Hook. f. syn. Inula helenium L. Common Name:Elecampane (English), Pushkaramula, Pushkara, Paushkara, Padmapatra, Kaashmira, Kushtha - bheda (Sanskrit)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, lung disorders, cough, expectorant, random screening, bronchitis
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 2 of 10 [TOP]

Compound ID	1922
Compound Structure
Plant Source	Inula racemosa Hook. f. syn. Inula helenium L. Common Name:Elecampane (English), Pushkaramula, Pushkara, Paushkara, Padmapatra, Kaashmira, Kushtha - bheda (Sanskrit)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	1:80 dilution
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, lung disorders, cough, expectorant, random screening, bronchitis
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91
Curator

Record - 3 of 10 [TOP]

Compound ID	1923
Compound Structure
Plant Source	Inula racemosa Hook. f. syn. Inula helenium L. Common Name:Elecampane (English), Pushkaramula, Pushkara, Paushkara, Padmapatra, Kaashmira, Kushtha - bheda (Sanskrit)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Root
Extract	Hexane, dichloromethane
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Radiorespirometric Bioassay
Positive Control Used (conc.)	Rifampin (0.25 – 0.125 µg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, lung disorders, cough, expectorant, random screening, bronchitis
PubMed ID [Source Literature]	10364842
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Cantrell CL, Abate L, Fronczek FR, Franzblau SG, Quijano L, Fischer NH.Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa.Planta Med. 1999 May;65(4):351-5 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 4 of 10 [TOP]

Compound ID	1924
Compound Structure
Plant Source	Inula racemosa Hook. f. syn. Inula helenium L. Common Name:Elecampane (English), Pushkaramula, Pushkara, Paushkara, Padmapatra, Kaashmira, Kushtha - bheda (Sanskrit)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Radiorespirometric Bioassay
Positive Control Used (conc.)	Rifampin (0.25 – 0.125 µg/ml)
Inhibition [%]	83 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, lung disorders, cough, expectorant, random screening, bronchitis
PubMed ID [Source Literature]	10364842
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Cantrell CL, Abate L, Fronczek FR, Franzblau SG, Quijano L, Fischer NH.Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa.Planta Med. 1999 May;65(4):351-5 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 5 of 10 [TOP]

Compound ID	1925
Compound Structure
Plant Source	Inula racemosa Hook. f. syn. Inula helenium L. Common Name:Elecampane (English), Pushkaramula, Pushkara, Paushkara, Padmapatra, Kaashmira, Kushtha - bheda (Sanskrit)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium avium, Mycobacterium smegmatis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, lung disorders, cough, expectorant, random screening, bronchitis
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 6 of 10 [TOP]

Compound ID	1926
Compound Structure
Plant Source	Inula racemosa Hook. f. syn. Inula helenium L. Common Name:Elecampane (English), Pushkaramula, Pushkara, Paushkara, Padmapatra, Kaashmira, Kushtha - bheda (Sanskrit)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Whole plant
Extract	Chloroform
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	8900 µg/ml of dried plant
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, lung disorders, cough, expectorant, random screening, bronchitis
PubMed ID [Source Literature]	3325696
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52
Curator

Record - 7 of 10 [TOP]

Compound ID	1927
Compound Structure
Plant Source	Inula racemosa Hook. f. syn. Inula helenium L. Common Name:Elecampane (English), Pushkaramula, Pushkara, Paushkara, Padmapatra, Kaashmira, Kushtha - bheda (Sanskrit)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	11800 µg/ml of dried plant
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, lung disorders, cough, expectorant, random screening, bronchitis
PubMed ID [Source Literature]	3325696
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52
Curator

Record - 8 of 10 [TOP]

Compound ID

1928

Compound Structure

Plant Source

Inula racemosa Hook. f. syn. Inula helenium L. Common Name:Elecampane (English), Pushkaramula, Pushkara, Paushkara, Padmapatra, Kaashmira, Kushtha - bheda (Sanskrit)

Source Family

Asteraceae (Compositae)

Origin

India

Plant Part Used

Root

Extract

Hexane, dichloromethane, methanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

32 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Alantolactone

PubChem ID

72724

Ethnomedicinal Information

Tuberculosis, lung disorders, cough, expectorant,Random screening,bronchitis

PubMed ID [Source Literature]

10364842

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Sesquiterpene, Lactone

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

232.146

Molecular Formula

C₁₅H₂₀O₂

SMILES

O1[C@@H]2C[C@@]3(C(=C[C@@H]2C(=C)C1=O)[C@H](CCC3)C)C

XLogP

3.443

PSA

26.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cantrell CL, Abate L, Fronczek FR, Franzblau SG, Quijano L, Fischer NH.Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa.Planta Med. 1999 May;65(4):351-5

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator

Record - 9 of 10 [TOP]

Compound ID

1929

Compound Structure

Plant Source

Inula racemosa Hook. f. syn. Inula helenium L. Common Name:Elecampane (English), Pushkaramula, Pushkara, Paushkara, Padmapatra, Kaashmira, Kushtha - bheda (Sanskrit)

Source Family

Asteraceae (Compositae)

Origin

India, USA

Plant Part Used

Root

Extract

Hexane, dichloromethane, methanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Rifampin (0.25 - 0.125 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

32 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Isoalantolactone

PubChem ID

73285

Ethnomedicinal Information

Tuberculosis, lung disorders, cough, expectorant, random screening, bronchitis

PubMed ID [Source Literature]

10364842

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Sesquiterpene, Lactone

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

232.146

Molecular Formula

C₁₅H₂₀O₂

SMILES

O1[C@@H]2C[C@@]3([C@@H](C[C@@H]2C(=C)C1=O)C(=C)CCC3)C

XLogP

3.681

PSA

26.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 10 of 10 [TOP]

Compound ID

1930

Compound Structure

Plant Source

Inula racemosa Hook. f. syn. Inula helenium L. Common Name:Elecampane (English), Pushkaramula, Pushkara, Paushkara, Padmapatra, Kaashmira, Kushtha - bheda (Sanskrit)

Source Family

Asteraceae (Compositae)

Origin

India

Plant Part Used

Root

Extract

Hexane, dichloromethane, methanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

> 128 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

11, 13 - Dihydroisoalantolactone

PubChem ID

474517

Ethnomedicinal Information

Tuberculosis, lung disorders, cough, expectorant, random screening, bronchitis

PubMed ID [Source Literature]

10364842

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Sesquiterpene, Lactone

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

234.162

Molecular Formula

C₁₅H₂₂O₂

SMILES

O1[C@H]2[C@H](C[C@@H]3[C@@](C2)(CCCC3=C)C)C(C1=O)C

XLogP

3.863

PSA

26.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

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