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                  Page - 1 of 1                  Record - 1 of 4   [TOP]
Compound ID2113
Compound Structure
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Plant SourceMagnolia virginiana     Common Name:
Source FamilyMagnoliaceae
OriginUSA
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)Rifampin (0.25 - 0.125 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml32 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCostunolide
PubChem ID   5281437
Ethnomedicinal InformationIn the treatment of malaria and is also taken internally in the treatment of colds, bronchial diseases, upper respiratory tract infections, rheumatism and gout
PubMed ID [Source Literature]9747541
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Sesquiterpene, Lactone
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight232.146
Molecular FormulaC15H20O2
SMILESO1[C@H]2[C@@H](CC/C(=C/CC/C(=C/2)/C)/C)C(=C)C1=O
XLogP3.308
PSA26.300
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O2
No. of S0
Reference(s)1) Fischer NH, Lu T, Cantrell CL, Castaņeda-Acosta J, Quijano L, Franzblau SG.Antimycobacterial evaluation of germacranolides.Phytochemistry. 1998 Sep;49(2):559-64

Curator

                  Record - 2 of 4   [TOP]
Compound ID2114
Compound Structure
DOWNLOAD:
Plant SourceMagnolia virginiana     Common Name:
Source FamilyMagnoliaceae
OriginUSA
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)Rifampin (0.25 - 0.125 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml16 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedParthenolide
PubChem ID   7251185
Ethnomedicinal InformationCytotoxic, anti-tumor, anti-bacterial, anti-fungal, anti-inflammatory, european fever, migraine
PubMed ID [Source Literature]9747541
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Sesquiterpene, Lactone, Epoxy
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight248.141
Molecular FormulaC15H20O3
SMILESO1[C@]2([C@H]1[C@H]1OC(=O)C(=C)[C@@H]1CC/C(=C/CC2)/C)C
XLogP2.449
PSA38.830
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings3
No. of N0
No. of O3
No. of S0
Reference(s)1) Fischer NH, Lu T, Cantrell CL, Castaņeda-Acosta J, Quijano L, Franzblau SG.Antimycobacterial evaluation of germacranolides.Phytochemistry. 1998 Sep;49(2):559-64

Curator

                  Record - 3 of 4   [TOP]
Compound ID2116
Compound Structure
DOWNLOAD:
Plant SourceMagnolia virginiana     Common Name:
Source FamilyMagnoliaceae
OriginUSA
Plant Part Used
Extract
Target BacteriaMycobacterium avium
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)Clarithroycin (1 - 2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml128 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCostunolide
PubChem ID   5281437
Ethnomedicinal InformationIn the treatment of malaria and is also taken internally in the treatment of colds, bronchial diseases, upper respiratory tract infections, rheumatism and gout
PubMed ID [Source Literature]9747541
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Sesquiterpene, Lactone
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight232.146
Molecular FormulaC15H20O2
SMILESO1[C@H]2[C@@H](CC/C(=C/CC/C(=C/2)/C)/C)C(=C)C1=O
XLogP3.308
PSA26.300
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings2
No. of N0
No. of O2
No. of S0
Reference(s)1) Fischer NH, Lu T, Cantrell CL, Castaņeda-Acosta J, Quijano L, Franzblau SG.Antimycobacterial evaluation of germacranolides.Phytochemistry. 1998 Sep;49(2):559-64

Curator

                  Record - 4 of 4   [TOP]
Compound ID2117
Compound Structure
DOWNLOAD:
Plant SourceMagnolia virginiana     Common Name:
Source FamilyMagnoliaceae
OriginUSA
Plant Part Used
Extract
Target BacteriaMycobacterium avium
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)Clarithroycin (1 - 2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml64 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedParthenolide
PubChem ID   7251185
Ethnomedicinal InformationCytotoxic, anti-tumor, anti-bacterial, anti-fungal, anti-inflammatory, european fever, migraine
PubMed ID [Source Literature]9747541
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Sesquiterpene, Lactone, Epoxy
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight248.141
Molecular FormulaC15H20O3
SMILESO1[C@]2([C@H]1[C@H]1OC(=O)C(=C)[C@@H]1CC/C(=C/CC2)/C)C
XLogP2.449
PSA38.830
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings3
No. of N0
No. of O3
No. of S0
Reference(s)1) Fischer NH, Lu T, Cantrell CL, Castaņeda-Acosta J, Quijano L, Franzblau SG.Antimycobacterial evaluation of germacranolides.Phytochemistry. 1998 Sep;49(2):559-64

Curator


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