BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 4 [TOP]

Compound ID

2317

Compound Structure

Plant Source

Peucedanum ostruthium Koch Common Name:Masterwort

Source Family

Apiaceae (Umbelliferae)

Origin

China

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium aurum (PI 104 482)

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

1 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Ostruthin

PubChem ID

5281420

Ethnomedicinal Information

Has folkloric reputation for the topical treatment of athletes foot

PubMed ID [Source Literature]

12709907

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Coumarin, Prenylated, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

298.157

Molecular Formula

C₁₉H₂₂O₃

SMILES

O1c2c(cc(C/C=C(/CCC=C(C)C)C)c(O)c2)ccc1=O

XLogP

5.348

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Schinkovitz A, Gibbons S, Stavri M, Cocksedge MJ, Bucar F.Ostruthin: an antimycobacterial coumarin from the Roots of Peucedanum ostruthium. Planta Med. 2003 Apr;69(4):369-7

Curator

Record - 2 of 4 [TOP]

Compound ID

2318

Compound Structure

Plant Source

Peucedanum ostruthium Koch Common Name:Masterwort

Source Family

Apiaceae (Umbelliferae)

Origin

China

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium fortuitum (ATCC 6841)

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Ostruthin

PubChem ID

5281420

Ethnomedicinal Information

Has folkloric reputation for the topical treatment of athletes foot

PubMed ID [Source Literature]

12709907

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Coumarin, Prenylated, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

298.157

Molecular Formula

C₁₉H₂₂O₃

SMILES

O1c2c(cc(C/C=C(/CCC=C(C)C)C)c(O)c2)ccc1=O

XLogP

5.348

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Schinkovitz A, Gibbons S, Stavri M, Cocksedge MJ, Bucar F.Ostruthin: an antimycobacterial coumarin from the Roots of Peucedanum ostruthium. Planta Med. 2003 Apr;69(4):369-7

Curator

Record - 3 of 4 [TOP]

Compound ID

2319

Compound Structure

Plant Source

Peucedanum ostruthium Koch Common Name:Masterwort

Source Family

Apiaceae (Umbelliferae)

Origin

China

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium phlei (ATCC 11 758)

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Ostruthin

PubChem ID

5281420

Ethnomedicinal Information

Has folkloric reputation for the topical treatment of athletes foot

PubMed ID [Source Literature]

12709907

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Coumarin, Prenylated, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

298.157

Molecular Formula

C₁₉H₂₂O₃

SMILES

O1c2c(cc(C/C=C(/CCC=C(C)C)C)c(O)c2)ccc1=O

XLogP

5.348

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Schinkovitz A, Gibbons S, Stavri M, Cocksedge MJ, Bucar F.Ostruthin: an antimycobacterial coumarin from the Roots of Peucedanum ostruthium. Planta Med. 2003 Apr;69(4):369-7

Curator

Record - 4 of 4 [TOP]

Compound ID

2320

Compound Structure

Plant Source

Peucedanum ostruthium Koch Common Name:Masterwort

Source Family

Apiaceae (Umbelliferae)

Origin

China

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium smegmatis (ATCC 14468)

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Ostruthin

PubChem ID

5281420

Ethnomedicinal Information

Has folkloric reputation for the topical treatment of athletes foot

PubMed ID [Source Literature]

12709907

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Coumarin, Prenylated, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

298.157

Molecular Formula

C₁₉H₂₂O₃

SMILES

O1c2c(cc(C/C=C(/CCC=C(C)C)C)c(O)c2)ccc1=O

XLogP

5.348

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Schinkovitz A, Gibbons S, Stavri M, Cocksedge MJ, Bucar F.Ostruthin: an antimycobacterial coumarin from the Roots of Peucedanum ostruthium. Planta Med. 2003 Apr;69(4):369-7

Curator

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