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                  Page - 1 of 1                  Record - 1 of 5   [TOP]
Compound ID3341
Compound Structure
Plant SourcePhysalis angulata L.     Common Name:NR
Source FamilyAnacardiaceae
OriginSpanish Mediterranean Area
Plant Part UsedLeaf
ExtractMethanol
Target BacteriaMycobacterium phlei (CECT 3009)
Assay / Test DoneNR
Positive Control Used (conc.)Gentamicin (10 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml1 x 106 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationEscherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans
PubMed ID [Source Literature]3325696
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Reference(s)1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52

CuratorNajiya Beegum

                  Record - 2 of 5   [TOP]
Compound ID3373
Compound Structure
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Plant SourcePhysalis angulata L.     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedFresh leaf
Extract25 % NH4OH, 2 % HCl
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)0.1 ml of aliquot from each of the 10 - fold dilutions
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedPilocarpin
PubChem IDNR
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Alkaloid, Lactone, Imidazole
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight208.121
Molecular FormulaC11H16N2O2
SMILESO1C(=O)C(C(C1)Cc1n(cnc1)C)CC
XLogP1.307
PSA44.120
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 3 of 5   [TOP]
Compound ID3374
Compound Structure
DOWNLOAD:
Plant SourcePhysalis angulata L.     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedFresh leaf
Extract25 % NH4OH, 2 % HCl
Target BacteriaMycobacterium avium 733
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)0.1 ml of aliquot from each of the 10 - fold dilutions
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedPilocarpin
PubChem IDNR
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Alkaloid, Lactone, Imidazole
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight208.121
Molecular FormulaC11H16N2O2
SMILESO1C(=O)C(C(C1)Cc1n(cnc1)C)CC
XLogP1.307
PSA44.120
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 4 of 5   [TOP]
Compound ID3413
Compound Structure
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Plant SourcePhysalis angulata L.     Common Name:Camapu, Gooseberry, Hogweed, Balloon Cherry (English)
Source FamilySolanaceae
OriginBrazil
Plant Part UsedAerial
ExtractChloroform
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Rifampin (0.2 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml> 128 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedPhysalin B
PubChem ID   5488849
Ethnomedicinal InformationTumors, gastric troubles, diuretic, earache
PubMed ID [Source Literature]12203265
Extract PreparationAerial parts of P. angulata (83.56 g) were extracted with CHCl3. After solvent removal, the crude CHCl3 extract A (3.65 g) was fractionated over a silica gel column using Hex – AcOEt (7:3 - 3:7)
Chemical Classification [Active Compound]Alicyclic, Polycyclic, Steroid, Lactone, Ketone, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook liquid medium 7H9
Cytotoxicity Assay [AID]NR
Molecular Weight510.189
Molecular FormulaC28H30O9
SMILESO1C23C4C5(CC6OC(=O)C5COC1(C4=O)C1C(CCC2(O)C(=O)OC36C)C2(C(=CC1)CC=CC2=O)C)C
XLogP0.685
PSA125.430
H-bond Donor1
H-bond Acceptor9
No. of Rotatable Bond Count0
No. of Rings8
No. of N0
No. of O9
No. of S0
Reference(s)1) Januário AH, Filho ER, Pietro RC, Kashima S, Sato DN, França SC.Antimycobacterial physalins from Physalis angulata L. (Solanaceae).Phytother Res. 2002 Aug;16(5):445-8

2) Jain, S.K., 1991. Dictionary of Indian Folk Medicine and Ethnobotany. Deep Publications, New Delhi, India

CuratorWvarsha, rachanake

                  Record - 5 of 5   [TOP]
Compound ID3414
Compound Structure
DOWNLOAD:
Plant SourcePhysalis angulata L.     Common Name:Camapu, Gooseberry, Hogweed, Balloon Cherry (English)
Source FamilySolanaceae
OriginBrazil
Plant Part UsedAerial
ExtractChloroform
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Rifampin (0.2 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml32 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedPhysalin D
PubChem ID   431071
Ethnomedicinal InformationTumors, gastric troubles, diuretic, earache
PubMed ID [Source Literature]12203265
Extract PreparationAerial parts of P. angulata (83.56 g) were extracted with CHCl3. After solvent removal, the crude CHCl3 extract A (3.65 g) was fractionated over a silica gel column using Hex – AcOEt (7:3 3:7)
Chemical Classification [Active Compound]Alicyclic, Polycyclic, Steroid, Lactone, Ketone, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook liquid medium 7H9
Cytotoxicity Assay [AID]NR
Molecular Weight544.194
Molecular FormulaC28H32O11
SMILESO1C23C4C5(CC6OC(=O)C5COC1(C1C(C5(C(O)(C(O)C1)CC=CC5=O)C)CCC2(O)C(=O)OC36C)C4=O)C
XLogP-0.989
PSA165.890
H-bond Donor3
H-bond Acceptor11
No. of Rotatable Bond Count0
No. of Rings8
No. of N0
No. of O11
No. of S0
Reference(s)1) Januário AH, Filho ER, Pietro RC, Kashima S, Sato DN, França SC.Antimycobacterial physalins from Physalis angulata L. (Solanaceae).Phytother Res. 2002 Aug;16(5):445-8

2) Jain, S.K., 1991. Dictionary of Indian Folk Medicine and Ethnobotany. Deep Publications, New Delhi, India

CuratorWvarsha, rachanake


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