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                  Page - 1 of 1                  Record - 1 of 7   [TOP]
Compound ID2537
Compound Structure
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Plant SourceSalvia multicaulis Vahl     Common Name:
Source FamilyLamiaceae
OriginTurkey
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicro Broth Dilution Method
Positive Control Used (conc.)Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml5.6 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedMulticaulin
PubChem ID   467782
Ethnomedicinal InformationUsed in traditional medicine and have been associated with antibacterial, antituberculous and antiphlogistic activities
PubMed ID [Source Literature]9428161
Extract PreparationThe powdered roots of S. multicaulis (940 g) were extracted with acetone in a Soxhlet apparatus. The extract was evaporated in vacuo to give 23 g of a residue. The residue was fractionated by column chromatography on a silica gel column, eluted with petroleum ether, followed by a gradient of EtOAc up to 100% and then with EtOH. After TLC analysis, the combined fractions were purified by vacuum-liquid chromatography (VLC), eluting with petroleum ether and ethyl acetate
Chemical Classification [Active Compound]Aromatic, Tricyclic, Phenanthrene, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight278.167
Molecular FormulaC20H22O
SMILESO(c1c(C(C)C)cc2c(c3c(c(c(cc3)C)C)cc2)c1)C
XLogP8.150
PSA9.230
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O1
No. of S0
Reference(s)1) Ulubelen A, Topcu G, Johansson CB.Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity.J Nat Prod. 1997 Dec;60(12):1275-80

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                  Record - 2 of 7   [TOP]
Compound ID2538
Compound Structure
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Plant SourceSalvia multicaulis Vahl     Common Name:
Source FamilyLamiaceae
OriginTurkey
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml0.46 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified12 - demethylmulticauline
PubChem ID   467783
Ethnomedicinal InformationUsed in traditional medicine and have been associated with antibacterial, antituberculous and antiphlogistic activities
PubMed ID [Source Literature]9428161
Extract PreparationThe powdered roots of S. multicaulis (940 g) were extracted with acetone in a Soxhlet apparatus. The extract was evaporated in vacuo to give 23 g of a residue. The residue was fractionated by column chromatography on a silica gel column, eluted with petroleum ether, followed by a gradient of EtOAc up to 100% and then with EtOH. After TLC analysis, the combined fractions were purified by vacuum-liquid chromatography (VLC), eluting with petroleum ether and ethyl acetate
Chemical Classification [Active Compound]Aromatic, Tricyclic, Phenanthrene, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight264.151
Molecular FormulaC19H20O
SMILESOc1c(C(C)C)cc2c(c3c(c(c(cc3)C)C)cc2)c1
XLogP7.631
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O1
No. of S0
Reference(s)1) Ulubelen A, Topcu G, Johansson CB.Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity.J Nat Prod. 1997 Dec;60(12):1275-80

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                  Record - 3 of 7   [TOP]
Compound ID2539
Compound Structure
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Plant SourceSalvia multicaulis Vahl     Common Name:
Source FamilyLamiaceae
OriginTurkey
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedMultiorthoquinone
PubChem ID   467784
Ethnomedicinal InformationUsed in traditional medicine and have been associated with antibacterial, antituberculous and antiphlogistic activities
PubMed ID [Source Literature]9428161
Extract PreparationThe powdered roots of S. multicaulis (940 g) were extracted with acetone in a Soxhlet apparatus. The extract was evaporated in vacuo to give 23 g of a residue. The residue was fractionated by column chromatography on a silica gel column, eluted with petroleum ether, followed by a gradient of EtOAc up to 100% and then with EtOH. After TLC analysis, the combined fractions were purified by vacuum-liquid chromatography (VLC), eluting with petroleum ether and ethyl acetate
Chemical Classification [Active Compound]Aromatic, Phenanthrene, Quinone, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight308.141
Molecular FormulaC20H20O3
SMILESO(c1c(c(c2c(c3c(C=C(C(C)C)C(=O)C3=O)cc2)c1)C)C)C
XLogP4.636
PSA43.370
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O3
No. of S0
Reference(s)1) Ulubelen A, Topcu G, Johansson CB.Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity.J Nat Prod. 1997 Dec;60(12):1275-80

Curator

                  Record - 4 of 7   [TOP]
Compound ID2540
Compound Structure
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Plant SourceSalvia multicaulis Vahl     Common Name:
Source FamilyLamiaceae
OriginTurkey
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml1.2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified12 - Demethylmultiorthoquinone
PubChem ID   467785
Ethnomedicinal InformationUsed in traditional medicine and have been associated with antibacterial, antituberculous and antiphlogistic activities
PubMed ID [Source Literature]9428161
Extract PreparationThe powdered roots of S. multicaulis (940 g) were extracted with acetone in a Soxhlet apparatus. The extract was evaporated in vacuo to give 23 g of a residue. The residue was fractionated by column chromatography on a silica gel column, eluted with petroleum ether, followed by a gradient of EtOAc up to 100% and then with EtOH. After TLC analysis, the combined fractions were purified by vacuum-liquid chromatography (VLC), eluting with petroleum ether and ethyl acetate
Chemical Classification [Active Compound]Aromatic, Phenanthrene, Quinone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight294.126
Molecular FormulaC19H18O3
SMILESO=C1c2c3c(c(c(c(O)c3)C)C)ccc2C=C(C(C)C)C1=O
XLogP4.117
PSA54.370
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O3
No. of S0
Reference(s)1) Ulubelen A, Topcu G, Johansson CB.Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity.J Nat Prod. 1997 Dec;60(12):1275-80

Curator

                  Record - 5 of 7   [TOP]
Compound ID2541
Compound Structure
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Plant SourceSalvia multicaulis Vahl     Common Name:
Source FamilyLamiaceae
OriginTurkey
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml1.2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified12 - Methyl - 5 - dehydrohorminone
PubChem ID   467786
Ethnomedicinal InformationUsed in traditional medicine and have been associated with antibacterial, antituberculous and antiphlogistic activities
PubMed ID [Source Literature]9428161
Extract PreparationThe powdered roots of S. multicaulis (940 g) were extracted with acetone in a Soxhlet apparatus. The extract was evaporated in vacuo to give 23 g of a residue. The residue was fractionated by column chromatography on a silica gel column, eluted with petroleum ether, followed by a gradient of EtOAc up to 100% and then with EtOH. After TLC analysis, the combined fractions were purified by vacuum-liquid chromatography (VLC), eluting with petroleum ether and ethyl acetate
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Diterpene, Quinone, Ether, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight344.199
Molecular FormulaC21H28O4
SMILESO[C@@H]1C=C2[C@](CCCC2(C)C)(C2=C1C(=O)C(=C(OC)C2=O)C(C)C)C
XLogP3.577
PSA63.600
H-bond Donor1
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) Ulubelen A, Topcu G, Johansson CB.Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity.J Nat Prod. 1997 Dec;60(12):1275-80

Curator

                  Record - 6 of 7   [TOP]
Compound ID2542
Compound Structure
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Plant SourceSalvia multicaulis Vahl     Common Name:
Source FamilyLamiaceae
OriginTurkey
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml0.89 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified12 - Methyl - 5 - Dehydroacetylhorminone
PubChem ID   467787
Ethnomedicinal InformationUsed in traditional medicine and have been associated with antibacterial, antituberculous and antiphlogistic activities
PubMed ID [Source Literature]9428161
Extract PreparationThe powdered roots of S. multicaulis (940 g) were extracted with acetone in a Soxhlet apparatus. The extract was evaporated in vacuo to give 23 g of a residue. The residue was fractionated by column chromatography on a silica gel column, eluted with petroleum ether, followed by a gradient of EtOAc up to 100% and then with EtOH. After TLC analysis, the combined fractions were purified by vacuum-liquid chromatography (VLC), eluting with petroleum ether and ethyl acetate
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Diterpene, Quinone, O-Acetyl, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight386.209
Molecular FormulaC23H30O5
SMILESO([C@@H]1C=C2[C@](CCCC2(C)C)(C2=C1C(=O)C(=C(OC)C2=O)C(C)C)C)C(=O)C
XLogP4.317
PSA69.670
H-bond Donor0
H-bond Acceptor5
No. of Rotatable Bond Count4
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Ulubelen A, Topcu G, Johansson CB.Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity.J Nat Prod. 1997 Dec;60(12):1275-80

Curator

                  Record - 7 of 7   [TOP]
Compound ID2543
Compound Structure
DOWNLOAD:
Plant SourceSalvia multicaulis Vahl     Common Name:
Source FamilyLamiaceae
OriginTurkey
Plant Part UsedRoot
ExtractAcetone
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml7.3 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedSalvipimarone
PubChem ID   467788
Ethnomedicinal InformationUsed in traditional medicine and have been associated with antibacterial, antituberculous and antiphlogistic activities
PubMed ID [Source Literature]9428161
Extract PreparationThe powdered roots of S. multicaulis (940 g) were extracted with acetone in a Soxhlet apparatus. The extract was evaporated in vacuo to give 23 g of a residue. The residue was fractionated by column chromatography on a silica gel column, eluted with petroleum ether, followed by a gradient of EtOAc up to 100% and then with EtOH. After TLC analysis, the combined fractions were purified by vacuum-liquid chromatography (VLC), eluting with petroleum ether and ethyl acetate
Chemical Classification [Active Compound]Alicyclic, Tricyclic, Terpene, Diterpene, Ketone, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight332.199
Molecular FormulaC20H28O4
SMILESO[C@]12[C@@]3(C(C(C(=O)CC3)(C)C)C[C@@H](O)C1=C[C@@](CC2=O)(C)C=C)C
XLogP1.850
PSA74.600
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) Ulubelen A, Topcu G, Johansson CB.Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity.J Nat Prod. 1997 Dec;60(12):1275-80

Curator


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