BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 9 [TOP]

Compound ID	2549
Compound Structure
Plant Source	Sanguinaria canadensis Linn. Common Name:Bloodroot
Source Family	Papaveraceae
Origin	North America
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	62.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 2 of 9 [TOP]

Compound ID	2550
Compound Structure
Plant Source	Sanguinaria canadensis Linn. Common Name:Bloodroot
Source Family	Papaveraceae
Origin	North America
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 3 of 9 [TOP]

Compound ID

2551

Compound Structure

Plant Source

Sanguinaria canadensis Linn. Common Name:Bloodroot

Source Family

Papaveraceae

Origin

North America

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium aurum

Assay / Test Done

Broth Microdilution Method (BMM)

Positive Control Used (conc.)

Streptomycin (1.14 ± 0.02 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

9.61 ± 4.52 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sanguinarine

PubChem ID

5154

Ethnomedicinal Information

Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

332.092

Molecular Formula

C₂₀H₁₄NO₄

SMILES

O1c2c3c(c4c([n+](c3)C)c3c(cc4)cc4OCOc4c3)ccc2OC1

XLogP

3.297

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67

Curator

Record - 4 of 9 [TOP]

Compound ID

2552

Compound Structure

Plant Source

Sanguinaria canadensis Linn. Common Name:Bloodroot

Source Family

Papaveraceae

Origin

North America

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium smegmatis

Assay / Test Done

Broth Microdilution Method (BMM)

Positive Control Used (conc.)

Streptomycin (0.17 ± 0.04 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

41.18 ± 16.85 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sanguinarine

PubChem ID

5154

Ethnomedicinal Information

Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

332.092

Molecular Formula

C₂₀H₁₄NO₄

SMILES

O1c2c3c(c4c([n+](c3)C)c3c(cc4)cc4OCOc4c3)ccc2OC1

XLogP

3.297

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 5 of 9 [TOP]

Compound ID

2553

Compound Structure

Plant Source

Sanguinaria canadensis Linn. Common Name:Bloodroot

Source Family

Papaveraceae

Origin

North America

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium bovis (BCG - Bacillus Calmette Guerin)

Assay / Test Done

Broth Microdilution Method (BMM)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

24.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sanguinarine

PubChem ID

5154

Ethnomedicinal Information

Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

332.092

Molecular Formula

C₂₀H₁₄NO₄

SMILES

O1c2c3c(c4c([n+](c3)C)c3c(cc4)cc4OCOc4c3)ccc2OC1

XLogP

3.297

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 6 of 9 [TOP]

Compound ID

2554

Compound Structure

Plant Source

Sanguinaria canadensis Linn. Common Name:Bloodroot

Source Family

Papaveraceae

Origin

North America

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium aurum

Assay / Test Done

Broth Microdilution Method (BMM)

Positive Control Used (conc.)

Streptomycin (1.14 ± 0.02 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

7.30 ± 1.91 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Chelerythrine

PubChem ID

2703

Ethnomedicinal Information

Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Quinoline,Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

348.124

Molecular Formula

C₂₁H₁₈NO₄

SMILES

O1c2cc3c4[n+](cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C

XLogP

3.370

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 7 of 9 [TOP]

Compound ID

2555

Compound Structure

Plant Source

Sanguinaria canadensis Linn. Common Name:Bloodroot

Source Family

Papaveraceae

Origin

North America

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium smegmatis

Assay / Test Done

Broth Microdilution Method (BMM)

Positive Control Used (conc.)

Streptomycin (0.17 ± 0.04 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

29.00 ± 17.60 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Chelerythrine

PubChem ID

2703

Ethnomedicinal Information

Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Quinoline,Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

348.124

Molecular Formula

C₂₁H₁₈NO₄

SMILES

O1c2cc3c4[n+](cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C

XLogP

3.370

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 8 of 9 [TOP]

Compound ID

2556

Compound Structure

Plant Source

Sanguinaria canadensis Linn. Common Name:Bloodroot

Source Family

Papaveraceae

Origin

North America

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium bovis (BCG - Bacillus Calmette Guerin)

Assay / Test Done

Broth Microdilution Method (BMM)

Positive Control Used (conc.)

Streptomycin (0.17 ± 0.04 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

14.3 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Chelerythrine

PubChem ID

2703

Ethnomedicinal Information

Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Quinoline,Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

348.124

Molecular Formula

C₂₁H₁₈NO₄

SMILES

O1c2cc3c4[n+](cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C

XLogP

3.370

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 9 of 9 [TOP]

Compound ID	2557
Compound Structure
Plant Source	Sanguinaria canadensis Linn. Common Name:Bloodroot
Source Family	Papaveraceae
Origin	North America
Plant Part Used	Root
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gottshall RY, Lucas EH, Lickfeldt A, Roberts JM. 1949. The occurrence of antibacterial substances active against Mycobacterium tuberculosis in seed plants. J Clin Invest 28: 920±92
Curator

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