BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 5 [TOP]

Compound ID	2703
Compound Structure
Plant Source	Terminalia avicennioides Guill. & Perr. Common Name:
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Mistletoes, root bark, fruit
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	78 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, hemoptysis, tuberculosis, sore throat, diarrhea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) Mann A, Gbate M, Nda-Umar A. Medicinal and Economic Plants of Nupeland. Bida, Niger State, Nigeria: Jube-Evans Books and Publications; 2003. p. 276
Curator

Record - 2 of 5 [TOP]

Compound ID	2704
Compound Structure
Plant Source	Terminalia avicennioides Guill. & Perr. Common Name:
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Mistletoes, root bark, fruit
Extract	Hexane
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, hemoptysis, tuberculosis, sore throat, diarrhea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) Mann A, Gbate M, Nda-Umar A. Medicinal and Economic Plants of Nupeland. Bida, Niger State, Nigeria: Jube-Evans Books and Publications; 2003. p. 276
Curator

Record - 3 of 5 [TOP]

Compound ID	2705
Compound Structure
Plant Source	Terminalia avicennioides Guill. & Perr. Common Name:
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Mistletoes, root bark, fruit
Extract	Ethyl acetate soluble
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	625 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, hemoptysis, tuberculosis, sore throat, diarrhea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) Mann A, Gbate M, Nda-Umar A. Medicinal and Economic Plants of Nupeland. Bida, Niger State, Nigeria: Jube-Evans Books and Publications; 2003. p. 276
Curator

Record - 4 of 5 [TOP]

Compound ID	2706
Compound Structure
Plant Source	Terminalia avicennioides Guill. & Perr. Common Name:
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Mistletoes, root bark, fruit
Extract	Methanol
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, hemoptysis, tuberculosis, sore throat, diarrhea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) Mann A, Gbate M, Nda-Umar A. Medicinal and Economic Plants of Nupeland. Bida, Niger State, Nigeria: Jube-Evans Books and Publications; 2003. p. 276
Curator

Record - 5 of 5 [TOP]

Compound ID

2707

Compound Structure

Plant Source

Terminalia avicennioides Guill. & Perr. Common Name:

Source Family

Combretaceae

Origin

Nigeria

Plant Part Used

Stem bark

Extract

Target Bacteria

Mycobacterium fortuitum

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Imberbic acid

PubChem ID

Ethnomedicinal Information

Asthma, cough, hemoptysis, tuberculosis, sore throat, diarrhea

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Pentacyclic, Triterpene, Hydroxy, Acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

472.355

Molecular Formula

C₃₀H₄₈O₄

SMILES

C1([C@H]2[C@@]([C@@H]3[C@@](CC2)([C@]2(C(=CC3)[C@H]3[C@@](CC2)(CC[C@](C3)(C(=O)O)C)C)C)C)([C@H](C[C@@H]1O)O)C)(C)C

XLogP

7.389

PSA

77.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21

2) Mann A, Gbate M, Nda-Umar A. Medicinal and Economic Plants of Nupeland. Bida, Niger State, Nigeria: Jube-Evans Books and Publications; 2003. p. 276

Curator

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