| Compound ID | 2800 |
| Compound Structure | |
| Plant Source | Warbugia salutaris (Bertol. f.) Chiov Common Name:Pepper - Bark Tree |
| Source Family | Canellaceae |
| Origin | Africa |
| Plant Part Used | Leaf |
| Extract | Acetone |
| Target Bacteria | Mycobacterium tuberculosis H37Ra |
| Assay / Test Done | Tetrazolium Microplate Assay (TEMA) |
| Positive Control Used (conc.) | Rifampin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (2.00 µg/ml), Streptomycin (0.50 µg/ml) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | 25 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Colds, sinuses, influenza and other chest complaints, antiparasitic powder applied to sores, fever, coughs, respiratory ailments |
| PubMed ID [Source Literature] | 20447452 |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
2) http://www.plantzAfrica.com/plantwxyz/warburg.htm
|
| Curator | |
| Compound ID | 2801 |
| Compound Structure | |
| Plant Source | Warbugia salutaris (Bertol. f.) Chiov Common Name:Pepper - Bark Tree |
| Source Family | Canellaceae |
| Origin | Africa |
| Plant Part Used | Leaf |
| Extract | Acetone |
| Target Bacteria | Mycobacterium tuberculosis 2 (Clinical isolates resistant to Streptomycin, Rifampin, Ethambutol, Isoniazid) |
| Assay / Test Done | Tetrazolium Microplate Assay (TEMA) |
| Positive Control Used (conc.) | Rifampin (100 µg/ml), Isoniazid (4.6 µg/ml), Ethambutol (12 µg/ml), Streptomycin (120 µg/ml) |
| Inhibition [%] | |
| Activity [MIC] µg/ml | 25 µg/ml |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Colds, sinuses, influenza and other chest complaints, antiparasitic powder applied to sores, fever, respiratory ailments |
| PubMed ID [Source Literature] | 20447452 |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
2) http://www.plantzAfrica.com/plantwxyz/warburg.htm
|
| Curator | |
| Compound ID | 2802 |
| Compound Structure | |
| Plant Source | Warbugia salutaris (Bertol. f.) Chiov Common Name:Pepper - Bark Tree |
| Source Family | Canellaceae |
| Origin | Africa |
| Plant Part Used | Bark or root bark |
| Extract | Dichloromethane bark extract |
| Target Bacteria | Mycobacterium tuberculosis, Mycobacterium bovis BCG |
| Assay / Test Done | |
| Positive Control Used (conc.) | |
| Inhibition [%] | |
| Activity [MIC] µg/ml | |
| Activity (In terms of dilution) | |
| Activity (Zone of inhibition in mm) | |
| Active Compound Identified | |
| PubChem ID | NR |
| Ethnomedicinal Information | Colds, sinuses, influenza and other chest complaints, antiparasitic powder applied to sores, fever, respiratory ailments |
| PubMed ID [Source Literature] | |
| Extract Preparation | N/A |
| Chemical Classification [Active Compound] | N/A |
| Media / Broth Used [Antimicrobial Assay/Test] | N/A |
| Cytotoxicity Assay [AID] | N/A |
| Reference(s) | 1) Clarkson C, Madikane EV, Hansen SH, Smith PJ, Jaroszewski JW.HPLC-SPE-NMR characterization of sesquiterpenes in an antimycobacterial fraction from Warburgia salutaris.Planta Med. 2007 Jun;73(6):578-84
2) http://www.plantzAfrica.com/plantwxyz/warburg.htm
|
| Curator | |
