BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 9 [TOP]

Compound ID	2831
Compound Structure
Plant Source	Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)
Source Family	Zingiberaceae
Origin	India, Malaysia
Plant Part Used	Rhizome
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done	Radiorespirometric Bioassay
Positive Control Used (conc.)
Inhibition [%]	85 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) R.D. Hiserodt,S.G. Franzblau and R.T. Rosen.Isolation of 6-, 8-, and 10-Gingerol from Ginger Rhizome by HPLC and Preliminary Evaluation of Inhibition of Mycobacterium avium and Mycobacterium tuberculosis.J. Agric. Food Chem., 1998, 46 (7), pp 2504–2508 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India 3) Jain, S.K., Tarafder, C.R., 1970. Medicinal plant lore of the Santals. A revival of P.O. Boddings, work. Economic Botany 24, 241–278
Curator

Record - 2 of 9 [TOP]

Compound ID

2833

Compound Structure

Plant Source

Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)

Source Family

Zingiberaceae

Origin

India, Malaysia

Plant Part Used

Rhizome

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

10 - Gingerol

PubChem ID

168115

Ethnomedicinal Information

Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkyl, Ketone, Ether, Phenol, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

350.246

Molecular Formula

C₂₁H₃₄O₄

SMILES

O[C@@H](CCCCCCCCC)CC(=O)CCc1cc(OC)c(O)cc1

XLogP

5.163

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) R.D. Hiserodt,S.G. Franzblau and R.T. Rosen.Isolation of 6-, 8-, and 10-Gingerol from Ginger Rhizome by HPLC and Preliminary Evaluation of Inhibition of Mycobacterium avium and Mycobacterium tuberculosis.J. Agric. Food Chem., 1998, 46 (7), pp 2504–2508

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

3) Jain, S.K., Tarafder, C.R., 1970. Medicinal plant lore of the Santals. A revival of P.O. Boddings, work. Economic Botany 24, 241–278.

Curator

Record - 3 of 9 [TOP]

Compound ID

2834

Compound Structure

Plant Source

Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)

Source Family

Zingiberaceae

Origin

India, Malaysia

Plant Part Used

Rhizome

Extract

Dichloromethane

Target Bacteria

Mycobacterium avium

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

10 - Gingerol

PubChem ID

168115

Ethnomedicinal Information

Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkyl, Ketone, Ether, Phenol, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

350.246

Molecular Formula

C₂₁H₃₄O₄

SMILES

O[C@@H](CCCCCCCCC)CC(=O)CCc1cc(OC)c(O)cc1

XLogP

5.163

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 4 of 9 [TOP]

Compound ID

2835

Compound Structure

Plant Source

Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)

Source Family

Zingiberaceae

Origin

India, Malaysia

Plant Part Used

Rhizome

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

8 - Gingerol

PubChem ID

5275725

Ethnomedicinal Information

Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkyl, Ketone, Ether, Alcohol, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

322.214

Molecular Formula

C₁₉H₃₀O₄

SMILES

OC(CCCCCCC)CC(=O)CCc1cc(OC)c(O)cc1

XLogP

4.025

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 5 of 9 [TOP]

Compound ID

2836

Compound Structure

Plant Source

Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)

Source Family

Zingiberaceae

Origin

India, Malaysia

Plant Part Used

Rhizome

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

> 100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

6 - Gingerol

PubChem ID

3473

Ethnomedicinal Information

Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Butenolide, Lactone, Alkene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

294.183

Molecular Formula

C₁₇H₂₆O₄

SMILES

OC(CCCCC)CC(=O)CCc1cc(OC)c(O)cc1

XLogP

2.887

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 6 of 9 [TOP]

Compound ID	2837
Compound Structure
Plant Source	Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)
Source Family	Zingiberaceae
Origin	India, Malaysia
Plant Part Used	Rhizome
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1600 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis
PubMed ID [Source Literature]	21094237
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mohamad S, Zin NM, Wahab HA, Ibrahim P, Sulaiman SF, Zahariluddin AS, Noor SS.Antituberculosis potential of some ethnobotanically selected Malaysian plants.J Ethnopharmacol. 2011 Feb 16;133(3):1021-6
Curator

Record - 7 of 9 [TOP]

Compound ID	2838
Compound Structure
Plant Source	Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)
Source Family	Zingiberaceae
Origin	India, Malaysia
Plant Part Used	Rhizome
Extract	Methylene chloride
Target Bacteria
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)
Inhibition [%]	85 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis
PubMed ID [Source Literature]	21094237
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mohamad S, Zin NM, Wahab HA, Ibrahim P, Sulaiman SF, Zahariluddin AS, Noor SS.Antituberculosis potential of some ethnobotanically selected Malaysian plants.J Ethnopharmacol. 2011 Feb 16;133(3):1021-6
Curator

Record - 8 of 9 [TOP]

Compound ID

3983

Compound Structure

Plant Source

Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)

Source Family

Zingiberaceae

Origin

India, Malaysia

Plant Part Used

Rhizome

Extract

Dichloromethane

Target Bacteria

Mycobacterium avium

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

> 100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

6 - Gingerol

PubChem ID

3473

Ethnomedicinal Information

Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis

PubMed ID [Source Literature]

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Butenolide, Lactone, Alkene

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

294.183

Molecular Formula

C₁₇H₂₆O₄

SMILES

OC(CCCCC)CC(=O)CCc1cc(OC)c(O)cc1

XLogP

2.887

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 9 of 9 [TOP]

Compound ID

3982

Compound Structure

Plant Source

Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)

Source Family

Zingiberaceae

Origin

India, Malaysia

Plant Part Used

Rhizome

Extract

Dichloromethane

Target Bacteria

Mycobacterium avium

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

8 - Gingerol

PubChem ID

5275725

Ethnomedicinal Information

Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis

PubMed ID [Source Literature]

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkyl, Ketone, Ether, Alcohol, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

322.214

Molecular Formula

C₁₉H₃₀O₄

SMILES

OC(CCCCCCC)CC(=O)CCc1cc(OC)c(O)cc1

XLogP

4.025

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

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