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                  Page - 1 of 1                  Record - 1 of 4   [TOP]
Compound ID3849
Compound Structure
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Plant SourceApple, Tea, Cinnamon, Cassia and other plants (not reported specifically)     Common Name:NR
Source FamilyNR
OriginNR
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium avium subsp. paratuberculosis (bovine isolate [NCTC 8578])
Assay / Test DoneMacro - broth susceptibility testing using Bactec 460 system
Positive Control Used (conc.)Rifampin (< 0.6 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml72.2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCarvacrol
PubChem ID   10364
Ethnomedicinal InformationNR
PubMed ID [Source Literature]18676709
Extract PreparationNR
Chemical Classification [Active Compound]Aromatic, Terpene, Monoterpene, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth
Cytotoxicity Assay [AID]NR
Molecular Weight150.104
Molecular FormulaC10H14O
SMILESOc1cc(C(C)C)ccc1C
XLogP3.556
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count1
No. of Rings1
No. of N0
No. of O1
No. of S0
Reference(s)1) Wong SY, Grant IR, Friedman M, Elliott CT, Situ C.Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis.Appl Environ Microbiol. 2008 Oct;74(19):5986-90. Epub 2008 Aug 1

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 2 of 4   [TOP]
Compound ID3850
Compound Structure
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Plant SourceApple, Tea, Cinnamon, Cassia and other plants (not reported specifically)     Common Name:NR
Source FamilyNR
OriginNR
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium avium subsp. paratuberculosis (human isolate [ATCC 43015])
Assay / Test DoneMacro - broth susceptibility testing using Bactec 460 system
Positive Control Used (conc.)Rifampin (< 0.6 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml72.2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCarvacrol
PubChem ID   10364
Ethnomedicinal InformationNR
PubMed ID [Source Literature]18676709
Extract PreparationNR
Chemical Classification [Active Compound]Aromatic, Terpene, Monoterpene, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth
Cytotoxicity Assay [AID]NR
Molecular Weight150.104
Molecular FormulaC10H14O
SMILESOc1cc(C(C)C)ccc1C
XLogP3.556
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count1
No. of Rings1
No. of N0
No. of O1
No. of S0
Reference(s)1) Wong SY, Grant IR, Friedman M, Elliott CT, Situ C.Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis.Appl Environ Microbiol. 2008 Oct;74(19):5986-90. Epub 2008 Aug 1

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 3 of 4   [TOP]
Compound ID3851
Compound Structure
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Plant SourceApple, Tea, Cinnamon, Cassia and other plants (not reported specifically)     Common Name:NR
Source FamilyNR
OriginNR
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium avium subsp. paratuberculosis (raw - milk isolate [806R])
Assay / Test DoneMacro - broth susceptibility testing using Bactec 460 system
Positive Control Used (conc.)Rifampin (< 0.6 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml72.2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCarvacrol
PubChem ID   10364
Ethnomedicinal InformationNR
PubMed ID [Source Literature]18676709
Extract PreparationNR
Chemical Classification [Active Compound]Aromatic, Terpene, Monoterpene, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H9 broth
Cytotoxicity Assay [AID]NR
Molecular Weight150.104
Molecular FormulaC10H14O
SMILESOc1cc(C(C)C)ccc1C
XLogP3.556
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count1
No. of Rings1
No. of N0
No. of O1
No. of S0
Reference(s)1) Wong SY, Grant IR, Friedman M, Elliott CT, Situ C.Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis.Appl Environ Microbiol. 2008 Oct;74(19):5986-90. Epub 2008 Aug 1

CuratorKeyaMukherjee, Farzana Shamsudeen

                  Record - 4 of 4   [TOP]
Compound ID3899
Compound Structure
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Plant SourceLippia origanoides     Common Name:NR
Source FamilyVerbenaceae
OriginColombia
Plant Part UsedLeaf, stem
ExtractEssential oil (3 .1 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml125 ± 0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCarvacrol (1.7 %)
PubChem ID   10364
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19753839
Extract PreparationThe essential oils were extracted from a 300 g sample of plant leaves and stems by microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven. Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]Aromatic, Terpene, Monoterpene, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Lowestein - Jensenn medium, Middlebrook 7H9 medium [The later was supplemented with 10 % OADC (Oleic Acid - Albumin - Dextrose - Catalase) and 0.001 % Tween 80]
Cytotoxicity Assay [AID]NR
Molecular Weight150.104
Molecular FormulaC10H14O
SMILESOc1cc(C(C)C)ccc1C
XLogP3.556
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count1
No. of Rings1
No. of N0
No. of O1
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

CuratorKeyaMukherjee, Farzana Shamsudeen


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